Antidepressant-Induced Apathy in Adolescents with a Depressive Episode While Taking Sertraline: Results of 8-Week Observational Study with Pharmacogenetic Testing for CYP2C19 [0.03%]
氟西汀所致青少年抑郁发作患儿情感淡漠的观察性研究(为期8周并进行CYP2C19基因分型)
Dmitriy V Ivashchenko,Sergey V Grass,Vitaliy V Sobur et al.
Dmitriy V Ivashchenko et al.
Objectives. The aim of our study was to track changes in ODQ scores in adolescents with depressive episodes taking sertraline, depending on CYP2C19 polymorphisms. Methods. This study included 88 adolescents (88% were female) aged 12-17 who ...
Anti-Angiogenic Features of Endostatin in Obesity, Liver Fibrosis, and Hepatocellular Carcinoma [0.03%]
恩度在肥胖、肝纤维化和肝细胞癌的抗血管生成特性
Thomas Grewal,Christa Buechler
Thomas Grewal
Background/objectives: Endostatin is a cleavage product of collagen XVIII and a potent anti-angiogenic factor. Angiogenesis is essential for adipose tissue growth and contributes to liver fibrosis and cancer, suggesting a potential therapeu...
En-Bloc Resection of Stage T4 Non-Small Cell Lung Cancer with Direct Spinal Invasion: Technical Considerations and Comprehensive Literature Review [0.03%]
一期切除直接侵袭脊柱的T4期非小细胞肺癌的技术考量和综合文献回顾
Wei-Ting Lee,Ke-Cheng Chen,Ching-Yao Yang et al.
Wei-Ting Lee et al.
Historically, stage T4 non-small cell lung cancer (NSCLC) with direct spinal invasion was considered a definitive surgical contraindication due to the perceived inability to achieve negative margins without catastrophic morbidity. This para...
Do Serum Brain Biomarkers Differentiate the Hemorrhagic Head Injury Lesion Phenotypes? An Interim Analysis of an On-Going Randomized Clinical Trial [0.03%]
血清脑部生物标志物能区分出血性颅脑损伤的不同类型病变吗？一项正在进行的随机临床试验的中期分析结果
Ayman El-Menyar,Naushad Ahmad Khan,Mohammad Asim et al.
Ayman El-Menyar et al.
Background: Traumatic head injury (THI) includes a diverse range of hemorrhagic brain lesions (HBL), which are distinct phenotypes with characteristic pathophysiological mechanisms. Computed tomography (CT) is the cornerstone of the initial...
Comparative Effects of Mineralocorticoid Receptor Antagonism on Organ Dysfunction in COVID-19-Associated ARDS [0.03%]
盐皮质激素受体拮抗剂对新型冠状病毒肺炎相关性ARDS器官功能障碍影响的比较效应
Güleren Yartaş Dumanlı,Olcay Dilken,Oktay Demirkıran et al.
Güleren Yartaş Dumanlı et al.
Background/Objectives: Diuretics are recommended for hemodynamically stable patients with COVID-19-associated acute respiratory distress syndrome (ARDS) who have a positive fluid balance. However, furosemide use may be limited by hypokalemi...
Cumambrin B Alleviates Sepsis-Associated Acute Lung Injury by Activating the Nrf2/HO-1 Pathway [0.03%]
姜黄素溴铵B通过激活Nrf2/HO-1信号通路缓解内毒素致急性肺损伤的作用及机制研究
Yuemei Que,Dandan Ruan,Minxia Xu et al.
Yuemei Que et al.
Background: Sepsis-associated acute lung injury (SA-ALI) is a prevalent complication observed in patients with severe infection, characterized primarily by uncontrolled inflammatory response. Cumambrin B (CB) is a natural sesquiterpene lact...
Takefumi Kimura,Takanobu Iwadare,Shun-Ichi Wakabayashi
Takefumi Kimura
This Editorial introduces the Special Issue titled "Liver Fibrosis: Molecular Mechanisms, Potential Therapeutic Targets and Clinical Biomarkers" in Biomedicines [...].
Spatial Distribution of K13-Positive Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis [0.03%]
特发性肺纤维化患者气道上皮中K13阳性细胞的时空分布特点研究
Fei Teng,Qi Zheng,Yansong Bai et al.
Fei Teng et al.
Background: The progression of idiopathic pulmonary fibrosis (IPF) involves distal airway remodeling and bronchiolization; however, the mechanisms driving these changes, particularly the contributions of epithelial stem cells, are not fully...
Human Umbilical Cord Mesenchymal Stem Cells Protect Against Steroid-Induced Osteonecrosis of the Femoral Head Through Hippo Pathway [0.03%]
人源脐带间充质干细胞通过Hippo信号途径防治糖皮质激素诱导的股骨头坏死
Hengte Xing,Wenxiang Cai,Junwen Chen et al.
Hengte Xing et al.
Background: Glucocorticoids (GCs) are a key pathogenic factor in steroid-induced avascular necrosis of the femoral head (SANFH). GCs can directly damage bone microvascular endothelial cells (BMECs), leading to impaired intraosseous blood su...
Targeted Interference with USF2 Binding to the SERPINE1 Proximal Promoter E-Box in Dual Mutant p53R282Q,H179Y Human Keratinocytes Inhibits Serum-/TGF-β1-Induced SERPINE1 Expression and Stimulates Epithelial Cell Proliferation [0.03%]
靶向干扰USF2与PAI-1近端启动子E盒结合可抑制双突变型p53R282Q,H179Y人类角质细胞中的血清/TGF-β1诱导的PAI-1表达并促进上皮细胞增殖
Stephen P Higgins,Ralf-Peter Czekay,Craig E Higgins et al.
Stephen P Higgins et al.
The SERPINE1 gene encodes the serine protease inhibitor plasminogen activator inhibitor type-1 (PAI-1), a major negative regulator of the plasmin-dependent pericellular proteolytic cascade and a crucial determinant in the program of stromal...