Evaluating Protein Extraction Techniques for Elucidating Proteomic Changes in Yeast Deletion Strains [0.03%]
评估蛋白质提取技术以阐明酵母基因敲除菌株的蛋白组变化
Valentina Rossio,Joao A Paulo
Valentina Rossio
Background: Alterations in protein abundance profiles in yeast deletion strains are frequently utilized to gain insights into cellular functions and regulatory networks, most of which are conserved in higher eukaryotes. ...
Proteoform Patterns in Hepatocellular Carcinoma Tissues: Aspects of Oncomarkers [0.03%]
肝细胞癌组织中的蛋白质形式模式：肿瘤标志物的方面
Elena Zorina,Natalia Ronzhina,Olga Legina et al.
Elena Zorina et al.
Background: Human proteins exist in numerous modifications-proteoforms-which are promising targets for biomarker studies. In this study, we aimed to generate comparative proteomics data, including proteoform patterns, fro...
Next-Generation Protein-Ligand Interaction Networks: APEX as a Powerful Technology [0.03%]
下一代蛋白质-配体相互作用网络：APEX技术的广泛应用
José Miguel Quintero-Ferrer,Lucas Silva de Oliveira,Paula Marian Vieira Goulart et al.
José Miguel Quintero-Ferrer et al.
Peroxidases are essential enzymes that catalyze redox reactions, with wide-ranging biological implications. Among these, an enhanced ascorbate peroxidase (APEX) has emerged as a valuable tool for studying intricate intracellular events with...
Davide Perico,Pierluigi Mauri
Davide Perico
Radiotherapy resistance represents a critical aspect of cancer treatment, and molecular characterization is needed to explore the pathways and mechanisms involved. DNA repair, hypoxia, metabolic reprogramming, apoptosis, tumor microenvironm...
Advances in the Study of Protein Deamidation: Unveiling Its Influence on Aging, Disease Progression, Forensics and Therapeutic Efficacy [0.03%]
蛋白质脱氨研究进展：揭示其对衰老、疾病发展、法医及疗效的影响
Sunil S Adav
Sunil S Adav
Protein deamidation, a nonenzymatic post-translational modification that converts asparagine and glutamine residues into their acidic forms, such as aspartic acid, iso-aspartic acid, or glutamic acid, has emerged as a pivotal process affect...
A Clinical Validation of a Diagnostic Test for Esophageal Adenocarcinoma Based on a Novel Serum Glycoprotein Biomarker Panel: PromarkerEso [0.03%]
基于新型血清糖蛋白生物标志物谱的诊断测试的临床验证：PromarkerEso用于食管腺癌检测
Jordana Sheahan,Iris Wang,Peter Galettis et al.
Jordana Sheahan et al.
Background: Esophageal adenocarcinoma (EAC) diagnosis involves invasive and expensive endoscopy with biopsy, but rising EAC incidence has not been reduced by increased surveillance. This study aimed to develop and clinica...
Chromosome X Open Reading Frame 38 (CXorf38) Is a Tumor Suppressor and Potential Prognostic Biomarker in Lung Adenocarcinoma: The First Characterization [0.03%]
染色体X开放阅读框38（CXorf38）是肺腺癌中的一个肿瘤抑制因子及潜在预后生物标志物：首次表征
Rui Yan,Heng-Wee Tan,Na-Li Cai et al.
Rui Yan et al.
Background: Previously, we found that an uncharacterized protein CXorf38 is significantly downregulated in human ZIP8-knockout (KO) cells. Given that ZIP8 regulates essential micronutrients linked to diseases including cancer, this study ai...
Oxidative Stress and Its Role in the Emergence and Progression of Myelodysplastic Syndromes: Insights from Proteomic Analysis and Other Methodologies [0.03%]
氧化应激及其在骨髓增生异常综合征发生和发展中的作用：来自蛋白质组学分析和其他方法的见解
Anastasia Boura-Theodorou,Konstantina Psatha,Stefania Maniatsi et al.
Anastasia Boura-Theodorou et al.
Myelodysplastic syndromes (MDS) belong to a category of malignant stem-cell and myeloid disorders that deteriorate the function of the hematopoietic system exacerbated by the omnipresent anemia that characterizes myelodysplasia. The pathoge...
Knowledge Discovery in Databases of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer [0.03%]
系统建模在胰腺癌转化研究中的蛋白质组学数据库知识发现
Mathilde Resell,Elisabeth Pimpisa Graarud,Hanne-Line Rabben et al.
Mathilde Resell et al.
Background: Knowledge discovery in databases (KDD) can contribute to translational research, also known as translational medicine, by bridging the gap between in vitro and in vivo studies, and clinical applications. Here,...
Unraveling the Central Role of Global Regulator PprI in Deinococcus radiodurans Through Label-Free Quantitative Proteomics [0.03%]
基于非标记定量蛋白质组学解析放线菌适应极端辐射损伤的转录因子PprI的作用机制
Siyu Zhu,Feng Liu,Hao Wang et al.
Siyu Zhu et al.
Background: Deinococcus radiodurans, renowned for its exceptional resistance to radiation, provides a robust model for elucidating cellular stress responses and DNA repair mechanisms. Previous studies have established Ppr...