Identification of Cancer-Associated Proteins in Colorectal Cancer Using Mass Spectrometry [0.03%]
基于质谱的结直肠癌相关蛋白识别研究
Naoyuki Toyota,Ryo Konno,Shuhei Iwata et al.
Naoyuki Toyota et al.
Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with a multifactorial etiology involving genetic and environmental factors. Advanced proteomics offers valuable insights into t...
Uncovering Enzyme-Specific Post-Translational Modifications: An Overview of Current Methods [0.03%]
揭秘酶特异性翻译后修饰：当前方法概述
Nashira H Ridgeway,Kyle K Biggar
Nashira H Ridgeway
Post-translational modifications (PTMs) govern a multitude of protein functions within the cell, surpassing the basic function(s) encoded directly within the amino acid sequence. Despite the historical discovery of PTMs dating back over a c...
Cell Surface Proteomics Reveals Hypoxia-Regulated Pathways in Cervical and Bladder Cancer [0.03%]
细胞表面组学揭示宫颈癌和膀胱癌中低氧调节的途径
Faris Alanazi,Ammar Sharif,Melissa Kidd et al.
Faris Alanazi et al.
Background Plasma membrane proteins (PMPs) play key roles in cell signalling, adhesion, and trafficking, and are attractive therapeutic targets in cancer due to their surface accessibility. However, their typically low abundance limits dete...
Multiplex Targeted Proteomic Analysis of Cytokine Ratios for ICU Mortality in Severe COVID-19 [0.03%]
重症COVID-19患者ICU死亡率的细胞因子比值的多重靶向蛋白质组分析
Rúben Araújo,Cristiana P Von Rekowski,Tiago A H Fonseca et al.
Rúben Araújo et al.
Background: Accurate and timely prediction of mortality in intensive care unit (ICU) patients, particularly those with COVID-19, remains clinically challenging due to complex immune responses. Proteomic cytokine profiling...
Molecular Remodeling of the Sperm Proteome Following Varicocele Sclero-Embolization: Implications for Semen Quality Improvement [0.03%]
精子蛋白组在精索曲张 sclero-embolization 治疗后的重组及其对改善精液质量的启示
Domenico Milardi,Edoardo Vergani,Francesca Mancini et al.
Domenico Milardi et al.
Background: Varicocele is a common condition involving the dilation of veins in the scrotum, often linked to male infertility and testicular dysfunction. This study aimed to elucidate the molecular effects of successful v...
Comprehensive Integrated Analyses of Proteins and Metabolites in Equine Seminal Plasma (Horses and Donkeys) [0.03%]
马和驴精浆蛋白和代谢物的综合分析
Xin Wen,Gerelchimeg Bou,Qianqian He et al.
Xin Wen et al.
Background: The reproductive ability of equine species is a critical component of equine breeding programs, with sperm quality serving as a primary determinant of reproductive success. In this study, we perform an integra...
Proteomic Profiling Reveals Novel Molecular Insights into Dysregulated Proteins in Established Cases of Rheumatoid Arthritis [0.03%]
蛋白质组学谱型分析揭示类风湿关节炎患者异常表达蛋白的新分子特征
Afshan Masood,Hicham Benabdelkamel,Assim A Alfadda et al.
Afshan Masood et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder that predominantly affects synovial joints, leading to inflammation, pain, and progressive joint damage. Despite therapeutic advancements, the molecular basis of establi...
Comparative Label-Based Proteomics of Venoms from Echis ocellatus, Naja nigricollis, and Bitis arietans [0.03%]
基于标签的埃奇斯·奥CELLATUS、纳贾·尼格里科利和比特IS·ARIETANS毒液蛋白质组学比较分析
Abdulbaki Alfa-Ibrahim Adio,Samuel Odo Uko,Jiddah Muhammad Lawal et al.
Abdulbaki Alfa-Ibrahim Adio et al.
Background: Snake envenomation is a major public health issue in Nigeria, primarily due to bites from Echis ocellatus, Naja nigricollis, and Bitis arietans. Understanding their venom composition is essential for effective antivenom developm...
SDS Depletion from Intact Membrane Proteins by KCl Precipitation Ahead of Mass Spectrometry Analysis [0.03%]
用于质谱分析的KCl沉淀法脱除膜蛋白完整复合物中的SDS杂质
Tania Iranpour,Mapenzi Mirimba,Chloe Shenouda et al.
Tania Iranpour et al.
Background: Membrane proteins are preferentially solubilized with sodium dodecyl sulfate (SDS), which necessitates a purification protocol to deplete the surfactant prior to mass spectrometry analysis. However, maintainin...
Alterations in Tear Proteomes of Adults with Pre-Diabetes and Type 2 Diabetes Mellitus but Without Diabetic Retinopathy [0.03%]
空腹血糖受损和/或糖耐量减退受试者及2型糖尿病患者干眼的泪液蛋白质组变化研究
Guoting Qin,Cecilia Chao,Shara Duong et al.
Guoting Qin et al.
Background: Type 2 diabetes mellitus (T2DM) is an epidemic chronic disease that affects millions of people worldwide. This study aims to explore the impact of T2DM on the tear proteome, specifically investigating whether ...