Deep Learning-Based Drug Half-Life Classification to Enhance Drug Development and Pharmacokinetics [0.03%]
基于深度学习的药物半衰期分类以增强药物开发和药代动力学
Affaf Khaouane,Hadjer Barki,Samira Ferhat
Affaf Khaouane
Purpose: Predicting drug half-life is essential in pharmacokinetics (PK), influencing dosing strategies and guiding drug development. Traditional regression models estimate exact half-life values but are sensitive to phar...
Sulfur-Dependent Disulfide Bond Disruption in Insulin Resistance: A Hypothesis [0.03%]
硫依赖性二硫键裂解与胰岛素抵抗假说
Maher Monir Akl,Amr Ahmed
Maher Monir Akl
Angélica Sofía Martínez-Ramírez,José David Nuñez-Ríos,Ana Patricia Juárez-Mercado et al.
Angélica Sofía Martínez-Ramírez et al.
Ovarian carcinoma (OC) is the most lethal gynecological cancer worldwide. Around 95% of patients exhibit recurrence five years after treatment; 80% experience recurrence within 18 months after first-line treatment, and progression-free surv...
Hydrogel Micro/Nanostructures for the Delivery of Oncolytic Viruses: Overcoming Limitations and Improving Efficacy [0.03%]
用于传递溶瘤病毒的水凝胶微/纳米结构：克服局限性和提高疗效
Chou-Yi Hsu,Saade Abdalkareem Jasim,Jasur Alimdjanovich Rizaev et al.
Chou-Yi Hsu et al.
Oncolytic viruses (OVs) have attracted accumulating attention in cancer therapy owing to their ability to replicate in and kill tumor cells, resulting in the stimulation of immune responses for eradicating residual and distant malignant cel...
Pharmaco-EEG-Based Classification of Psychotropic Activity of a Novel Chromone-Containing Allylmorpholine in Rats [0.03%]
基于药理 EEG 的新型色酮含氨基吗啉的精神活性分类在大鼠中的研究
Yuriy I Sysoev,Nikita S Kurmazov,Darya D Shitc et al.
Yuriy I Sysoev et al.
Purpose: Chromone-containing allylmorpholines (CCAMs) are a promising class of compounds that have been shown to have a dose-dependent inhibition effect on locomotion in zebrafish (Danio rerio). However, experiments using...
Shilpa Chaudhary,Keerti Manocha,Praveen Malik et al.
Shilpa Chaudhary et al.
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2Dm) are increasingly recognized as interrelated metabolic disorders, each contributing to the other's progression. NAFLD, a leading cause of chronic liver disease globally, is ...
Nano-Engineered Cargo for Optimizing Oral Absorption of Tizanidine Nanostructured Lipid Carriers [0.03%]
纳米工程载药体系优化替扎尼定纳米脂质载体口服吸收研究
Mohammed A Bazuhair,Maha H Jamal,Rawabi A Alashari et al.
Mohammed A Bazuhair et al.
Purpose: Tizanidine (TNZ) is a muscle relaxant that works by blocking presynaptic neurons. Due to its inadequate solubility and low oral bioavailability, this medication is classified as a Biopharmaceutics Classification ...
Conditioned Medium from Estradiol-Primed Macrophages Mitigates Adjuvant-Induced Arthritis in Rats [0.03%]
雌二醇预处理的巨噬细胞培养上清液缓解大鼠佐剂性关节炎
Farshad Yadollahi,Seyyed Meysam Abtahi Froushani,Rahim Hobenaghi
Farshad Yadollahi
Purpose: Macrophages with an anti-inflammatory phenotype are critical for resolving inflammation and preventing chronic tissue injury. Estradiol is known to promote this favorable macrophage profile. This study evaluated ...
The Phenomenon of Antimicrobial Resistance in Southern Italy: An Overview of the Current Situation [0.03%]
意大利南部抗菌素耐药现象的现状概述
Stefano Ruga,Raffaele Petti,Mara Masullo et al.
Stefano Ruga et al.
Purpose: Antimicrobial resistance (AMR) is an escalating global health challenge with region-specific implications. This study investigated AMR prevalence in Southern Italy, with particular attention to demographic variab...
GAS5 Long Noncoding RNA Regulates CD20 Expression and Rituximab Response [0.03%]
GAS5长链非编码RNA调节CD20表达和利妥昔单抗应答
Mahbubeh Rojhannezhad,Zahra Abedi Kichi,Abbas Nikravesh et al.
Mahbubeh Rojhannezhad et al.
Purpose: Rituximab is the primary treatment for non-Hodgkin lymphoma (NHL), one of the most common cancers globally. One of the main challenges associated with rituximab therapy is the decline in its effectiveness over ti...