Galangin's Therapeutic Potential in Retinoblastoma: Inducing Apoptosis and Modulating RB Protein and Some MicroRNAs [0.03%]
染料木素治疗视网膜母细胞瘤的潜力：诱导凋亡并调节RB蛋白和一些microRNA
Maryam Zamani Sani,Mohammad Mirzaei,Ali Mota et al.
Maryam Zamani Sani et al.
Introduction: Retinoblastoma is a type of cancer that develops in the retina, mainly affecting infants and young children under five years old. Research indicates that microRNAs (miRNAs) can either promote or suppress can...
Dual Modulation of Senescence and Immune Checkpoints by Metformin and Dapagliflozin Attenuates Liver Fibrosis in a Thioacetamide-Induced Rat Model [0.03%]
二甲双胍和达格列净通过调节免疫检查点及衰老微环境治疗肝纤维化研究
Asmaa Ramadan,Ahmed A Shaaban,Mohammad E Rabeh et al.
Asmaa Ramadan et al.
Introduction: Liver fibrosis, characterized by excessive extracellular matrix accumulation, reflects a maladaptive repair response to persistent hepatic injury. Recent studies implicate cellular senescence and immune chec...
Histone Deacetylase Inhibitor Combined with Rosiglitazone Improves Cognitive Function Via Microglial Polarization and Increased Mature/Pro-BDNF in Alzheimer's Disease [0.03%]
组蛋白去乙酰化酶抑制剂联合罗格列酮通过小胶质细胞极化和增加成熟的/前体BDNF改善阿尔茨海默病认知功能
Melina Rafiey,Rahim Nosrati,Arash Pourgholaminejad et al.
Melina Rafiey et al.
Introduction: Alzheimer's disease (AD) is characterized by diminished brain metabolism, cognitive impairments, neural loss, astrogliosis, and microgliosis. We hypothesized that co-administration of a peroxisome proliferat...
Apigenin as a Multi-Targeted Agent in Gastrointestinal Cancers: A Systems Pharmacology Approach [0.03%]
基于系统药理学的青蒿素在胃肠肿瘤中作为多靶向药物的研究
Duaa Kamel Al-Moussawi,Aseel Kamil Mohammed Al-Mosawi,Awatif Mokar Dayesh et al.
Duaa Kamel Al-Moussawi et al.
Introduction: Apigenin, a dietary flavonoid found in various medicinal plants, has demonstrated notable anticancer effects. However, its multi-targeted molecular mechanisms in gastrointestinal (GI) cancers remain poorly u...
Optimizing Expression of a Llama-Based Anti-PSMA Nanobody in Escherichia Coli and Its Application in Immunohistochemistry of Prostate Cancer Tissues [0.03%]
基于羊驼的抗PSMA纳米抗体在大肠杆菌中的表达优化及其在前列腺癌组织免疫组化中的应用
Seyedeh Sheila Seyed-Motahari,Shahriyar Abdoli,Mohammad Ali Shokrgozar et al.
Seyedeh Sheila Seyed-Motahari et al.
Purpose: Nanobodies possess unique properties that make them promising as tumor targeting agents. Prostate-specific membrane antigen (PSMA), overexpressed in prostate cancer, can be an excellent target for prostate cancer...
Hidden Hazards: Blood Lead and Cadmium Levels Associated with Biochemical and Hematological Markers [0.03%]
隐忧：血液中的铅和镉水平与生化及血液学标志物的关系
Mina Islambulchilar,Ali Shayanfar,Meisam Bagheri et al.
Mina Islambulchilar et al.
Introduction: Workers occupationally exposed to fuel vapors are at risk of contamination by heavy metals such as lead and cadmium. This study aimed to quantify blood levels of lead and cadmium and evaluate associated bioc...
The Effect of Glycosylation on Biodistribution and Cytotoxicity of 99mTc-Radiolabeled Luteolin [0.03%]
糖基化对99mTc放射性标记白杨素的生物分布及细胞毒性的效果研究
Mostafa Pirali Hamedani,Mohammad Seyedhamzeh,Mohammad H Ghahremani et al.
Mostafa Pirali Hamedani et al.
Introduction: Luteolin (Lu) and its glycosylated derivative, luteolin-7-O-glucoside (LuG), are the main bioactive flavonoids reported in the Scutellaria genus. Still, in vivo biodistribution and cytotoxic effects on cance...
GAS2 Co-Expression Networks in Breast Cancer: Identification of Potential Biomarkers and Therapeutic Targets [0.03%]
乳腺癌中GAS2共表达网络：潜在生物标志物和治疗靶点的鉴定
Samin Rahimi,Mehdi Haghi,Dariush Najarzadeh et al.
Samin Rahimi et al.
Introduction: Breast Cancer (BCa) remains the leading cause of cancer-related mortality among women, underscoring the need for developing more effective novel biomarkers. This study investigated the role of Growth Arrest-...
The RNA-Binding Proteins Promote Resistance of Microglial Cells to Hypoxia [0.03%]
RNA结合蛋白促进小胶质细胞耐低氧性
Mohammad Khosravi,Zohreh Ghotbeddin,Sorour Chinipardaz
Mohammad Khosravi
Introduction: Microglial cells play a crucial role in responding to brain hypoxia. This study aimed to evaluate the effect of RNA-binding proteins (RBPs) on the resistance of microglial cells to hypoxia. ...
The Effects of Coenzyme Q10 Supplementation on the Contrast Sensitivity Score, Biomarkers of Oxidative Stress, Inflammation, and β-Secretase Activity in the Blood and the Correlation Among these Factors in Diabetic Retinopathy Patients; Clinical Trial [0.03%]
辅酶Q10补充对糖尿病视网膜病变患者对比敏感度评分、氧化应激生物标志物、炎症和β-分泌酶活性的影响及其相关性：临床试验研究
Mohammad Hossein Sharif,Fatemeh Javadian Sarraf,Ehsan Sharifipour et al.
Mohammad Hossein Sharif et al.
Introduction: Diabetic retinopathy (DR), the most common complication of diabetes and is recognized as the leading cause of visual impairment. Coenzyme Q10 (CoQ10) is a nonenzymatic antioxidant that restores other antioxi...