Hypertriglyceridaemia-Associated Acute Pancreatitis: Pathophysiological Insights and Advances in Clinical Management [0.03%]
高甘油三酯血症性急性胰腺炎：病理生理学见解与临床管理进展
Yuying Li,Xinran Zhou,Yongjian Wen et al.
Yuying Li et al.
Hypertriglyceridaemia (HTG) is an increasingly recognised aetiology of acute pancreatitis (AP), driven by the global rise in metabolic disorders. Although traditionally defined by triglyceride levels ≥ 1000 mg/dL, emerging evidence suggest...
IV-EVE: EVE for Injection-ADME, Pharmacokinetic and Toxicological Evaluation for Novel Deciparticle EVE Formulation [0.03%]
IV-EVE：用于新型欺骗粒子EVE制剂的注射-吸收、分布、代谢、排泄及毒性评价
Wen-Han Chang,Nancy Chang,Sheng-Hao Min et al.
Wen-Han Chang et al.
Background: Oral everolimus (Oral-EVE; EVE, Afinitor®) is an effective therapy for multiple malignancies, including HR-positive/HER2-negative breast cancer, but its clinical use is limited by low and variable oral bioavailability as well a...
Amniotic Biologics for Knee Osteoarthritis: Promise, Evidence, and Unmet Needs-A Narrative Review [0.03%]
胎盘生物制剂治疗膝关节骨性关节炎：前景、证据及未满足需求-叙事综述
Kuan-Hao Chen,Wen-Tien Wu,Ru-Ping Lee et al.
Kuan-Hao Chen et al.
Background: Knee osteoarthritis (KOA) is a leading cause of chronic pain and functional disability worldwide. Despite the widespread use of intra-articular (IA) corticosteroids and hyaluronic acid (HA), their long-term efficacy remains limi...
Screening and Treatment Intervention for Insulin Resistance/Hyperinsulinemia in the General Population to Prevent Heart Failure or Slow Its Worsening [0.03%]
用于预防心力衰竭或阻止其恶化的普通人群胰岛素抵抗/高胰岛素血症的筛查和治疗干预措施
Serafino Fazio,Flora Affuso,Valeria Fazio et al.
Serafino Fazio et al.
Despite significant progress in the prevention and treatment of cardiovascular diseases in recent decades, they remain the leading causes of death worldwide [...].
Beyond Acute EGFR Blockade: Biological Basis and Clinical Evidence for Long-Term Nimotuzumab Therapy [0.03%]
尼莫单抗长期治疗的生物学基础及临床证据：超越急性期EGFR阻滞疗法
Tania Crombet Ramos,Arlhee Díaz Miqueli,Rolando Pérez Rodríguez
Tania Crombet Ramos
Nimotuzumab is a humanized anti-EGFR monoclonal antibody with a unique pharmacodynamic profile characterized by intermediate affinity and bivalent binding dependence, enabling density-selective tumor targeting while sparing normal tissues f...
Integrated Multiomics Reveals Gut-Brain Axis Dysregulation and Phenotype-Specific Metabolic Signatures in Children with Febrile Seizures [0.03%]
整合多组学揭示发热性惊厥儿童的肠脑轴失调及表型特异性代谢特征
Xin Zhang,Lingyan Ma,Yang Wen et al.
Xin Zhang et al.
Background: Febrile seizures (FSs) are the most common neurological emergency in early childhood; however, the biological basis of disease heterogeneity remains poorly understood. Although growing evidence suggests that gut-brain axis dysre...
Integrated Impact of Post-TAVR Cardiac Damage and Pacemaker Implantation on Long-Term Outcomes [0.03%]
经导管主动脉瓣置换术后心脏损伤和起搏器植入的综合影响对长期预后的影响
Xinyue Yang,Ruisi Tang,Yijun Yao et al.
Xinyue Yang et al.
Background/Objectives: Post-procedural permanent pacemaker implantation (PPMI) and cardiac damage are individually associated with adverse outcomes following transcatheter aortic valve replacement (TAVR). However, their joint impact has not...
The Microbiota Metabolite-Joint Axis: Mechanistic Insights and Therapeutic Targets for Osteoarthritis [0.03%]
微生物代谢物-关节轴：骨关节炎的机制见解和治疗靶点
Gaoyu Song,Junwen Jing,Ziliang Su et al.
Gaoyu Song et al.
Background: Osteoarthritis (OA) is the most common degenerative joint disease globally, with its pathogenesis yet to be fully elucidated. Accumulating evidence has redefined OA as a systemic low-grade inflammatory disorder. While the gut mi...
Manual and Fully Automated Chemotaxis-Based Cancer Screening Yield Equivalent Performance: A Nine-Month Real-World, Side-by-Side Study of the N-NOSE Workflow [0.03%]
手动和全自动趋化性癌症筛查效果相当：N-NOSE工作流程的九个月平行真实世界研究
Hideyuki Hatakeyama,Masayo Morishita,Hirotaka Oshida et al.
Hideyuki Hatakeyama et al.
Background/Objectives: The N-NOSE test is a non-invasive, urine-based multi-cancer screening assay that uses Caenorhabditis elegans chemotaxis toward cancer-associated volatile organic compounds in human urine. Scaling the test from a manua...
Efficacy of Expressed Breast Milk Versus Sweet Solutions for Neonatal Procedural Pain: A Systematic Review and Meta-Analysis [0.03%]
母乳与甜溶液缓解新生儿疼痛效果的系统评价和 meta 分析
Vanessa Espejo-Mansilla,Alessandra Coscia,Héctor Fuentes-Barría et al.
Vanessa Espejo-Mansilla et al.
Objective: To evaluate the efficacy of expressed breast milk in reducing procedural pain in neonates compared with sweet solutions and to assess differences according to type of sweetener and timing of pain assessment. Materials and Methods...