Evaluating the Accuracy of Large Language Model (ChatGPT) in Providing Information on Metastatic Breast Cancer [0.03%]
评估大型语言模型（ChatGPT）在提供转移性乳腺癌信息的准确性
Ramakrishna Gummadi,Nagasen Dasari,D Sathis Kumar et al.
Ramakrishna Gummadi et al.
Purpose: Artificial intelligence (AI), particularly large language models like ChatGPT developed by OpenAI, has demonstrated potential in various domains, including medicine. While ChatGPT has shown the capability to pass...
Exploring the Interplay between the Warburg Effect and Glucolipotoxicity in Cancer Development: A Novel Perspective on Cancer Etiology [0.03%]
探讨瓦尔堡效应与糖脂毒性在癌症发生发展中的相互作用：癌症病因学的新视角
Maher Monir Akl,Amr Ahmed
Maher Monir Akl
The Warburg effect, first observed by Otto Warburg in the 1920s, delineates a metabolic phenomenon in which cancer cells exhibit heightened glucose uptake and lactate production, even under normoxic conditions. This metabolic shift towards ...
Ready to Eat Food: A Reason for Enhancement in Multidrug Resistance in Humans [0.03%]
即食食品中致病菌多重耐药性增强现象及其原因分析
Sheetal Negi,Sarika Sharma
Sheetal Negi
The increasing trend of consuming ready-to-eat (RTE) food has become a global phenomenon, and this has raised concerns about the potential negative impacts on human health. Recent studies have shown a correlation between the consumption of ...
Cytobiological Alterations Induced by Celecoxib as an Anticancer Agent for Breast and Metastatic Breast Cancer [0.03%]
塞来昔布作为抗癌药物对乳腺癌和转移性乳腺癌的细胞生物学改变的影响
Maher Monir Akl,Amr Ahmed
Maher Monir Akl
Breast cancer remains a formidable public health challenge worldwide, characterized by its initiation within the breast's diverse tissues, particularly the ducts and lobules. This malignancy is predominantly categorized into three subtypes ...
Investigating Functional and Folding Stability of an Engineered E. coli L-asparaginase Harboring Y176F/S241C Mutations [0.03%]
带有Y176F/S241C突变的工程化大肠杆菌L-天冬酰胺酶的功能和折叠稳定性研究
Mahrokh Dastmalchi,Maryam Hamzeh-Mivehroud,Hassan Rezazadeh et al.
Mahrokh Dastmalchi et al.
Purpose: L-asparaginase has been widely recognized as a critical component in the treatment of various types of lymphoproliferative disorders, since its introduction in 1960s. However, its use in some cases leads to aller...
Sex Differences on the Pharmacokinetics of Drugs for Children with Chronic Kidney Disease: A Narrative Review [0.03%]
儿童慢性肾脏病患者药物药代动力学的性别差异：综述文章
Toktam Faghihi,Farahnak Assadi
Toktam Faghihi
Effective optimal pharmacotherapy requires a comprehensive understanding of the drug's pharmacokinetic properties. Chronic kidney disease (CKD) influences medication pharmacokinetics. However, whether sex differences exist in the pharmacoki...
PGV-1 Causes Disarrangement of Spindle Microtubule Organization Resulting in Aberrant Mitosis in HLF and HuH6 Cells Associated with Altered MYCN Status [0.03%]
PGV-1通过改变MYCN状态导致HLF和HuH6细胞分裂中期染色体排列异常及有丝分裂缺陷
Nadzifa Nugraheni,Ummi Maryam Zulfin,Beni Lestari et al.
Nadzifa Nugraheni et al.
Purpose: The HLF and HuH-6 cell lines represent hepatocellular carcinoma (HCC) with different characteristics in chromosome content that may give different drug responses. Here, PGV-1 was intended to challenge the growth-...
Nanomedicine Strategies Utilizing Lipid-Based Nanoparticles for Liver Cancer Therapy: Exploring Signaling Pathways and Therapeutic Modalities [0.03%]
基于脂质纳米颗粒的纳米医学策略在肝癌治疗中的应用：探索信号通路和治疗方法
Fereshteh Asgharzadeh,Maryam Moradi Binabaj,Sahar Fanoudi et al.
Fereshteh Asgharzadeh et al.
Liver cancer, specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related deaths, following pancreatic cancer. The 5-year overall survival rate for HCC remains relatively low. Currently, there are multiple tre...
Menadione Sodium Bisulfite Loaded Rhamnolipid Based Solid Lipid Nanoparticle as Skin Lightener Formulation: A Green Production Beside In Vitro/In Vivo Safety Index Evaluation [0.03%]
绿色合成的癸糖脂基固态脂质纳米粒作为维生素K3皮肤美白剂的载体及其体内外安全性评价
Fatemeh Asadpour Panbehchouleh,Hossein Amani,Majid Saeedi
Fatemeh Asadpour Panbehchouleh
Purpose: In the current investigation, an ultrasonic approach was performed to produce menadione sodium bisulfite-loaded solid lipid nanoparticles (MSB-SLNs) with rhamnolipid as bio-surfactant, which aimed to increase the...
Dual-stage Acting Dendrimeric Nanoparticle for Deepened Chemotherapeutic Drug Delivery to Tumor Cells [0.03%]
用于深层递送化疗药物进入肿瘤细胞的两阶段作用树形纳米粒子
Mohammad Shahpouri,Mohammad Amin Adili-Aghdam,Hossein Mahmudi et al.
Mohammad Shahpouri et al.
Purpose: We report on the design of hypoxia-induced dual-stage acting dendrimeric nanoparticles (NPs) for selective delivery of two chemotherapeutic model drugs doxorubicin (DOX) and tirapazamin (TPZ) for deepened drug de...