Identification and Functional Validation of PTH2R as a Therapeutic Target in Lung Adenocarcinoma [0.03%]
肺腺癌治疗靶点PTH2R的鉴定及其功能验证
Changmin Liu,Yongfu Wang,Wei Liu et al.
Changmin Liu et al.
Background: One of the main causes of cancer-related mortality globally is lung adenocarcinoma (LUAD), necessitating the development of novel therapeutic targets. The parathyroid hormone type 2 receptor (PTH2R) exhibits differential express...
Aortic Valve Annular Properties in Cardiac Amyloidosis-Insights from the Three-Dimensional Speckle Tracking Echocardiographic MAGYAR-Path Study [0.03%]
基于三维斑点追踪超声心动图的MAGYAR-Path研究中心脏淀粉样变性患者的主动脉瓣环特性
Attila Nemes,Nóra Ambrus,Zita Borbényi
Attila Nemes
Introduction. The etiology of cardiac amyloidosis (CA) involves the systemic or localized deposition of misfolded amyloid proteins within the myocardial interstitium and valvular structures. The primary objective of this study was to employ...
New Advances in Cardiovascular Drugs: In Memory of Professor Akira Endo [0.03%]
心血管药学的新进展——谨纪念Akira Endo教授
Alfredo Caturano
Alfredo Caturano
In this Special Issue, we honor the memory of a giant within cardiovascular pharmacology, Professor Akira Endo, whose scientific vision profoundly transformed the prevention and treatment of cardiovascular disease [...].
Heart Failure in the Molecular Era: Redefining Our Understanding of Disease Mechanisms and Perspectives [0.03%]
分子时代的心力衰竭：重新定义疾病机制和展望疾病的视角
Manuel Mallol-Simmonds,Alfredo Parra-Lucares,Ivan Canete et al.
Manuel Mallol-Simmonds et al.
Heart failure (HF) is a global health challenge characterized by the heart's inability to satisfy metabolic demands, driven by renin-angiotensin-aldosterone system (RAAS) overactivation, a neurohormonal imbalance, and emerging mechanisms li...
The Synthetic Extracellular Matrix as a Maestro of the In Vitro Stem Cell Niche: Orchestrating Fate and Function [0.03%]
合成细胞外基质作为体外干细胞生态位的指挥者：命运和功能的协调调控
Subhajit Giri,Pratyush Rajesh
Subhajit Giri
Human-induced pluripotent stem cells (hiPSCs) have an innate ability to differentiate into the three germ layers: the ectoderm, endoderm, and mesoderm. By using targeted differentiation methods and carefully controlling growth factors, morp...
Identification and Validation of Signature Genes in Invasiveness-Associated Modules of Nonfunctioning Pituitary Adenomas [0.03%]
非功能性垂体腺瘤侵袭相关模块特征基因的识别与验证
Xin Ma,Hongyu Wu,Yu Zhang et al.
Xin Ma et al.
Background: Invasive non-functional pituitary adenomas (NFPAs) are associated with high recurrence and unfavorable clinical outcomes, yet their underlying molecular mechanisms remain incompletely understood. This study aimed to identify rob...
Aortic Elastic Properties and Albumin-Based Inflammatory Indices in Dyspneic Third-Trimester Pregnant Women: A Prospective Observational Study [0.03%]
III trimester孕期呼吸困难孕妇的主动脉弹性特征及白蛋白基炎症指标：前瞻性观察研究
Birsen Ertekin,Hatice Eyiol,Azmi Eyiol et al.
Birsen Ertekin et al.
Background: Dyspnea is a frequent complaint during pregnancy and is often considered a benign physiological finding; however, it may also reflect underlying subclinical cardiovascular alterations. Pregnancy-related vascular remodeling and l...
Focusing on Prostate-Specific Membrane Antigen in Precision Diagnosis and Treatment of Prostate Cancer [0.03%]
聚焦前列腺特异性膜抗原的前列腺癌精准诊疗
Xinyi Ren,Lingling Zhang,Ran An et al.
Xinyi Ren et al.
Prostate cancer (PCa) is the most common malignant tumor of the male genitourinary system, and its incidence and mortality have shown a marked global increase in recent years. Prostate-specific membrane antigen (PSMA), a type II transmembra...
Effect of Vitamin D3 on Transected and Crushed Injuries in Rat Sciatic Nerve Healing [0.03%]
维生素D3对大鼠坐骨神经切断与压迫伤修复的影响
Inanc Dogan Cicek,Handan Derebasinlioglu,Ayse Demirkazik et al.
Inanc Dogan Cicek et al.
Background: Peripheral nerve injury can happen for a variety of causes. Despite major breakthroughs in microsurgery, nerve repair results are not always sufficient. Methods: Thirty-two Wistar albino rats were split into four groups: primary...
Periodontitis-Induced Immune Reprogramming: Implications for Cancer Immunotherapy Response [0.03%]
牙周炎引起的免疫重编程：对癌症免疫治疗反应的影响
Claudia Florina Bogdan-Andreescu,Ștefan-Dimitrie Albu,Dan Alexandru Slăvescu et al.
Claudia Florina Bogdan-Andreescu et al.
Background: Chronic periodontitis is a prevalent inflammatory disease. It goes beyond the oral cavity, exerting systemic immunomodulatory effects through continuous low-grade inflammation, microbial dysbiosis, and cytokine spillover. Accumu...