Proteomic Characterization of Primary Human Pancreatic Cancer Cell Lines Following Long-Term Exposure to Gemcitabine [0.03%]
人胰腺癌原发细胞系长期暴露于吉西他滨后的蛋白质组特征分析
Manoj Amrutkar,Yuchuan Li,Anette Vefferstad Finstadsveen et al.
Manoj Amrutkar et al.
Background: Gemcitabine (GEM) remains a cornerstone in the treatment of pancreatic cancer. Upon exposure to GEM, pancreatic cancer cells (PCCs) tend to adapt quickly to outcompete drug-induced cytotoxicity, thereby contri...
In Search of Ideal Solutions for Cancer Diagnosis: From Conventional Methods to Protein Biomarkers in Liquid Biopsy [0.03%]
从传统方法到液体活检中的蛋白质生物标志物：探寻癌症诊断的理想方案
Anca-Narcisa Neagu,Pathea S Bruno,Claudiu-Laurentiu Josan et al.
Anca-Narcisa Neagu et al.
Cancer detection has made significant progress, moving from conventional methods to innovative, non-invasive or minimally invasive approaches aimed at improving early diagnosis, precision, and treatment outcomes. This review examines curren...
Neurogranin as a Synaptic Biomarker in Mild Traumatic Brain Injury: A Systematic Review of Diagnostic and Pathophysiological Evidence [0.03%]
轻度脑创伤中的神经粒素作为突触生物标志物的诊断和病理生理证据的系统回顾
Ioannis Mavroudis,Foivos Petridis,Eleni Karantali et al.
Ioannis Mavroudis et al.
Neurogranin (NRGN), a synaptic protein essential for plasticity and memory function, is gaining recognition as a promising biomarker for mild traumatic brain injury (mTBI). This systematic review brings together findings from six studies th...
Comparative Analysis of Plasma Extracellular Vesicle Isolation Methods for Purity Assessment and Biomarker Discovery [0.03%]
用于纯度评估和生物标志物发现的血浆外泌体分离方法的比较分析
Alexandra T Star,Melissa Hewitt,Amanpreet Badhwar et al.
Alexandra T Star et al.
Background: Extracellular vesicles (EVs) are an important source of blood biomarkers and are emerging as next-generation therapeutics. Demonstrating the purity of isolated EVs is essential for applications ranging from pr...
Proteomic Analysis of Mechanical Injury Effects in Papaya Fruit at Two Maturity Stages [0.03%]
两种成熟阶段的木瓜果实机械伤后的蛋白组学分析
Francisco Antonio Reyes-Soria,Eliel Ruiz-May,Enrique Castaño et al.
Francisco Antonio Reyes-Soria et al.
Background: Mechanical damage to fruit during harvesting is nearly inevitable, with certain species, such as papaya, being particularly prone to spoilage. Postharvest handling can induce mechanical injuries that impair ri...
Endrei Marcantonio,Amy M Woron,A Christian Whelen et al.
Endrei Marcantonio et al.
Background: Patients with pulmonary tuberculosis (TB) typically produce sputa, which are used to identify the pathogen. Sputum also contains host proteins that may aid in diagnosis. We hypothesized that sputa from TB pati...
Proteomic Analysis of the Periodontal Ligament During Orthodontic Movement: A Study in Rats [0.03%]
蛋白质组学分析正畸移动期间的牙周韧带：大鼠研究
Camila Chierici Marcantonio,Maria Eduarda Scordamaia Lopes,Lélio Fernando Ferreira Soares et al.
Camila Chierici Marcantonio et al.
The periodontal ligament (PDL) is a dynamic connective tissue that absorbs and transmits mechanical forces, playing a critical role during orthodontic tooth movement (OTM). This study aimed to characterize the proteomic profile of rat PDLs ...
Bidirectional Interaction Between PGE2-Preconditioned Mesenchymal Stem Cells and Myofibroblasts Mediates Anti-Fibrotic Effects: A Proteomic Investigation into Equine Endometrial Fibrosis Reversal [0.03%]
前列腺素E2预处理间充质干细胞与肌成纤维母细胞的双向相互作用介导抗纤维化效应：马子宫内膜纤维化逆转的蛋白质组学研究
Lidice Méndez-Pérez,Yat Sen Wong,Belén O Ibáñez et al.
Lidice Méndez-Pérez et al.
Background: Endometrosis is a prevalent fibrotic condition in mares that impairs reproductive efficiency by inducing transdifferentiation of endometrial stromal cells into myofibroblasts, leading to excessive ECM depositi...
The Biological Variation in Serum ACE and CPN/CPB2 Activity in Healthy Individuals as Measured by the Degradation of Dabsylated Bradykinin-Reference Data and the Importance of Pre-Analytical Standardization [0.03%]
健康人血清ACE和CPN / CPB2活性（通过降解Dabsyl化缓激肽测定）的生物变异性的参考数据以及预分析标准化的重要性
Malte Bayer,Michael Snyder,Simone König
Malte Bayer
Background: Bradykinin (BK) is an inflammatory mediator. The degradation of labeled synthetic BK in biofluids can be used to report on the activity of angiotensin-converting enzyme (ACE) and basic carboxypeptidases N and ...
Adiposome Proteomics Uncover Molecular Signatures of Cardiometabolic Risk in Obese Individuals [0.03%]
肥胖个体中的脂质体蛋白质组学揭示心血管代谢风险的分子标志物
Mohamed Saad Rakab,Monica C Asada,Imaduddin Mirza et al.
Mohamed Saad Rakab et al.
Background: Adipose-derived extracellular vesicles (adiposomes) are emerging as key mediators of inter-organ communication, yet their molecular composition and role in obesity-related pathophysiology remain underexplored....