An Open-Source Modular Bioreactor Platform for Cultivation of Synechocystis sp. PCC 6803 and Extraction of Intracellular Glucose [0.03%]
一种用于培养集胞藻6803和提取细胞内葡萄糖的开源模块化生物反应器平台
Ingie Baho,Yitong Tseo,Yuexuan Zu et al.
Ingie Baho et al.
Rising carbon emissions have intensified the demand for sustainable biomanufacturing systems. Algae like Synechocystis sp. PCC 6803 lend themselves as a promising photosynthetic machine for high carbon-capture while generating valuable biop...
Towards Computationally Guided Design and Engineering of a Neisseria meningitidis Serogroup W Capsule Polymerase with Altered Substrate Specificity [0.03%]
计算指导的脑膜炎奈瑟菌韦氏血清群荚膜多糖聚合酶突变体设计与工程化改造以改变底物特异性
Subhadra Paudel,James Wachira,Pumtiwitt C McCarthy
Subhadra Paudel
Heavy metal contamination of drinking water is a public health concern that requires the development of more efficient bioremediation techniques. Absorption technologies, including biosorption, provide opportunities for improvements to incr...
Evaluation of a Combined MHE-NMPC Approach to Handle Plant-Model Mismatch in a Rotary Tablet Press [0.03%]
评估结合预测状态校正的NMPC方法以处理旋转压片机中模型失配问题
Yan-Shu Huang,M Ziyan Sheriff,Sunidhi Bachawala et al.
Yan-Shu Huang et al.
The transition from batch to continuous processes in the pharmaceutical industry has been driven by the potential improvement in process controllability, product quality homogeneity, and reduction of material inventory. A quality-by-control...
Steve M Ruggiero,Minu R Pilvankar,Ashlee N Ford Versypt
Steve M Ruggiero
Tuberculosis (TB) is one of the most common infectious diseases worldwide. It is estimated that one-third of the world's population is infected with TB. Most have the latent stage of the disease that can later transition to active TB diseas...
Optimization of Stimulation Parameters for Targeted Activation of Multiple Neurons Using Closed-Loop Search Methods [0.03%]
基于闭环搜索方法的多神经元目标激活刺激参数优化
Michelle L Kuykendal,Stephen P DeWeerth,Martha A Grover
Michelle L Kuykendal
Differential activation of neuronal populations can improve the efficacy of clinical devices such as sensory or cortical prostheses. Improving stimulus specificity will facilitate targeted neuronal activation to convey biologically realisti...
Extracellular Vesicle Transportation and Uptake by Recipient Cells: A Critical Process to Regulate Human Diseases [0.03%]
细胞外囊泡运输及受体细胞摄取：调控人类疾病的关键过程
Zhi Hao Kwok,Chenghao Wang,Yang Jin
Zhi Hao Kwok
Emerging evidence highlights the relevance of extracellular vesicles (EVs) in modulating human diseases including but not limited to cancer, inflammation, and neurological disorders. EVs can be found in almost all types of human body fluids...
The Spectrum of Mechanism-Oriented Models and Methods for Explanations of Biological Phenomena [0.03%]
面向机制的生物现象解释模型与方法的谱系研究
C Anthony Hunt,Ahmet Erdemir,William W Lytton et al.
C Anthony Hunt et al.
Developing and improving mechanism-oriented computational models to better explain biological phenomena is a dynamic and expanding frontier. As the complexity of targeted phenomena has increased, so too has the diversity in methods and term...
Overview and Update on Methods for Cargo Loading into Extracellular Vesicles [0.03%]
外泌体装载货物的方法概述及更新
Yohan Han,Timothy W Jones,Saugata Dutta et al.
Yohan Han et al.
The enormous library of pharmaceutical compounds presents endless research avenues. However, several factors limit the therapeutic potential of these drugs, such as drug resistance, stability, off-target toxicity, and inadequate delivery to...
Prediction of Metabolite Concentrations, Rate Constants and Post-Translational Regulation Using Maximum Entropy-Based Simulations with Application to Central Metabolism of Neurospora crassa [0.03%]
基于最大熵模拟的代谢物浓度、速率常数及翻译后调节预测在Neurospora crassa中央代谢中的应用
William R Cannon,Jeremy D Zucker,Douglas J Baxter et al.
William R Cannon et al.
We report the application of a recently proposed approach for modeling biological systems using a maximum entropy production rate principle in lieu of having in vivo rate constants. The method is applied in four steps: (1) a new ordinary di...
Ultrasensitive Ti3C2TX MXene/Chitosan Nanocomposite-Based Amperometric Biosensor for Detection of Potential Prostate Cancer Marker in Urine Samples [0.03%]
用于检测尿液样本中潜在前列腺癌标志物的超灵敏Ti3C2TX MXene/壳聚糖纳米复合材料式安培生物传感器
Stefania Hroncekova,Tomas Bertok,Michal Hires et al.
Stefania Hroncekova et al.
Two-dimensional layered nanomaterial Ti3C2TX (a member of the MXene family) was used to immobilise enzyme sarcosine oxidase to fabricate a nanostructured biosensor. The device was applied for detection of sarcosine, a potential prostate can...