Dry Eye Disease: Bridging Systemic Inflammation, Ocular Surface Biology, and Clinical Innovation [0.03%]
干眼病：系统性炎症、眼表生物学和临床创新之间的联系
Liat Gantz
Liat Gantz
Dry eye disease (DED) is a prevalent and complex disease of the ocular surface [...].
Mitochondrial Dysfunction in the Inflammatory Process of Neurodegenerative Diseases [0.03%]
神经退行性疾病炎症过程中线粒体功能障碍的作用
Salvatore Nesci
Salvatore Nesci
Neurodegenerative diseases share a mitochondrial-immune axis in which impaired oxidative phosphorylation reshapes neuronal metabolism and drives chronic inflammation. Complex I play a redox gatekeeper role at the coenzyme Q (CoQ) junction: ...
Immune-Mediated Colitis Induced by Immune Checkpoint Inhibitors: Pathophysiology, Clinical Management, and the Emerging Role of Fecal Microbiota Transplantation [0.03%]
免疫检查点抑制剂诱导的免疫介导性结肠炎：发病机制、临床处理及粪便菌群移植的新角色
Zeljka Belosic Halle,Vedran Tomasic,Alen Biscanin et al.
Zeljka Belosic Halle et al.
Background/objectives: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of various malignancies, but their use is frequently accompanied by immune-related adverse events, among which immune-mediated c...
Carboxylesterase 2-Engineered Stem Cell Therapy Shows Superior Efficacy over Cytosine Deaminase in Castration-Resistant Prostate Cancer [0.03%]
以去势抵抗性前列腺癌小鼠模型为对象的治疗效果研究：丙酮酸羧化酶2工程干细胞比胸苷脱氨酶细胞的效果更佳
Jae Heon Kim,Miho Song,Sang Hun Lee et al.
Jae Heon Kim et al.
Purpose: Castration-resistant prostate cancer (CRPC) responds poorly to conventional chemotherapy. We evaluated a cell-based enzyme-prodrug therapy using adipose-derived stem cells (ADSCs) engineered to express cytosine deaminase (CD) or ca...
Thermal-Inflammatory Index (TI): An Integrated Biomarker of Severity and Prognosis in Chronic Lower-Limb Ulcers [0.03%]
慢性下肢溃疡严重程度和预后的综合生物标志物热-炎症指数(TI)
Bartosz Molasy,Małgorzata Wrzosek
Bartosz Molasy
Background/Objectives: Chronic lower-limb ulcers of mixed etiology are characterized by impaired microcirculation and persistent inflammation, leading to delayed healing, frequent hospitalizations, and a high risk of limb loss. While infrar...
Clinical and Instrument-Based Evaluation of Plasma IQ Microcurrent Radiofrequency for Periorbital Skin Rejuvenation [0.03%]
微电流射频（Plasma IQ）治疗用于眼周皮肤年轻化临床及仪器评价
Paweł Kubik,Wojciech Gruszczyński,Aleksandra Pawłowska et al.
Paweł Kubik et al.
Background: Non-surgical procedures utilizing microcurrent radiofrequency (RF) represent a non-invasive option for patients experiencing skin laxity and loss of firmness due to aging, hormonal changes, or weight fluctuations. Such treatment...
Peptides and Amino Acids in Drug Development: Where We Stand and Where We Must Go [0.03%]
肽和氨基酸在药物研发中的现状与未来方向
Siva S Panda
Siva S Panda
Peptides are now a key part of modern drug development, transforming the industry at an extraordinary rate [...].
Redefining Idiopathic Normal Pressure Hydrocephalus Using AI-Driven Brain Volumetry [0.03%]
利用人工智能驱动的脑体积测量重新定义特发性正常压力脑积水
Juan Sahuquillo,Murad Al-Nusaif,Aasma Sahuquillo-Muxi et al.
Juan Sahuquillo et al.
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible cause of gait disturbance and cognitive impairment in older adults, yet its diagnosis remains challenging and controversial. The core difficulty lies in distinguish...
A Novel Frameshift Mutation in SLC20A2 in a Korean Patient with Primary Brain Calcification, Parkinsonism and Memory Impairment [0.03%]
SLC20A2的新移码突变在一名以原发性脑钙化、帕金森综合征和记忆障碍的韩国患者中的研究
Eva Bagyinszky,Minju Kim,Young Ho Park et al.
Eva Bagyinszky et al.
Objectives: The patient presented various neurological symptoms in her 50s, such as memory issues, insomnia, depression, and motor impairment. Diverse investigations were performed to identify the underlying causes on her...
Reconsidering Carotid Artery Stenting for Asymptomatic Carotid Stenosis in the Era of Endovascular Evolution [0.03%]
经血管内治疗时代对无症状颈动脉狭窄患者行颈动脉支架植入术的再思考
Chloe DeYoung,Brandon Lucke-Wold
Chloe DeYoung
Management strategies in asymptomatic carotid artery stenosis are largely centered on intensive medical management, with carotid revascularization via endarterectomy or carotid artery stenting being reserved for select patients. This decisi...