Turning Fluids into Data for Precision Oncology: A Multidisciplinary Tumor Board Approach to Malignant Pleural Effusions [0.03%]
从精准肿瘤学的角度将体液转化为数据：恶性胸腔积液的多学科肿瘤会诊治疗方法
Domenico Damiani,Ilaria Girolami,Esther Hanspeter et al.
Domenico Damiani et al.
Background: Malignant pleural effusion (MPE) represents a frequent and clinically challenging manifestation of advanced malignancy, particularly in metastatic non-small cell lung cancer (NSCLC). Its management requires integration of diagno...
BRAF Mutations in Myeloid Neoplasms: Prevalence, Co-Mutation Landscape, and Clinical Outcomes-A Comprehensive Review [0.03%]
髓系肿瘤中BRAF突变的流行率、共突变图谱及临床结局：综合回顾
Shehab F Mohamed,Ali Mohamed,Mohamed Fawzi Mudarres et al.
Shehab F Mohamed et al.
Background: BRAF is a core component of the RAS-MAPK signaling pathway and an established oncogenic driver in several solid tumors and selected hematologic malignancies. In myeloid neoplasms, BRAF mutations are rare, and their prevalence, m...
Giovanni Pratelli,Mauro Montalbano,Federica Affranchi et al.
Giovanni Pratelli et al.
Breast cancer (BC) is a highly heterogeneous genetic disease, comprising several subtypes with distinct features that significantly influence prognosis and treatment outcomes. Among these subtypes, triple-negative breast cancer (TNBC) is pa...
Mrgprb4-Lineage Neurons Participate in the Intervention of TENS Effects on Chronic Pain and Anxiety-like Symptoms in an Inflammatory Pain Mouse Model [0.03%]
Mrgprb4-谱系神经元参与了TENS干预炎症痛小鼠模型慢性疼痛和焦虑样症状的作用机制
Longhua Du,Hongyi Cheng,Jiamian Zhang et al.
Longhua Du et al.
Background: Mas-related G-protein-coupled receptor b4 (Mrgprb4)-lineage neurons in the peripheral nervous system are a type of C fibers in hairy skin. Our prior work demonstrated that these neurons respond to both noxious and innocuous mech...
EEG Time-Frequency Clustering Reveals Spectral Signatures of Glutamatergic and Cholinergic Activities and Their Interrelations [0.03%]
基于时间-频率聚类的谷氨酸能和胆碱能活动及其相互作用的脑电特征研究
Vasily Vorobyov,Alexander Deev
Vasily Vorobyov
Background: The discovery of electroencephalogram (EEG) biomarkers of direct transmitter-receptor interactions in studies of neurotransmitter mechanisms underlying brain function remains relevant. Recently, EEG "signatures" of monoaminergic...
Bridging the Precision Gap in Rheumatoid Arthritis: Spatial Transcriptomics, Spatial Proteomics, and Artificial Intelligence in Precision Health [0.03%]
弥合风湿性关节炎精准医疗差距：空间转录组学、空间蛋白组学和人工智能的应用
Maliha Mashkoor,Shihua Zhang,Allan Stensballe
Maliha Mashkoor
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by complex immune cell associations and continuous joint damage. Personalized clinical assessment and treatment options for RA remain hindered by a precision gap due to...
Targeting the Glutamine Transporter SLC1A5 Enhances Sensitivity of Acute Myeloid Leukemia to MLN4924 [0.03%]
靶向谷氨酰胺转运体SLC1A5提高急性髓系白血病对MLN4924的敏感性
Yin Wang,Yuancheng Guo,Xiao Tang et al.
Yin Wang et al.
Background/Objectives: Acute myeloid leukemia (AML) remains a hematologic malignancy with poor prognosis. The neddylation inhibitor MLN4924 has demonstrated potent anti-leukemic activity in preclinical models, yet its clinical translation f...
Innovative Inclusion Complexes Clotrimazole: Hydroxypropyl-β-Cyclodextrin-Modified Polyurethane Networks as Carriers for Slow Drug Delivery [0.03%]
新型包合物克霉唑：羟丙基-β-环糊精修饰的聚氨酯网络作为控释载体
Suzana M Cakić,Snežana S Ilić-Stojanović,Ljubiša B Nikolić et al.
Suzana M Cakić et al.
Background/Objectives: Inclusion complexes among drugs and cyclodextrin-modified polymers are a topic of recent interest in pharmaceutical research and industry as they might expand the solubility, bioavailability, and stability of the gues...
Integration of RNA Editing into Multiomics Machine Learning Models for Predicting Drug Responses in Breast Cancer Patients [0.03%]
整合RNA编辑的多组学机器学习模型预测乳腺癌患者的药物反应
Yanara A Bernal,Alejandro Blanco,Karen Oróstica et al.
Yanara A Bernal et al.
Background: The integration of multi-omics data, such as genomics and transcriptomics, into artificial intelligence models has advanced precision medicine. However, their clinical applicability remains limited due to model complexity. We in...
Treatment Priorities in Craniopharyngioma: Perspectives of Survivors and Caregivers [0.03%]
颅咽管瘤治疗的优先级：幸存者和护理者的观点
Nathalie Kayadjanian,Eugenie A Hsu
Nathalie Kayadjanian
Background/Objectives: While the number and severity of comorbidities affecting survivors of craniopharyngioma (CP) are well documented, little is known about the perspectives of caregivers and survivors regarding treatment priorities. This...