Identifying Endogenous Proteins of Perennial Ryegrass (Lolium perenne) with Ex Vivo Antioxidant Activity [0.03%]
具有体外抗氧化活性的多年生黑麦草(Lolium perenne)内源性蛋白的鉴定
Kathrine Danner Aakjær Pedersen,Line Thopholm Andersen,Mads Heiselberg et al.
Kathrine Danner Aakjær Pedersen et al.
Background: During the initial steps of green biorefining aimed at protein recovery, endogenous proteins and enzymes, along with, e.g., phytochemical constituents, are decompartmentalized into a green juice. This creates a highly dynamic en...
Differential Signaling Pathways Identified in Aqueous Humor, Anterior Capsule, and Crystalline Lens of Age-Related, Diabetic, and Post-Vitrectomy Cataract [0.03%]
年龄相关性，糖尿病性和玻璃体切割术后白内障晶状体液，囊膜和晶状体中鉴定出不同的信号通路
Christina Karakosta,Martina Samiotaki,Anastasios Bisoukis et al.
Christina Karakosta et al.
Background: The purpose of this study was to detect proteomic alterations and corresponding signaling pathways involved in the formation of age-related cataract (ARC), diabetic cataract (DC), and post-vitrectomy cataract (PVC). Methods: Thr...
DNA Damage-Induced Ferroptosis: A Boolean Model Regulating p53 and Non-Coding RNAs in Drug Resistance [0.03%]
药物耐药性介导的DNA损伤诱导铁死亡调控p53和非编码RNA的布尔模型
Shantanu Gupta,Daner A Silveira,José Carlos M Mombach et al.
Shantanu Gupta et al.
The tumor suppressor p53, in its wild-type form, plays a central role in cellular homeostasis by regulating senescence, apoptosis, and autophagy within the DNA damage response (DDR). Recent findings suggest that wild-type p53 also governs f...
Michele Costanzo,Marianna Caterino,Lucia Santorelli
Michele Costanzo
The rapid and substantial advancements in proteomic and metabolomic technologies have revolutionized our ability to investigate biological systems [...].
Identification of Proteoforms Related to Nelumbo nucifera Flower Petaloid Through Proteogenomic Strategy [0.03%]
基于蛋白质组学策略的荷花瓣形花萼蛋白定性分析
Zhongyuan Lin,Jiantao Shu,Yu Qin et al.
Zhongyuan Lin et al.
Nelumbo nucifera is an aquatic plant with a high ornamental value due to its flower. Despite the release of several versions of the lotus genome, its annotation remains inefficient, which makes it difficult to obtain a more comprehensive kn...
Novel Integration of Spatial and Single-Cell Omics Data Sets Enables Deeper Insights into IPF Pathogenesis [0.03%]
新型的空间和单细胞组学数据集的整合能够更深入地洞察IPF发病机制
Fei Wang,Liang Jin,Xue Wang et al.
Fei Wang et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by repetitive alveolar injuries with excessive deposition of extracellular matrix (ECM) proteins. A crucial need in understanding IPF pathogenesis is identifyin...
HRAMS Proteomics Insights on the Anti-Filarial Effect of Ocimum sanctum: Implications in Phytochemical-Based Drug-Targeting and Designing [0.03%]
圣罗勒抗丝虫作用的HRAMS蛋白组学分析：植物化学药物靶向和设计的意义
Ayushi Mishra,Vipin Kumar,Sunil Kumar et al.
Ayushi Mishra et al.
Lymphatic filariasis (LF) continues to impact 657 million individuals worldwide, resulting in lifelong and chronic impairment. The prevalent anti-filarial medications-DEC, albendazole, and ivermectin-exhibit limited adulticidal efficacy. De...
Phospho-Proteomics Analysis of Early Response to X-Ray Irradiation Reveals Molecular Mechanism Potentially Related to U251 Cell Radioresistance [0.03%]
基于U251细胞的质谱磷酸化蛋白质组学研究及其放射抗拒相关分子机制分析
Ousseynou Ben Diouf,Antoine Gilbert,Benoit Bernay et al.
Ousseynou Ben Diouf et al.
Glioblastoma (GBM) is a devastating malignant brain tumor with a poor prognosis. GBM is associated with radioresistance. Post-translational modifications (PTMs) such as protein phosphorylation can play an important role in the cellular resp...
Affinity-Enriched Plasma Proteomics for Biomarker Discovery in Abdominal Aortic Aneurysms [0.03%]
基于亲和富集的血浆蛋白质组学在腹主动脉瘤生物标志物发现中的应用研究
Nicolai Bjødstrup Palstrøm,Kristian Boje Nielsen,Amanda Jessica Campbell et al.
Nicolai Bjødstrup Palstrøm et al.
Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by the weakening and dilation of the abdominal aorta. Few diagnostic biomarkers have been proposed for this condition. We performed mass spectrometry-based proteo...
Deep Proteome Coverage of Microglia Using a Streamlined Data-Independent Acquisition-Based Proteomic Workflow: Method Consideration for a Phenotypically Diverse Cell Type [0.03%]
一种简化的数据非依赖型采集质谱工作流程对小胶质细胞进行了深入的蛋白质组覆盖：针对表型多样性的细胞类型的方法考虑因素
Jessica Wohlfahrt,Jennifer Guergues,Stanley M Stevens Jr
Jessica Wohlfahrt
As the primary innate immune cells of the brain, microglia play a key role in various homeostatic and disease-related processes. To carry out their numerous functions, microglia adopt a wide range of phenotypic states. The proteomic landsca...