Integrated Multi-Omics Identifies Core Molecular Targets in Cerebral Venous Sinus Thrombosis-Induced Brain Injury [0.03%]
整合多组学识别颅内静脉窦血栓引起的脑损伤核心分子靶点
Xiaohong Qin,Haoran Lu,Zhibiao Chen et al.
Xiaohong Qin et al.
Background: Cerebral venous sinus thrombosis (CVST) is a critical cause of brain injury and intracranial hypertension. However, its underlying molecular mechanisms remain poorly understood, limiting the development of targeted therapies. Th...
PRF-Modified Graft Materials in Lateral Sinus Augmentation: A Systematic Review of Histologic Outcome [0.03%]
侧向窦提升术中修改的移植物材料的系统评价：组织学结果评估
Guy Kukis,Gabriele Birbalaite,Audra Janovskiene et al.
Guy Kukis et al.
Background: Platelet-rich fibrin (PRF) has been increasingly investigated as a biological adjunct in maxillary sinus augmentation procedures because of its potential to enhance bone regeneration and graft remodelling. However, the histologi...
Pre-Treatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Biomarkers for Sentinel Lymph Node Positivity and Recurrence-Free Survival in Primary Cutaneous Melanoma: An Exploratory Single-Centre Retrospective Cohort Study [0.03%]
初步探讨中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率作为原发皮肤黑色素瘤患者哨点淋巴结阳性及无复发生存期预后生物标志物的价值：一项单中心回顾队列研究
Roxana Grigore,Roxana Manuela Fericean,Mihail-Alexandru Badea et al.
Roxana Grigore et al.
Background and Objectives: Systemic inflammation contributes to melanoma progression, yet the prognostic value of routinely available inflammatory ratios remains insufficiently characterized in real-world cohorts. We evaluated whether pre-t...
Jenny Valentina Garmendia,Humberto Azpurua,Alexis Hipólito García et al.
Jenny Valentina Garmendia et al.
Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by target organ damage, affecting approximately 5% of pregnancies. Complex neuroendocrine alterations, vascular imbalances, excessive oxidative stress, environmental fa...
Baseline Biomarkers Associated with Early Anatomical Response After Faricimab Loading Therapy in Treatment-Naïve Neovascular Age-Related Macular Degeneration [0.03%]
法罗昔单抗负荷治疗性未接受过治疗的湿性年龄相关性黄斑变性的早期解剖学反应相关的基线生物标志物
Eisuke Ikeuchi,Akiko Miki,Toshiki Oka et al.
Eisuke Ikeuchi et al.
Background/Objectives: We identified baseline factors associated with early anatomical response to faricimab. Methods: This single-center retrospective study included 78 treatment-naïve eyes with neovascular age-related macular degeneratio...
Guaianolide Sesquiterpene Lactones from Globe Artichoke (Cynara scolymus L.) Induce Nrf2-Associated Antioxidant Signaling [0.03%]
药用植物菊芋（Jerusalem artichoke，Cynara scolymus L.）中的倍半萜内酯通过NRF2通路诱导抗氧化信号响应
Preeti Kushwaha,Sualiha Afzal,Ritesh Raju et al.
Preeti Kushwaha et al.
Background/Objectives: Oxidative and electrophilic stress-response pathways contribute to cellular resilience across various chronic diseases, including neurodegenerative, hepatic, and metabolic disorders. Pharmacological activation of the ...
CD86 in Dendritic Cell-Mediated Cancer Immunity: From Maturation Marker to Functional Regulator [0.03%]
树突状细胞介导的癌症免疫中的CD86：从成熟标志物到功能调节因子
Ting-Wei Wu,Chu-Hsin Chuang,Yi-Hui Wu
Ting-Wei Wu
Dendritic cell (DC)-based cancer immunotherapy remains limited by heterogeneous immune responses and variable clinical efficacy. CD86, a key co-stimulatory molecule, is traditionally regarded as a marker of dendritic cell maturation; howeve...
Expression of LAG-3, TIM-3, and VISTA on Tumor-Infiltrating Lymphocytes in Advanced Laryngeal Squamous Cell Carcinoma and Their Association with CD8+ TIL Density [0.03%]
晚期喉部鳞状细胞癌肿瘤浸润淋巴细胞中LAG-3、TIM-3和VISTA的表达及其与CD8+TIL密度的关系
Erdoğan Özgür,Ayça Tan,Özlem Yersal et al.
Erdoğan Özgür et al.
Background: Alternative immune checkpoints such as lymphocyte-activation gene 3 (LAG-3), T-cell immunoglobulin and mucin-domain-containing-3 (TIM-3), and V-domain Ig suppressor of T-cell activation (VISTA) have emerged as potential modulato...
Coordinated Two-Node Blockade of NF-κB and TGF-β/Smad Signaling Attenuates the Foreign Body Response to Prevent Capsular Contracture [0.03%]
协同抑制NF-κB和TGF-β/Smad信号通路缓解宿主反应以预防包膜收缩畸形形成
Xiaofei Tong,Meina Sun,Xin Gan et al.
Xiaofei Tong et al.
Background: Capsular contracture is driven by self-amplifying foreign body response (FBR) where inflammatory and fibrotic signals from fibroblasts and macrophages reinforce each other. We hypothesized that cogradient simultaneous blockade o...
Live Visualization of Endoplasmic Reticulum Redox Potential in Zebrafish Embryos Reveals Region-Specific Heterogeneity [0.03%]
live visualization揭示斑马鱼胚胎内质网氧化还原电位的区域异质性
Monika Verma,Niraj Rajesh Bhatt,Koushika Chandrasekaran et al.
Monika Verma et al.
Objective: Redox homeostasis is an integral part of many cellular processes, and its perturbation is associated with conditions such as diabetes, aging, and neurodegenerative disorders. Redox homeostasis or redox potential in organelles is ...