A Predictive Immunological Signature Associated with Pathological Response in Breast Cancer Treated with Neoadjuvant Chemotherapy [0.03%]
新辅助化疗治疗的乳腺癌患者预后的病理反应免疫学预测标志物研究
Luis Arturo Palafox-Mariscal,Mariel García-Chagollán,Jesús García-Gómez et al.
Luis Arturo Palafox-Mariscal et al.
Background/Objectives: Breast cancer is a heterogeneous and complex disease with significant individual differences in molecular immunophenotype, biological behavior, histopathological morphology, and response to chemotherapy. The presence ...
Structural and Functional Regulation of RyR2 in Cardiac Calcium Handling and Arrhythmogenesis [0.03%]
心脏钙处理和心律失常中RyR2的结构与功能调节
Kaiyang Gao,Wenzhuo Wang,Yanan Ling et al.
Kaiyang Gao et al.
Cardiac Ca2+ handling is critical for excitation-contraction coupling (ECC), with the ryanodine receptor type 2 (RyR2) serving as the key sarcoplasmic reticulum (SR) Ca2+ release channel in cardiomyocytes. The dysfunction of RyR2 is linked ...
The Effect of Heparin-Grafted Chitosan-Cellulose Composite Microspheres on the Removal of Endotoxins and Circulating Histones in a Septic Rabbit Model: An In Vivo Study [0.03%]
硫酸肝素接枝壳聚糖-纤维素复合微球去除脓毒症兔模型内毒素和循环组蛋白的体内研究
Luojia Jiang,Ying Li,Fang Wan et al.
Luojia Jiang et al.
Background/Objectives: The strategy of targeting endotoxins and circulating histones to alleviate excessive inflammation and tissue damage has been proposed as an important immunoregulatory strategy against sepsis. However, the development ...
Linjia Hu,Haimin Lu,Yufan Shen et al.
Linjia Hu et al.
Satellite glial cells (SGCs) are morphologically unique peripheral glial cells that surround neuronal somas in sensory, sympathetic, and parasympathetic ganglia. Satellite glial cells communicate with neurons that they ensheathe and form a ...
Circulating miR-99a-5p and miR-1246 as Diagnostic and Stage-Associated Biomarkers in Laryngeal Squamous Cell Carcinoma [0.03%]
喉部鳞状细胞癌的循环miR-99a-5p和miR-1246诊断及分期标志物价值研究
Alexandru-Romulus Hut,Gheorghe Iovanescu,Eugen Radu Boia et al.
Alexandru-Romulus Hut et al.
Background and Objectives: Circulating microRNAs may provide minimally invasive biomarkers for laryngeal squamous cell carcinoma (LSCC), but clinically interpretable data for miR-99a-5p and miR-1246 remain limited. We compared circulating l...
Protective Antioxidant Effects of Ganoderma lucidum Against Prenatal Chlorpyrifos-Induced Developmental Nephrotoxicity in Rats [0.03%]
灵芝对氯氰菊酯致胎鼠肾毒性的抗氧化保护作用研究
Şeyma Şimşirgil Kara,Dilek Sağır
Şeyma Şimşirgil Kara
Background/Objectives: Chlorpyrifos (CPF), a widely used organophosphate pesticide, has been associated with oxidative stress-mediated renal injury. Prenatal exposure may pose a risk for developmental nephrotoxicity; however, data regarding...
Adipose-Derived Stem Cell Treatment Induces Early-Term Hes1 Upregulation in a Sox9- and Notch1-Independent Manner in a Rat Model of Bile Duct Ligation [0.03%]
脂肪源性干细胞治疗通过SOX9和NOTCH1非依赖方式诱导胆道结扎大鼠模型早期HES1上调
Basri Satılmış,Egemen Çiçek,Serdar Karakaş et al.
Basri Satılmış et al.
Background/Objectives: Bile duct ligation (BDL), characterized by marked inflammation and fibrosis, effectively mimics many clinical conditions and is a valuable tool for investigating biliary regeneration. Our objective was to clarify the ...
Mitochondrial Injury Accompanied by Intermediate Filament Remodeling Following Lithium Chloride Exposure in 3D Endometrial Cancer Spheroids [0.03%]
氯化锂暴露对三维子宫内膜肿瘤球体线粒体损伤及中间丝重建的影响
Berna Yıldırım,Burcu Biltekin,Mete Hakan Karalök et al.
Berna Yıldırım et al.
Background/Objectives: Endometrial cancer frequently develops resistance to therapy, partly due to the ability of tumor cells to adapt to cellular stress through non-apoptotic mechanisms. Mitochondrial dysfunction and cytoskeletal remodelin...
The Time-Dependent Effects of Temozolomide on Autophagy Gene Expression in Glioblastoma Cells [0.03%]
替莫唑胺对胶质母细胞瘤细胞自噬基因表达时间依赖性影响的体外研究
İlker Kiraz,Veli Kaan Aydın,Özgür Kurt et al.
İlker Kiraz et al.
Background: Temozolomide (TMZ) resistance represents a major therapeutic challenge in glioblastoma treatment, where autophagy has emerged as a key adaptive survival mechanism. Although numerous studies have implicated autophagy in TMZ resis...
Targeting T-Cells for Cancer Treatment: Current Clinical Strategies and Challenges [0.03%]
T细胞癌症治疗靶向：临床策略与挑战
Anand Rotte,Mentor Sopjani,Madhuri Bhandaru
Anand Rotte
Modulation of immune response to target tumor cells has been shown to be a successful strategy for cancer treatment. Over the past years immunotherapy has been integrated into cancer treatment and PD-1 blockers have become the backbone of t...