Progressive Aortic Regurgitation After Impella Bridge-to-LVAD: A Two-Year Cohort Analysis [0.03%]
Impella心室辅助转流期间发生进行性主动脉瓣反流的两年队列分析
Attila Nemeth,Aron Frederik Popov,Rodrigo Sandoval Boburg et al.
Attila Nemeth et al.
Background/Objectives: Impella support is increasingly utilized as a crucial bridge to durable left ventricular assist device (LVAD) in patients with refractory cardiogenic shock. However, the transvalvular path of the Impella catheter rais...
Ferulic Acid Alleviates Chemotherapy-Induced POI by Targeting the Grp78 and Perk-eIF2α-ATF4-CHOP Pathway to Attenuate Endoplasmic Reticulum Stress [0.03%]
金丝桃素通过靶向Grp78和Perk-eIF2α-ATF4-CHOP通路减轻内质网应激从而缓解化疗诱导的POI
Fan Li,Yanjing Huang,Zhuo Liu et al.
Fan Li et al.
Backgrounds: Premature ovarian insufficiency (POI) is a clinical syndrome characterized by premature ovarian dysfunction, amenorrhea, and infertility. Ferulic acid (FA) is a prominent bioactive phenolic compound derived from traditional Chi...
FedIHRAS: A Privacy-Preserving Federated Learning Framework for Multi-Institutional Collaborative Radiological Analysis with Integrated Explainability and Automated Clinical Reporting [0.03%]
FedIHRAS：一种用于多机构协作放射学分析的隐私保护联合学习框架（具备可解释性和自动化临床报告功能）
André Luiz Marques Serrano,Gabriel Arquelau Pimenta Rodrigues,Guilherme Dantas Bispo et al.
André Luiz Marques Serrano et al.
Background/Objectives: Federated learning has emerged as a promising paradigm for enabling collaborative artificial intelligence in healthcare while preserving data privacy. However, most existing frameworks focus on isolated tasks and lack...
Primary Cilia Are Required for Efficient BMP Signaling in Traumatic Heterotopic Ossification [0.03%]
主纤毛能够有效促进创伤后异位骨化的BMP信号转导作用
Xinyuan Yuan,Saman Toutounchi,Susan F Law et al.
Xinyuan Yuan et al.
Background/Objectives: Heterotopic ossification (HO), the aberrant formation of bone within soft tissues, arises either from rare genetic mutations or more commonly from traumatic insults. It is a major cause of morbidity not only in indivi...
Advances in SRNS Gene Research: From Precision Classification to Precision Diagnosis and Treatment [0.03%]
SRNS基因研究进展：从精准分类到精准诊治
Yuhong Ye,Limin Huang,Haidong Fu et al.
Yuhong Ye et al.
To clarify the genetic classification, diagnostic strategies, and precision treatment pathways of steroid-resistant nephrotic syndrome (SRNS), this review systematically reviews the genetic stratification system of SRNS by integrating recen...
Advances in Bone-on-a-Chips for In Vitro Modeling of Bone Physiology and Pathology [0.03%]
体外骨生理和病理模型的芯片骨骼技术研究进展
Xiuyun Cheng,Mingxia Lu,Ming Ma et al.
Xiuyun Cheng et al.
Bone is a dynamic and multifunctional tissue that provides mechanical support, regulates mineral homeostasis, supports hematopoiesis, and relies on complex interactions among multiple cell types. The increasing incidence of bone-related dis...
Management and Prognosis of Anti-MDA5 Dermatomyositis: Insights from a National Multicenter Cohort [0.03%]
抗MDA5皮肌炎的管理及预后：来自全国多中心队列的启示
Sándor Mogyoróssy,Zoltán Griger,Tünde Tarr et al.
Sándor Mogyoróssy et al.
Background: Anti-melanoma differentiation-associated gene 5 (anti-MDA5) positive dermatomyositis is a distinct subset of idiopathic inflammatory myopathies (IIMs), often associated with unique cutaneous features and interstitial lung diseas...
A Review of Gut Microbiota Dynamics: From Healthy Gestation to Gestational Diabetes in Human and Mouse Models [0.03%]
从健康妊娠到妊娠期糖尿病的人类和小鼠模型的肠道菌群动态综述
Dat Da Ly,Bryony A McNeill,Kathryn Aston-Mourney et al.
Dat Da Ly et al.
Over the past decades, gut microbiota has emerged as a critical modulator of human health and disease. Pregnancy involves substantial microbiota remodelling that influences offspring development, yet mechanisms linking maternal microbiota c...
Age-Dependent Systemic Regulation of C1q/TNF-Related Protein 3 and Progranulin in Patients with Cystic Fibrosis: Biomarkers or Therapeutic Targets? [0.03%]
囊性纤维化患者系统中C1q/TNF相关蛋白3和前列腺素的年龄依赖性全身调节：生物标志物还是治疗靶点？
Andreas Schmid,Miriam Arians,Caroline Gunchick et al.
Andreas Schmid et al.
Background/Objectives: C1q/TNF-related protein 3 (CTRP3), progranulin (PGRN), and chemerin are adipokines that participate in systemic inflammation. This study systematically examined adipokine levels in cystic fibrosis patients of differen...
Pulmonary Arterial Hypertension: From Molecular Basis to Therapeutic Approaches [0.03%]
肺动脉高压：从中分子基础到治疗策略
Rui Adão
Rui Adão
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pathological remodeling of the pulmonary vasculature, ultimately leading to right heart failure and premature death [...].