Comparison of the Trapping Efficiency for Tryptic Peptides on Particle-Packed and Micro-Pillar Trap Columns for Proteomics Analyses [0.03%]
用于蛋白质组分析的颗粒填充型与微柱捕集柱对胰蛋白酶肽的富集性能比较研究
Jadranka Miletić Vukajlović,Bojana Ilić,Bella Bruszel et al.
Jadranka Miletić Vukajlović et al.
Background: Low-volume trapping columns are essential for sample enrichment, desalting, and injection profile focusing on nano-LC-MS-based proteomics. They enable higher sample loading, improve chromatographic performance...
Scout-Triggered Multiple Reaction Monitoring Enables Robust Quantification of Host Cell Proteins Across Bioprocess Matrices [0.03%]
基于探针的多重反应监测可实现宿主细胞蛋白跨工艺矩阵的稳健定量
Julie Flecheux,Chloé Bardet,Laura Herment et al.
Julie Flecheux et al.
Background: Host cell proteins (HCPs) are process-related impurities that must be monitored in biopharmaceutical products due to their potential impact on product quality and patient safety. Targeted LC-MS/MS approaches s...
Proteome-Wide Analysis of Functional Phosphosites in the FGFR Family of Proteins: Insights from Large-Scale Phosphoproteomic Analysis [0.03%]
基于大规模磷酸蛋白质的研究：FGFR家族功能性磷酸化位点的蛋白质组-wide分析的新见解
Akhina Palollathil,Althaf Mahin,Athira Perunelly Gopalakrishnan et al.
Akhina Palollathil et al.
Background: Fibroblast growth factor receptors (FGFRs) play a crucial role in tissue homeostasis and organ development by regulating cellular processes, including proliferation, differentiation, and survival. Dysregulatio...
PTMs_Closed_Search: Multiple Post-Translational Modification Closed Search Using Reduced Search Space and Transferred FDR [0.03%]
基于缩小搜索空间和转移FDR的多泛素化修饰位点联合定性软件及策略
Yury Yu Strogov,Sergey A Spirin,Mark V Ivanov et al.
Yury Yu Strogov et al.
Background: Currently, post-translational modification (PTM) search in MS/MS data is performed using either open modification search (OMS) or closed search (CS) algorithms. The OMS method allows for the determination of many PTMs and unknow...
Evaluating the Impact of Two Different Diets on the Protein Profile of the Brain, Liver, and Intestine of the Barramundi [0.03%]
评估两种不同饮食对 barramundi 大脑、肝脏和肠道蛋白质谱的影响
Mohadeseh Montazeri Shatouri,Igor Pirozzi,Pinar Demir Soker et al.
Mohadeseh Montazeri Shatouri et al.
Background: Commercial feed formulations are increasingly being evaluated for their nutritional impacts on aquaculture species, yet the molecular consequences of commonly used commercial diets remain underexplored. ...
Integrated Phosphoproteomics Identifies TGFβ-Dependent Phosphorylation Events Linking Kinase Signaling to Autophagy in Palatogenesis [0.03%]
整合式磷酸蛋白质组学鉴定出TGFβ依赖性磷酸化事件将成腭过程中激酶信号与自噬联系起来
Xia Peng,Jing Chen,Xiaoyu Zheng et al.
Xia Peng et al.
Background: Cleft palate (CP) is a prevalent craniofacial malformation, with the TGFβ pathway playing a critical role. Recent evidence links autophagy to regulating mouse embryonic palatal mesenchyme (MEPM) cells, but it...
Cross-Species Analysis of ABA-Induced Phosphosignaling Landscapes in Rice, Soybean, and Arabidopsis [0.03%]
水稻、大豆和拟南芥的脱落酸诱导磷酸信号景观的跨物种分析
Hinano Takase,Sotaro Katagiri,Takuma Ide et al.
Hinano Takase et al.
Background: Abscisic acid (ABA) is a key phytohormone that regulates plant growth and stress responses through protein phosphorylation. While ABA-induced phosphosignaling has been extensively studied in Arabidopsis thalia...
Beyond Repression: ArsR Functions as a Global Activator of Metabolic and Redox Responses in Escherichia coli [0.03%]
超越抑制作用：ArsR通过激活大肠杆菌中代谢和氧化还原反应发挥全局调节功能
Brett Sather,James Larson,Kian Hutt Vater et al.
Brett Sather et al.
Background: The arsenic-responsive repressor, ArsR, has long been understood as a canonical regulator of the arsRBC operon, which confers resistance to arsenic stress. However, recent studies suggest a broader regulatory ...
Proteomics and Bioinformatics Profiles of Human Mesothelial Cell Line MeT-5A [0.03%]
人腹膜间皮细胞系MeT-5A的蛋白质组和生物信息学特征分析
Rachel L Watkin,Avedis A Kazanjian,Jennifer R Damicis et al.
Rachel L Watkin et al.
Background: Despite existing proteomics studies of other cell types, a comprehensive proteome of mesothelial cells has not been characterized. This study establishes a crucial baseline proteome for mesothelial cells to better understand the...
The Proteome of Dictyostelium discoideum Across Its Entire Life Cycle Reveals Sharp Transitions Between Developmental Stages [0.03%]
dictyostelium discoideum生命周期全程蛋白组揭示其发育阶段间的剧烈转变
Sarena Banu,P V Anusha,Pedro Beltran-Alvarez et al.
Sarena Banu et al.
Background: Dictyostelium discoideum is widely used in developmental and evolutionary biology due to its ability to transition from a single cell to a multicellular organism in response to starvation. While transcriptome ...