Analysis of p53-Independent Functions of the Mdm2-MdmX Complex Using Data-Independent Acquisition-Based Profiling [0.03%]
基于数据非依赖性采集的蛋白质组分析p53独立功能的Mdm2-MdmX复合体
Anu Jain,Rafaela Muniz de Queiroz,Jayanta K Chakrabarty et al.
Anu Jain et al.
Background: We utilized data-independent acquisition (DIA) to study the poorly understood biology of Mdm2 and MdmX in a p53-null context. Mdm2 and MdmX form an E3-ligase complex that has as its most well-studied function ...
Integrative Spatial Proteomics and Single-Cell RNA Sequencing Unveil Molecular Complexity in Rheumatoid Arthritis for Novel Therapeutic Targeting [0.03%]
整合型空间蛋白质组学和单细胞RNA测序揭示类风湿关节炎的分子复杂性以发掘新的治疗靶点
Xue Wang,Fei Wang,Archana S Iyer et al.
Xue Wang et al.
Understanding the heterogeneity of Rheumatoid Arthritis (RA) and identifying therapeutic targets remain challenging using traditional bulk transcriptomics alone, as it lacks the spatial and protein-level resolution needed to fully capture d...
Intrinsic Disorder and Phase Separation Coordinate Exocytosis, Motility, and Chromatin Remodeling in the Human Acrosomal Proteome [0.03%]
人类顶体蛋白组中的内在无序和相分离协调出胞、运动和染色质重塑作用
Shivam Shukla,Sean S Lastorka,Vladimir N Uversky
Shivam Shukla
Intrinsic disorder refers to protein regions that lack a fixed three-dimensional structure under physiological conditions, enabling conformational plasticity. This flexibility allows for diverse functions, including transient interactions, ...
Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis [0.03%]
肺癌腺癌和鳞状细胞癌来源的小细胞外囊泡（sEV）的摄取可改变T细胞细胞因子表达并调节sEV生物发生蛋白谱型
Hafiza Padinharayil,Jinsu Varghese,Pulikkottil Raphael Varghese et al.
Hafiza Padinharayil et al.
Background: Despite advances in immunotherapy, non-small-cell lung carcinoma (NSCLC)'s clinical success is limited, possibly due to substantial immunological alterations in advanced cancer patients. This study examines th...
Role of LIN28B in the Regulation of Ribosomal Biogenesis and Lipid Metabolism in Medulloblastoma Brain Cancer Cells [0.03%]
LIN28B在小脑星形细胞瘤脑癌细胞中的核糖体生物发生和脂质代谢调节中的作用
Ahmed Maklad,Mohammed Sedeeq,Kaveh Baghaei et al.
Ahmed Maklad et al.
Background: Medulloblastoma (MB) is the most aggressive paediatric brain cancer, highlighting the urgent need for new diagnostic and prognostic biomarkers and improved treatments to enhance patient outcomes. Our previous study identified LI...
Cell-Type-Specific Heat-Induced Changes in the Proteomes of Pollen Mother Cells and Microspores Provide New Insights into Tomato Pollen Production Under Elevated Temperature [0.03%]
高温下番茄花粉生产的细胞类型特异性热诱导蛋白组变化提供了新的见解
Priya Thapa,Jun Guo,Kajol Pradhan et al.
Priya Thapa et al.
Background: Tomatoes are self-pollinating plants, and successful fruit set depends on the production of functional pollen within the same flower. Our previous studies have shown that the 'Black Vernissage' tomato variety ...
Proteomics of Extracellular Vesicles: Recent Updates, Challenges and Limitations [0.03%]
胞外囊泡的蛋白质组学：近期更新、挑战和局限性
Mohini Singh,Prashant Kumar Tiwari,Vivek Kashyap et al.
Mohini Singh et al.
Extracellular vesicles (EVs) are lipid-bound vesicles secreted by cells, including exosomes, microvesicles, and apoptotic bodies. Proteomic analyses of EVs, particularly in relation to cancer, reveal specific biomarkers crucial for diagnosi...
Proteomic Comparison of Acute Myeloid Leukemia Cells and Normal CD34+ Bone Marrow Cells: Studies of Leukemia Cell Differentiation and Regulation of Iron Metabolism/Ferroptosis [0.03%]
急性髓系白血病细胞和正常CD34+骨髓细胞的蛋白质组学比较：白血病细胞分化及铁代谢/ ferroptosis调节的研究
Frode Selheim,Elise Aasebø,Håkon Reikvam et al.
Frode Selheim et al.
Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy that can be cured only by intensive chemotherapy possibly combined with allogeneic stem cell transplantation. We compared the pretreatment proteomic profiles of AML cells ...
Structure-Based Deep Learning Framework for Modeling Human-Gut Bacterial Protein Interactions [0.03%]
基于结构的深度学习框架模拟人类肠道细菌蛋白质相互作用
Despoina P Kiouri,Georgios C Batsis,Christos T Chasapis
Despoina P Kiouri
Background: The interaction network between the human host proteins and the proteins of the gut bacteria is essential for the establishment of human health, and its dysregulation directly contributes to disease development. Despite its grea...
Systems Biology of Recombinant 2G12 and 353/11 mAb Production in CHO-K1 Cell Lines at Phosphoproteome Level [0.03%]
CHO-K1细胞系在磷酸蛋白质组学水平上重组生产2G12和353/11单克隆抗体的系统生物学研究
Eldi Sulaj,Felix L Sandell,Linda Schwaigerlehner et al.
Eldi Sulaj et al.
Background: Chinese hamster ovary (CHO) cells are extensively used in the pharmaceutical industry for producing complex proteins, primarily because of their ability to perform human-like post-translational modifications. However, the effici...