Experimental and Computational Insights into the Apoptotic Potential of New Phenanthroline-Based Copper(II) Complexes: From Spectroscopic Characterization and In Vitro Cytotoxicity to In Silico Target Identification [0.03%]
新型菲啶铜（II）复合物凋亡潜力的实验和计算见解：从光谱表征和体外细胞毒性到基于计算机的目标识别
Jesús Magdiel García-Díaz,Héctor Alejandro Bacilio-Beltrán,Asbiel Felipe Garibaldi-Ríos et al.
Jesús Magdiel García-Díaz et al.
Background: Two novel copper(II) coordination complexes, PH-Cu [(1,10-phenanthroline)(malonato)copper(II)] and PC-Cu [(1,10-phenanthroline)(cyclobutane-1,1-dicarboxylato)copper(II)], were synthesized and evaluated as potential anticancer ag...
A Self-Assembling Peptide Platform for Intratumoral Doxorubicin Delivery and Preliminary Immune-Related Modulation in B16-F10 Melanoma [0.03%]
用于黑色素瘤体内阿霉素递送的肿瘤微环境响应型自组装多肽平台及其初步免疫学研究
Xufang Ying,Jingjing Peng,Zhiqing Ben et al.
Xufang Ying et al.
Background: Local drug delivery can increase antitumor exposure while limiting systemic toxicity, but chemotherapy-only local treatment may not fully control residual tumor growth in immunosuppressive tumor microenvironments. This study aim...
Intervention with Polyvalent Bacterial Lysate Modulates T Helper Cell Subsets in Polish Children with Grass Pollen-Induced Allergic Rhinitis [0.03%]
多价细菌溶胞产物干预调节波兰儿童草花粉过敏性鼻炎T辅助细胞亚群的作用研究
Kamil Janeczek,Wioleta Grzegorzewska,Michał Zarobkiewicz et al.
Kamil Janeczek et al.
Background: Allergic rhinitis (AR) is a chronic condition that affects children's quality of life. Studies show that adding bacterial lysates (BLs) to treatment can improve outcomes, but their effects on the immune system are still not full...
FIA-MS/MS-Based Targeted Metabolomics of Amino Acids and Acylcarnitines Uncovers Network-Level Metabolic Reprogramming in Chronic Kidney Disease [0.03%]
基于FIA-MS/MS的氨基酸和酰基肉碱靶向代谢组学揭示慢性肾脏疾病中的网络水平代谢重组现象
Luisa-Gabriela Bogos,Ioana-Ecaterina Pralea,Alin-Iulian Moldovan et al.
Luisa-Gabriela Bogos et al.
Background/Objectives: Chronic kidney disease (CKD) is a major global public health problem, and conventional biomarkers such as serum creatinine primarily reflect excretory function with limited sensitivity for early detection and for pred...
Early Post-Treatment Eosinophil Elevation and Survival Outcomes in Metastatic Renal Cell Carcinoma Treated with First-Line VEGFR-TKI Monotherapy: A Turkish Multicenter Retrospective Cohort Study [0.03%]
一线VEGFR-TKI单药治疗转移性肾细胞癌的早期疗效及生存预后：一项土耳其多中心回顾队列研究
Oktay Halit Aktepe,Shamil Rustamov,Rezan Berkay Izgor et al.
Oktay Halit Aktepe et al.
Background/Objectives: We aimed to evaluate the association between early post-treatment eosinophil (Eo) elevation and survival outcomes in metastatic renal cell carcinoma (mRCC) treated with vascular endothelial growth factor receptor tyro...
Chronic Δ9-Tetrahydrocannabinol Inhalation Following Osteoporosis Results in Bone Deficits [0.03%]
慢性Δ9-四氢大麻酚吸入导致骨质疏松后的骨质缺陷
Aidan Powell,Grace Clouse,Samantha L Penman et al.
Aidan Powell et al.
Background: Osteoporosis, a debilitating bone disease characterized by low bone mineral density, poses a large burden on the population. Current pharmacological treatment options are limited, with antiresorptive drugs being the current firs...
Comparison of Nerve Growth Factor with Fetal Bovine Serum for Promoting Closure of Defects in Corneal Epithelial Cell Layers [0.03%]
nerve growth factor与胎儿牛血清促进角膜上皮层缺陷愈合的比较研究
Michael R Kozlowski
Michael R Kozlowski
Background: Disruption of the corneal epithelial (CE) cell layer is a pathological feature of several ocular disorders including the potentially severe condition, neurotrophic keratitis (NK). The drug, Oxervate™, whose active principle is ...
AdipoRon Modulation of the Invasive Potential of Prostate Cancer Cells Is Dependent on Their EMT-Related Phenotype [0.03%]
前列腺癌细胞的侵袭性与EMT表型相关状态有关取决于AdipoRon的调节
Ana Luiza Romano Gabriel,Francesca Bianchi,Michele Sommariva et al.
Ana Luiza Romano Gabriel et al.
Background/Objectives: The epithelial-to-mesenchymal transition (EMT) process provides cancer cells with morpho-functional characteristics for invasion and metastasis. A reduction in serum adiponectin (APN) has been detected in prostate can...
Mechanistic Interplay Between Multiple Myeloma and Severe SARS-CoV-2 Infection: Therapeutic Promise of Mesenchymal Stem Cell-Derived Extracellular Vesicles [0.03%]
多发性骨髓瘤与严重SARS-CoV-2感染之间的机制相互作用：间充质干细胞衍生的细胞外囊泡的治疗前景
Yan Leyfman,Niharika Ikkurthy,Taha Kassim Dohadwala et al.
Yan Leyfman et al.
Patients with multiple myeloma (MM) exhibit profound immune dysregulation, predisposing them to severe outcomes following SARS-CoV-2 infection. Current evidence highlights shared immunopathological mechanisms linking MM and COVID-19, with p...
Uncertainty-Aware Prediction Across Endoscopic Domains: Laryngeal Narrow-Band and Gastrointestinal Imaging [0.03%]
基于不确定性的内窥镜窄带和胃肠影像跨域预测方法研究
Behnam Kiani Kalejahi,Sajid Khan,Murodbek Akhrorov et al.
Behnam Kiani Kalejahi et al.
Background: Deep-learning systems for endoscopic image classification are commonly evaluated with random data splits, which may overestimate performance under acquisition shift; uncertainty-aware selective prediction may improve reliability...