Quercetin Ameliorates Comorbid Insomnia in Diarrhea-Predominant Irritable Bowel Syndrome via the PI3K/AKT/NF-κB Signaling Pathway [0.03%]
檞皮素通过PI3K/AKT/NF-κB信号通路改善以腹泻为主的肠易激综合征共病性失眠
Guangming Liu,Xiangpan Kong,Yiru Zhao et al.
Guangming Liu et al.
Background: Chronic insomnia disorder (CID) frequently coexists with diarrhea-predominant irritable bowel syndrome (IBS-D), a comorbidity characterized by gut-brain axis dysfunction and persistent inflammatory activation. However, the molec...
Disease-Causing Mechanisms and Therapeutic Targets in Infectious Diseases: Implications for Clinical Management and Public Health [0.03%]
传染病的致病机制与治疗靶点：对临床诊治和公共卫生的影响
Kristina Sejersen,Susanne Sütterlin,Anders O Larsson
Kristina Sejersen
Infectious diseases remain a major cause of mortality and disability worldwide. This burden is driven, in part, by antimicrobial resistance (AMR) and the re-emergence of epidemic and pandemic threats, underscoring the need for translational...
Comparative Clinicopathological Features and p16 Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Cervix: A Single-Center Retrospective Cohort Study in Saudi Arabia (2020-2024) [0.03%]
沙特阿拉伯（2020-2024）单中心回顾性队列研究中宫颈鳞状细胞癌和腺癌的临床病理特征及p16表达的比较
Emad Alqassim,Mashael J Abu Alola,Ahmad Y Alqassim et al.
Emad Alqassim et al.
Background: Cervical cancer remains a major global health burden, with squamous cell carcinoma (SCC) and adenocarcinoma (ADC) representing the two predominant histological subtypes. Comparative clinicopathological patterns between SCC and A...
Integrated Evaluation of Corneal Damage, Goblet Cell Remodeling and Inflammatory Response in a Murine Model of Environmental Dry Eye Disease (DED) [0.03%]
环境因素诱导干眼病小鼠模型中角膜损伤、杯状细胞重塑及炎症反应的综合评价
Alessandro Vitola,Gloria Astolfi,Chiara Tugnoli et al.
Alessandro Vitola et al.
Background: Dry Eye Disease (DED) is a multifactorial disorder characterized by tear film instability and ocular surface inflammation. Murine models based on environmental stress are widely used to mimic evaporative DED, although many focus...
Diagnostic and Therapeutic Options in Myocarditis and Inflammatory Cardiomyopathy [0.03%]
心肌炎和炎症性心肌病的诊断和治疗选项
Heinz-Peter Schultheiss,Felicitas Escher,Ganna Aleshcheva et al.
Heinz-Peter Schultheiss et al.
Myocarditis and inflammatory cardiomyopathy are inflammatory diseases of the heart muscle that can have both infectious and non-infectious causes. They can be caused by an unresolved viral infection or other infection, or they can be autoim...
Clinical Characteristics and Predictors of Glycemic Control During the First 24 Months After Diagnosis of Type 1 Diabetes [0.03%]
新诊断1型糖尿病患者24个月内的临床特征和血糖控制的影响因素
Selina Löffler,Fabio Frigo,Daniel Hochfellner et al.
Selina Löffler et al.
Background: Long-term glycemic control in type 1 diabetes (T1D) varies substantially among affected individuals, but the role of baseline characteristics at diagnosis and their association with later glycemic control remain incompletely und...
An Overview of Vascular Compression Syndromes and Associations with Autonomic Dysfunction: A Review [0.03%]
血管压迫综合征及与自主神经功能障碍关联的综述性文章
Brandon M Davis,Petra Rantanen,Grace Seo et al.
Brandon M Davis et al.
Background: Vascular compression syndromes are increasingly recognized as underdiagnosed contributors to morbidity in patients exhibiting dysautonomia. Underlying vascular compression syndromes affecting the head and neck, abdomen, pelvis, ...
Pre-Clinical Models of Traumatic Brain Injury-A Narrative Review Towards "Animal Neuro-ICUs" [0.03%]
向“动物神经ICU”的前期创伤性脑损伤模型的叙述性回顾
Franziska Münz,Andrea Hoffmann,Michael Gröger et al.
Franziska Münz et al.
The presence of traumatic brain injury (TBI) is a critical determinant of post-traumatic mortality and morbidity. Not only is TBI one of the leading causes of death among severely injured patients, but it also substantially impacts long-ter...
Integrative Transcriptomics and Machine Learning Reveal the Association of CBX4 with Inflammation in Ulcerative Colitis as a Potential Epigenetic Regulator [0.03%]
整合转录组学和机器学习揭示CBX4在溃疡性结肠炎中作为潜在表观遗传调节因子与炎症的关系
Xiaohan Ma,Guangpeng Liu,Tingting Gong et al.
Xiaohan Ma et al.
Background/Objectives: Epigenetic factors are increasingly recognized to contribute to the pathogenesis of intestinal diseases, yet the precise mechanisms through which these factors influence ulcerative colitis (UC) remain poorly understoo...
Heat Shock Protein 70 Deficient Mice Exhibit Reduced Psoriasis-like Skin Inflammation [0.03%]
热休克蛋白70缺陷小鼠出现类似银屑病的皮肤炎症减少现象
Aikaterini Kalantidou,Maria Kostakou,Michail Deiktakis et al.
Aikaterini Kalantidou et al.
Background/Objectives: Psoriasis is a chronic, systemic, and multifactorial disease affecting approximately 1-2% of the Caucasian population. It is characterized by distinct histopathological features, including epidermal hyperplasia and in...