The Poly-Arginine Peptide R18D Inhibits Amyloid-Beta (Aβ) Aggregation and Aβ-Induced Cytotoxicity, Reduces Intracellular Tau Aggregation, and Exhibits Oral Bioavailability [0.03%]
Poly-精氨酸肽R18D抑制淀粉样蛋白-β(Aβ)聚集和由Aβ诱导的细胞毒性，减少tau蛋白聚集并具有口服生物利用度
Vaishali Bagda,Zainab H Farooz,Neville W Knuckey et al.
Vaishali Bagda et al.
Background/Objectives: Effective disease-modifying therapies targeting pathogenic proteins associated with Alzheimer's disease (AD) remain limited. This study investigated the therapeutic potential of the neuroprotective, cationic arginine-...
Machine Learning-Based Prediction of Treatment Response to Vitamin D3 in Adolescents and Young Adults with Inflammatory Bowel Disease: A Prospective, Open-Label, Alternation-Based Comparative Study [0.03%]
基于机器学习预测维生素D3治疗青少年和年轻人炎症性肠病的疗效：一项前瞻性、开放标签、交替比较研究
Marina Adriana Mercioni,Adrian Goldiș,Nina Holban et al.
Marina Adriana Mercioni et al.
Background: Chronic inflammatory bowel diseases (IBDs), specifically Crohn's disease and ulcerative colitis, present substantial clinical challenges characterized by a relapsing-remitting course. These conditions often lead to serious compl...
Nikhil Bhimsing Khandale,Jitendra Gour,Iqubal Singh et al.
Nikhil Bhimsing Khandale et al.
The clinical success of cisplatin has significantly spurred the exploration of new organometallic complexes in oncology. In this quest, repurposing of auranofin as an anticancer agent has diverted the research interest from platinum to gold...
Liver Dysfunction Explains a Substantial Proportion of Circulating cfDNA Variability in HCC: An Exploratory Study [0.03%]
肝功能异常解释了肝癌患者循环肿瘤DNA变异性的相当一部分因素：一项探索性研究
Ioana Manea,Speranta Maria Iacob,Razvan Iacob et al.
Ioana Manea et al.
Introduction: Circulating cell-free DNA (cfDNA) has emerged as a promising minimally invasive biomarker in hepatocellular carcinoma (HCC), with potential applications in disease detection and prognostic stratification. This exploratory stud...
Association of Endometrial HAND2 Expression with β2-Glycoprotein I Antibodies in Recurrent Pregnancy Loss [0.03%]
子宫内膜HAND2表达与复发性流产患者抗β2糖蛋白I抗体的相关性研究
Madina Khalmirzaeva,Gulzhakhan Omarova,Almagul Kurmanova et al.
Madina Khalmirzaeva et al.
Background: Recurrent pregnancy loss (RPL) is frequently linked to antiphospholipid antibodies, yet many affected women are seronegative for the classical (Sydney) criteria antibodies. In a previously characterized cohort, an extended antip...
Michela Buttà,Arianna Sucato,Giuseppina Capra
Michela Buttà
In recent years, the growing interest in microbiota, supported by increasing evidence from next-generation sequencing (NGS)-based studies, has led to the hypothesis that multifactorial conditions such as male infertility may have their base...
Dynamic Complement Activation Predicts 12-Month Major Adverse Cardiovascular Events in Acute Coronary Syndromes [0.03%]
动态补体激活可预测急性冠脉综合征患者发病12个月内的主要不良心血管事件
Florin-Leontin Lazar,Paula Anderco,Teodor Paul Kacso et al.
Florin-Leontin Lazar et al.
Background: The role of complement activation in acute coronary syndromes (ACS) and its prognostic significance after percutaneous coronary intervention (PCI) remain incompletely understood. Methods: In this prospective single-center study,...
Altered Stool Cytokine Profiles and Pro-Inflammatory/Anti-Inflammatory Imbalance in Children with Autism Spectrum Disorder: A Developmental Analysis [0.03%]
儿童自闭症谱系障碍肠道菌群细胞因子特征改变及促炎与抗炎失衡的发育分析
Petra Finderle,Maja Jekovec Vrhovšek,Uršula Prosenc Zmrzljak et al.
Petra Finderle et al.
Background: Immune dysregulation and gut dysbiosis are increasingly implicated in autism spectrum disorder (ASD), but compartment-specific intestinal cytokine profiles remain poorly defined. Aim: To characterize stool cytokine profiles and ...
Navigating the Therapeutic Landscape of Multiple Myeloma: Immunotherapy, Microenvironment, and Resistance [0.03%]
多重骨髓瘤的治疗 landscape：免疫疗法、微环境和耐药性
Sreejeta Mondal,Nathan Becker,Yang Huo et al.
Sreejeta Mondal et al.
Immunotherapies, including chimeric antigen receptor (CAR) T cells, bispecific T-cell engagers (BiTEs), and antibody-drug conjugates (ADCs), have revolutionized the treatment landscape for multiple myeloma (MM). Despite robust initial respo...
Evaluation of ChatGPT-5 for CT Imaging in Canadian CT Head Rule-Positive Mild Traumatic Brain Injury: A Pilot Study [0.03%]
评估ChatGPT-5在加拿大CT头部规则阳性轻度脑外伤中的CT影像应用：一项初步研究
Marios Lampros,Eleni Romeo,Panagiota Zagorianakou et al.
Marios Lampros et al.
Background and Objectives: Mild traumatic brain injury (mTBI) is a common cause of emergency department visits worldwide. Optimal decisions are essential for optimizing patient outcomes while minimizing unnecessary imaging. The present stud...