Decrypting the Potential of Lipidic Vesicular System for Delivery Enhancement of Tranexamic Acid in Melasma Hyperpigmentation Treatment [0.03%]
脂质囊泡递送系统增强氨甲环酸治疗黄褐斑色素沉着的潜力研究
Xin Lu Soo,Kang Nien How,Zee Wei Lai
Xin Lu Soo
Melasma is a prevalent pigmentary disorder characterized by irregular brown patches on sun-exposed face and neck regions, driven by increased vascular proliferation and dysregulated melanogenesis. Although benign, untreated melasma signific...
The Role of Autophagy in Long-term Effects of Spinal Cord Injury: Does Exosome Change the Autophagy Process and Vice Versa? [0.03%]
自噬在脊髓损伤远期效应中的作用：外泌体和自噬会相互影响过程吗？
Naeimeh Akbari-Gharalari,Abbas Ebrahimi-Kalan,Zeinab Aliyari-Serej et al.
Naeimeh Akbari-Gharalari et al.
This review explores the synergistic effects of exosomes and autophagy in mitigating spinal cord injury (SCI) while elucidating the underlying molecular mechanisms. We evaluate current literature on the roles of exosomes and autophagy in SC...
Serine/Arginine Protein Kinase Inhibitors Potentiate Melanoma Cell Death and Metastatic Inhibition Through Apoptotic Protein Triggering and Vimentin Dysregulation [0.03%]
丝氨酸/精氨酸蛋白激酶抑制剂通过凋亡蛋白触发和波形蛋白失调增强黑色素瘤细胞死亡和转移抑制作用
Atit Silsirivanit,Chaturong Inpad,Jesadagorn Siriwath et al.
Atit Silsirivanit et al.
Purpose: Melanoma arises from the malignant transformation of melanocytes, a serious health problem in high UV-exposure countries. Ineffective treatments and metastasis have led to poor prognosis and high mortality among ...
A Newly Developed TGF-Β-Responsive CAR T Cell for Enhanced Proliferation and Cytokine Secretion [0.03%]
一种新型TGF-β响应型CAR-T细胞促进增殖和细胞因子分泌
Shafieeh Mansoori,Mohammad Ali Shokrgozar,Monireh Gholizadeh et al.
Shafieeh Mansoori et al.
Purpose: Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising cancer treatment. Nevertheless, the tumor microenvironment (TME) of solid tumors provides substantial challenges to CAR T cell efficacy. T...
The Use of Rare Earth Glass Microspheres and Graphene Quantum Dots Glass Microspheres for Biological Applications: Cancer Insight [0.03%]
基于稀土玻璃微球和石墨烯量子点玻璃微球的生物应用及癌症诊疗研究进展
Jéssica Ingrid Faria De Souza,Natália Cristina Gomes-da-Silva,Filipe Ferreira Ascenção et al.
Jéssica Ingrid Faria De Souza et al.
Purpose: This study explores the use of glass microspheres doped with rare earth elements, specifically samarium (Sm) and neodymium (Nd), and graphene quantum dots (GQDs) in biological applications, particularly cancer th...
Milad Asadi,Sanam Sadeghi-Mohammadi,Najibeh Shekari et al.
Milad Asadi et al.
Circular RNAs (circRNAs) are a novel class of non-coding RNAs primarily generated through a back-splicing processes. These molecules exhibit extensive expression across various tissues, indicating their significant role in numerous biologic...
Platelet-Rich Plasma in Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis [0.03%]
富血小板血浆在间质性膀胱炎/膀胱疼痛综合征中的应用：系统评价和 meta 分析
Sakineh Hajebrahimi,Fateme Tahmasbi,Elham Jahantabi et al.
Sakineh Hajebrahimi et al.
Purpose: This systematic review aims to critically evaluate the safety and efficacy of PRP therapy in managing interstitial cystitis/bladder pain syndrome (IC/BPS). ...
Localized Semaglutide Injection for Hyperinsulinemia-Induced Lymphatic Dysfunction: A Narrative Review Proposing a Promising Metabolic Perspective for Lymphedema Therapy [0.03%]
针对高胰岛素血症诱导的淋巴功能障碍的司美格鲁肽注射治疗：一篇关于淋巴水肿治疗代谢学视角的叙述性评论文章
Maher Monir Akl,Amr Ahmed
Maher Monir Akl
Lymphedema, traditionally viewed as a mechanical consequence of lymphatic obstruction, is increasingly recognized as a complex disorder rooted in metabolic dysfunction, particularly insulin resistance and chronic hyperinsulinemia. This para...
Genosomes: An Introspection into Transfection, Future Perspectives and Applications [0.03%]
基因体：转染的自我审视、未来展望及应用
Abhirami Subramony,Divyatha Raj,Fiza Fairooz et al.
Abhirami Subramony et al.
The advent of advanced gene delivery platforms has transformed the precision targeting of therapeutic nucleic acids, such as miRNA, siRNA, and pDNA, for the treatment of genetic and acquired diseases, including cystic fibrosis, malignancies...