Drug-Drug/Drug-Excipient Compatibility Studies on Curcumin using Non-Thermal Methods [0.03%]
采用非热方法进行姜黄素药物与辅料相容性研究
Moorthi Chidambaram,Kathiresan Krishnasamy
Moorthi Chidambaram
Purpose: Curcumin is a hydrophobic polyphenol isolated from dried rhizome of turmeric. Clinical usefulness of curcumin in the treatment of cancer is limited due to poor aqueous solubility, hydrolytic degradation, metaboli...
Hypolipidemic activity of a natural mineral water rich in calcium, magnesium, and bicarbonate in hyperlipidemic adults [0.03%]
一种富含钙、镁和碳酸氢盐的天然矿泉水对高脂血症成人降血脂作用的影响研究
Naser Aslanabadi,Bohlool Habibi Asl,Babak Bakhshalizadeh et al.
Naser Aslanabadi et al.
Purpose: This study compared the effects of a mineral water rich in calcium, magnesium, bicarbonate, and sulfate and a marketed mineral water with a composition similar to that of urban water on the lipid profile of dysli...
Formulation and physicochemical characterization of buccoadhesive microspheres containing diclofenac sodium [0.03%]
含有硫酸氯已定的颊黏附微球的制备及物理化学性质研究
Mitra Jelvehgari,Hadi Valizadeh,Ramin Jalali Motlagh et al.
Mitra Jelvehgari et al.
Purpose: The present study involves preparation and evaluation of diclofenac buccal-mucoadhesive microparticles for prolongation of buccal residence time. ...
Elmira Zolali,Hadi Hamishehkar,Nasrin Maleki-Dizaji et al.
Elmira Zolali et al.
Purpose: Severe oxidative stress is an important event that occurs in patients with sepsis. The body has extensive and multiple defense mechanisms against the reactive oxygen species (ROS) produced during inflammation and...
Refaat Ahmed Saber,Ali Kamal Attia,Waheed Mohamed Salem
Refaat Ahmed Saber
Purpose: The aim of the present work is to study the thermal analysis of telmisartan and cilazapril. Methods: Thermogravimetry (TGA), d...
HPLC-Analysis of Polyphenolic Compounds in Gardenia jasminoides and Determination of Antioxidant Activity by Using Free Radical Scavenging Assays [0.03%]
高效液相色谱法分析栀子中的多酚类成分及其抗氧化活性研究
Riaz Uddin,Moni Rani Saha,Nusrat Subhan et al.
Riaz Uddin et al.
Purpose: Gardenia jasminoides is a traditional medicinal plant rich in anti-inflammatory flavonoids and phenolic compounds and used for the treatment of inflammatory diseases and pain. In this present study, antioxidant p...
Amelia Tero-Vescan,Gabriel Hancu,Mihaela Oroian et al.
Amelia Tero-Vescan et al.
Purpose: Indapamide is probably the most frequently prescribed diuretic drug, generally being used for the treatment of hypertension. It contains a chiral center in its molecule; is marketed as a racemic mixture; but ther...
Optimized condition for enhanced soluble-expression of recombinant mutant anabaena variabilis phenylalanine ammonia lyase [0.03%]
优化变异体ANK123可溶性表达条件提高外源大变色鱼腥藻苯丙氨酶产量的研究
Hossein Zarei Jaliani,Safar Farajnia,Yaghoub Safdari et al.
Hossein Zarei Jaliani et al.
Purpose: Recently discovered Anabaena variabilis phenylalanine ammonia lyase (AvPAL) proved to be a good candidate for enzyme replacement therapy of phenylketonuria. Outstanding stability properties of a mutant version of...
Induction of Apoptosis and Cytotoxic Activities of Iranian Orthodox Black Tea Extract (BTE) Using in vitro Models [0.03%]
采用体外模型诱导伊朗东正教红茶提取物(BTE)的细胞凋亡和细胞毒性的活性
Amirala Aghbali,Faranak Moradi Abbasabadi,Abbas Delazar et al.
Amirala Aghbali et al.
Purpose: Plant-derivate therapeutic agents can perform cancer chemotherapeutic activity through triggering apoptotic cell death. Our aim was to investigate the cytotoxic effects, induction of apoptosis, and the mechanism ...
Protective Effects of N-acetylcysteine Against the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes [0.03%]
N-乙酰半胱氨酸对新鲜分离的大鼠肝细胞内他汀类药物细胞毒性的保护作用
Narges Abdoli,Yadollah Azarmi,Mohammad Ali Eghbal
Narges Abdoli
Purpose: Hepatotoxicity is one of the most important side effects of the statins therapy as lipid-lowering agents. However, the mechanism(s) of hepatotoxicity induced by these drugs is not clearly understood yet, and no h...