PI3K Signaling Pathway Inhibitor Affects Myeloma Cells in a Culture-Dependent Manner [0.03%]
PI3K信号通路抑制剂以培养方式依赖型的方式影响多发性骨髓瘤细胞
Mehrnaz Janfada,Sadaf Vahdat,Saeid Kaviani
Mehrnaz Janfada
Purpose: The survival and progression of multiple myeloma (MM) cells rely heavily on supportive factors and cells within the MM microenvironment, notably macrophages. The PI3K signaling pathway plays a crucial role in bot...
Bacteria Associated with Prostate Cancer Progression and New Strategy in the Treatment [0.03%]
与前列腺癌进展相关的细菌及新的治疗策略
Fathimath Ina Shareef,Kannan Subbaram,Razana Faiz et al.
Fathimath Ina Shareef et al.
Assessing the Potential of Generative Artificial Intelligence Models to Assist Experts in the Development of Pharmacokinetic Models [0.03%]
评估生成式人工智能模型在药代动力学建模方面的潜力辅助专家构建药代动力学模型
Sergio Sánchez-Herrero,Laura Calvet Liñan
Sergio Sánchez-Herrero
Purpose: This study explores the potential of generative AI models to aid experts in developing scripts for pharmacokinetic (PK) models, with a focus on constructing a two-compartment population PK model using data from H...
Dissolving Microneedle Patch Incorporated with Insulin Nanoparticles for The Management of Type-I Diabetes Mellitus: Formulation Development and in Vivo Monitoring [0.03%]
一种用于I型糖尿病管理的新型药物输送系统：载胰岛素纳米粒溶离型微针贴片的研究开发及在体评价
Bheemisetty Brahmam,Salwa,Dani Lakshman Yarlagadda et al.
Bheemisetty Brahmam et al.
Purpose: The present study aimed to fabricate microneedles (MNs) for transdermal delivery of insulin. Chitosan-conjugated carboxy phenyl boronic acid polymer was synthesized and characterized to load insulin in the form o...
Codelivery of Raloxifene and Rutin as PEGylated Nanoliposomes: Formulation, Characterization, and Prophylactic Activity Against Breast Cancer [0.03%]
作为PEG修饰的纳米脂质体输送雷洛昔芬和芸香苷：配方，定性及预防乳腺癌的作用
Maryam Abdulmaged Oleiwi,Ali Al-Samydai,Aya Y Al-Kabariti et al.
Maryam Abdulmaged Oleiwi et al.
Purpose: Breast cancer is the leading cause of cancer-related deaths among women. Chemotherapy faces challenges such as systemic toxicity and multidrug resistance. Advances in nanotechnology have led researchers to develo...
An Overview on Lipid Nanocapsules: Exploring the Role in Precision Cancer Treatment and Lymphatic Drug Distribution [0.03%]
脂质纳米囊壳概述：在精准癌症治疗和淋巴药物递送中的作用探讨
Mahesha Keerikkadu,Pragathi Devanand Bangera,Vamshi Krishna Tippavajhala et al.
Mahesha Keerikkadu et al.
Lipid nanocapsules (LNCs) are an emerging nanocarrier platform for cancer therapy as they can co-deliver multiple drugs, promote synergistic action, and provide targeted drug delivery. The phase inversion temperature (PIT) process is most u...
Lung Cancer Immunotherapy Approaches: From Clinical Testing to Future Advances [0.03%]
肺癌免疫疗法：从临床试验到未来进展
Mayuri Bhattacharyya,Suktilang Majaw
Mayuri Bhattacharyya
One of the major reason of deaths due to cancer globally is caused by lung cancer of which the two main types include non-small cell and small cell lung cancer. The onset of treatment-resistance in cancer cells offers a serious obstacle to ...
Synergistic Enhancement of Osimertinib Efficacy in Non-small Cell Lung Cancer Cells Through Epigallocatechin-3-Gallate: Mechanistic Insights Into YAP/TEAD/CTGF Axis Inhibition [0.03%]
表没食子儿茶素没食子酸酯通过抑制YAP/TEAD/CTGF轴增强非小细胞肺癌细胞中奥希替尼的疗效及机制研究
Ashwini Somayaji,Chakrakodi Shashidhara Shastry
Ashwini Somayaji
Purpose: Combinatorial therapies are essential for treating advanced non-small cell lung cancer (NSCLC), particularly overcoming resistance to third-generation epidermal growth factor receptor (EGFR) like osimertinib (OSI...
M2 Macrophages-Based Immunotherapy: A New Therapeutic Approach in Liver Fibrosis [0.03%]
基于M2型巨噬细胞的免疫疗法：肝纤维化治疗的新方法
Wahyu Widowati,Adilah Hafizha Nur Sabrina,Annisa Firdaus Sutendi et al.
Wahyu Widowati et al.
Liver fibrosis (LF) is a pathological condition resulting from a chronic inflammatory response to multiple etiological factors, including viral infections, excessive alcohol consumption, and metabolic disorders. The important role of macrop...
Inhibitory Effects of Citrus-Derived Flavonoids Hesperidin and Hesperetin on SARS-CoV-2 Spike-Mediated Syncytia Formation Using In Vitro Cell Model [0.03%]
柑橘类黄酮hesperidin和hesperetin通过体外细胞模型抑制SARS-CoV-2刺突介导的合胞体形成作用研究
Dennaya Kumara,Hayfa Salsabila Harsan,Endah Puji Septisetyani et al.
Dennaya Kumara et al.
Purpose: SARS-CoV-2 infection may lead to a worse prognosis in COVID-19 patients by inducing syncytia formation which implies intercellular transmission and immune evasion. Hesperidin (HSD) and hesperetin (HST) are two ci...