Nogapendekin alfa Inbakicept-pmln (Anktiva) with BCG: A Promising Arsenal in BCG-Unresponsive Non-Muscle-Invasive Bladder Cancer Intervention [0.03%]
无Gap激活的Inbixacept-pmln（anktlva）与BCG联合用药：治疗对BCG无反应的非肌肉浸润性膀胱癌的一种有前景的方法
ArunSundar MohanaSundaram,Velmurugan Raja,Yeshwanth Kamalakannan et al.
ArunSundar MohanaSundaram et al.
An Optimized Method for Single Cell Cloning of Human CAR-T Cells Based on FBS-Coated Plates [0.03%]
基于FBS包被培养板的单细胞克隆优化方法在人源CAR-T细胞中的应用
Mahdie Jafari,Shahriyar Abdoli,Masoud Moghaddam Pour et al.
Mahdie Jafari et al.
Purpose: T cell-based immunotherapy, especially chimeric antigen receptor (CAR)-T cells, has emerged as an appropriate approach for treating hematologic malignancies and is currently under investigation in clinical trials...
Exosome-Like Nanoparticles from Indonesian Red and Emprit Ginger Varieties Suppress LPS-Induced IL-6 Production in RAW 264.7 Macrophages [0.03%]
印度尼西亚红姜和Emprit姜品种的类外泌体纳米颗粒可抑制LPS诱导的RAW 264.7巨噬细胞中IL-6产生
Daisy Ramadhani Muhammad,Natasya Emmanuela,Iriawati Iriawati et al.
Daisy Ramadhani Muhammad et al.
Purpose: Studies have shown the potential of exosomes as therapeutic agents with anti-inflammatory properties. However, the clinical application of mammalian-derived exosomes is hindered by mass production challenges and ...
Preparation and Anti-cancer Evaluation of Methotrexate-loaded Inositol-6 Phosphate Cross-linked Chitosan Nanoparticles on Breast Cancer [0.03%]
用于乳腺癌治疗的甲氨蝶呤载磷酸肌醇六元酸交联壳聚糖纳米粒的制备及抗肿瘤评价研究
Masoud Farshbaf,Nasrin Gobakhlou,Muhammad Sarfraz et al.
Masoud Farshbaf et al.
Purpose: Chitosan nanoparticles (CNs) have directed considerable research efforts towards developing biocompatible, biodegradable, inexpensive and efficient particulate drug delivery systems. ...
Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic Vaccines [0.03%]
用于预防宫颈癌的纳米疫苗：克服传统治疗性疫苗局限性的可靠策略
Enwa Felix Oghenemaro,Safia Obaidur Rab,Ebraheem Abdu Musad Saleh et al.
Enwa Felix Oghenemaro et al.
Cervical cancer ranks fourth in terms of diagnosis and cancer-related deaths in women worldwide. Despite the approval of prophylactic vaccines against cervical cancers, these vaccines are not able to eradicate the existing ones. Therefore, ...
Impact of Elateriospermum tapos Supplementation on Leptin and Hypothalamic Signaling in Female Offspring of High-Fat Diet-Induced Obese [0.03%]
黄脂肪树素对高脂饮食诱导肥胖小鼠后代雌性子代瘦素及下丘脑信号传导的影响
Santhra Segaran Balan,Hasnah Bahari,Azrina Zainal Abidin et al.
Santhra Segaran Balan et al.
Purpose: The central nervous system plays a crucial role in regulating food intake and energy expenditure to maintain energy homeostasis in the body. With rising obesity rates, alternative therapeutic strategies, includin...
Vemurafenib Induces Senescent Phenotype with Increased Adhesion in BRAF Mutant A375 but not in Wild Type BRAF SK-MEL-2 Melanoma Cells [0.03%]
Vemurafenib诱导BRAF突变A375黑色素瘤细胞衰老并增加粘附力但不影响野生型BRAF SK-MEL-2细胞
Aleksandra Rashidovna Esimbekova,Vasiliy Dmitrievich Belenyuk,Andrey Anatolievich Savchenko et al.
Aleksandra Rashidovna Esimbekova et al.
Purpose: The present study aimed to determine the selective effects of BRAF V600E inhibitor on focal adhesion in melanoma cells with respect to their phenotypic reprogramming. ...
Small T Oncoprotein of Merkel Cell Polyomavirus Attenuates Cisplatin-Induced Apoptosis and Enhances E1, E6/E7, MMP-1, and Ki-67 Expression in HeLa Cervical Cancer Cells [0.03%]
默克尔细胞多瘤病毒小T癌基因蛋白通过抑制顺铂诱导的宫颈癌HeLa细胞凋亡增强增殖相关基因E1、E6/E7、MMP-1和Ki-67表达
Fatemeh Pakdel,Seyed Masoud Hosseini,Neda Soleimani et al.
Fatemeh Pakdel et al.
Purpose: Cervical cancer (CxCa) is primarily caused by high-risk human papillomaviruses (hrHPV), which disrupt p53 and pRb regulation, leading to uncontrolled growth and progression. Co-infection with polyomaviruses like ...
The Effect of Arsenic Trioxide and Its Combination with Oxaliplatin and Docetaxel on the Induction of Autophagy and Expression of LC3 and Beclin-1 Genes in AGS and MKN-45 Gastric Cancer Cell Lines [0.03%]
三氧化二砷及其与奥沙利铂和多西他赛联合应用对AGS和MKN-45胃癌细胞系自噬诱导及LC3、Beclin-1基因表达的影响
Shadi Babaei,Mohsen Nikbakht,Ahmad Majd et al.
Shadi Babaei et al.
Purpose: Apoptosis and autophagy play critical roles in the survival and regulation of cancer cells, with key genes serving dual purposes in these processes. Arsenic trioxide (ATO), oxaliplatin (OXA), and docetaxel (DOC) ...
c-Abl Inhibitors in Parkinson's: Exploring Hypotheses on Alpha-Synuclein Modulation [0.03%]
c-Abl抑制剂在帕金森病中的作用：探索α-突触核蛋白调节的假说
Jyutia Nargish,Hirok Jyoti Baishya,Piyong Sola
Jyutia Nargish
Parkinson's disease (PD) stands as the second most prevalent neurodegenerative disorder, impacting a global population estimated between 6 to 10 million individuals. The condition primarily arises from a dopamine deficiency and the presence...