Beyond Repression: ArsR Functions as a Global Activator of Metabolic and Redox Responses in Escherichia coli [0.03%]
超越抑制作用：ArsR通过激活大肠杆菌中代谢和氧化还原反应发挥全局调节功能
Brett Sather,James Larson,Kian Hutt Vater et al.
Brett Sather et al.
Background: The arsenic-responsive repressor, ArsR, has long been understood as a canonical regulator of the arsRBC operon, which confers resistance to arsenic stress. However, recent studies suggest a broader regulatory ...
Proteomics and Bioinformatics Profiles of Human Mesothelial Cell Line MeT-5A [0.03%]
人腹膜间皮细胞系MeT-5A的蛋白质组和生物信息学特征分析
Rachel L Watkin,Avedis A Kazanjian,Jennifer R Damicis et al.
Rachel L Watkin et al.
Background: Despite existing proteomics studies of other cell types, a comprehensive proteome of mesothelial cells has not been characterized. This study establishes a crucial baseline proteome for mesothelial cells to better understand the...
The Proteome of Dictyostelium discoideum Across Its Entire Life Cycle Reveals Sharp Transitions Between Developmental Stages [0.03%]
dictyostelium discoideum生命周期全程蛋白组揭示其发育阶段间的剧烈转变
Sarena Banu,P V Anusha,Pedro Beltran-Alvarez et al.
Sarena Banu et al.
Background: Dictyostelium discoideum is widely used in developmental and evolutionary biology due to its ability to transition from a single cell to a multicellular organism in response to starvation. While transcriptome ...
Andrew Hesketh,Juned Kadiwala,Vaishnavi Ravikumar et al.
Andrew Hesketh et al.
Background: Insect metamorphosis is one of the most fascinating developmental processes in the natural world. Complete metamorphosis requires the breakdown and reorganisation of larval tissues and the coordinated construc...
Comprehensive Insights into Obesity and Type 2 Diabetes from Protein Network, Canonical Pathway, Phosphorylation and Antimicrobial Peptide Signatures of Human Serum [0.03%]
人类血清蛋白网络、经典途径、磷酸化和抗菌肽谱型对肥胖与2型糖尿病的全面解析
Petra Magdolna Bertalan,Erdenetsetseg Nokhoijav,Ádám Pap et al.
Petra Magdolna Bertalan et al.
Background: Obesity is a major risk factor for type 2 diabetes (T2D); however, the molecular links between these conditions are not fully understood. Meth...
Proteome Profiling of Rabies-Infected and Uninfected Dog Brain Tissues, Cerebrospinal Fluids and Serum Samples [0.03%]
狂犬病感染与未感染犬脑组织、脑脊液及血液样品的蛋白质组学研究
Ukamaka U Eze,Rethabile Mokoena,Kenneth I Ogbu et al.
Ukamaka U Eze et al.
Background: Rabies is among the oldest known zoonotic viral diseases and is caused by members of the Lyssavirus genus. The prototype species, Lyssavirus rabies, effectively evades the host immune response, allowing the in...
Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic Biomarkers [0.03%]
非肌层浸润性膀胱癌的蛋白质组特征分析揭示了分期特异性分子标志物和预后生物标志物
Lorenza Vantaggiato,Marco Frisenda,Enxhi Shaba et al.
Lorenza Vantaggiato et al.
Background: Non-muscle invasive bladder cancer (NMIBC) comprises high-grade (HG) and low-grade (LG) variants, classified by aggressiveness, recurrence risk, and stage-either non-invasive (pTa) or invading the lamina propria (pT1). Cystoscop...
Fotios P Galanis,Avgi E Apostolakou,Georgia I Nasi et al.
Fotios P Galanis et al.
Background: Amyloidogenic proteins, a heterogenous group of proteins characterized by their ability to form amyloid fibrils, lead to pathological conditions when they undergo abnormal folding and self-assembly. Missense single-nucleotide po...
Azidohomoalanine (AHA) Metabolic Labeling Reveals Unique Proteomic Insights into Protein Synthesis and Degradation in Response to Bortezomib Treatment [0.03%]
乙基叠氮化 homoalanine (AHA) 代谢标记揭示了蛋白酶体抑制剂硼替佐米处理后蛋白质合成和降解的特异蛋白质组学信息
Lina Alhourani,Yasser Tabana,Ashwin Anand et al.
Lina Alhourani et al.
Background: Multiple myeloma (MM) is essentially an incurable cancer, but treatments with proteasome inhibitors are widely used clinically to extend patient survival. While the mechanisms of proteasome inhibition by Borte...
Comparative Proteomic Analysis of Aqueous Humor, Anterior Lens Capsules, and Crystalline Lenses in Different Human Cataract Subtypes Versus Healthy Controls [0.03%]
不同类型人眼白内障房水、前囊和晶状体蛋白组学分析
Christina Karakosta,Martina Samiotaki,Anastasios Bisoukis et al.
Christina Karakosta et al.
Background: The aim of this study is to investigate the pathophysiology of cataract by analyzing signaling pathways in three sample types obtained from four different lens groups: age-related (ARC), diabetic (DC), post-vi...