Pulsatilla saponin inhibits the proliferation of keratinocytes and ameliorates imiquimod-induced psoriasis through the NF-κB and STAT3 signaling pathways [0.03%]
芍药皂苷通过抑制NF-κB和STAT3信号通路缓解银屑病皮损病症及表皮细胞增殖过度的现象
Jilang Li,Haixin Qiu,Siyuan Li et al.
Jilang Li et al.
Background and aim: Pulsatilla saponin (Ps) was isolated from Pulsatilla chinensis (Bunge) Regel, a traditional Chinese medicine, that has anti-proliferation, anti-inflammation, anti-tumor and immunomodulation activities....
Electroacupuncture improves cardiac function in hyperlipidemic rats by enhancing efferocytosis in myocardial macrophages via the PPARγ-LXRα-MerTK pathway [0.03%]
电针通过PPARγ-LXRα-MerTK通路增强心肌巨噬细胞efferocytosis改善高脂血症大鼠心脏功能
Yong-Li Han,Shu-Wen Jin,Xiao-Li Pan et al.
Yong-Li Han et al.
Background and aim: Electroacupuncture (EA) is an effective treatment for hyperlipidemia because it decreases the protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor alpha (LX...
Characterizing therapeutic effects of velvet antler using different omics strategies [0.03%]
采用不同组学策略表征鹿角的治疗作用
Shang-Tse Ho,Ching-Yun Kuo,Ming-Ju Chen
Shang-Tse Ho
Velvet antler (VA) has been widely used in traditional Chinese medicine more than thousand years. Several pharmacological properties of VA have been demonstrated, such as anti-osteoporosis, anti-osteoarthritis, anti-aging, and anti-ischemia...
Integrating pharmacokinetics and network pharmacology to decipher the efficacy of Fufang Qinlan oral liquid on post infectious cough [0.03%]
基于药代动力学和网络药理学的复方芩兰口服液治疗气滞咳嗽有效成分筛选及机制研究
Leyi Huang,Yangyang Wang,Xinyi Yue et al.
Leyi Huang et al.
Background and aim: Fufang Qinlan oral liquid (QLOL) is a traditional Chinese medicine formula used to treat fevers, sore throats and cough. This study was to evaluate QLOL's therapeutic effects on post infectious cough (...
Analyzing mechanisms of qing fei bao yuan decoction granules in treating COPD based on LC-MS, network pharmacology and in vivo methods [0.03%]
基于LC-MS、网络药理学及体内实验的清肺败毒颗粒治疗慢性阻塞性肺疾病机制分析
Amei Tang,Yang Liu,Guoqiang Guan et al.
Amei Tang et al.
Background and aim: The current therapeutic interventions of chronic obstructive pulmonary disease offer only partial alleviation of symptoms, leaving the majority of patients with persistent and significant clinical mani...
Chengbin Hou,Yanzhuo Gao,Xinyu Lin et al.
Chengbin Hou et al.
Traditional Medicine (TM) has played a crucial role in global healthcare due to its long history and holistic approach. Artificial Intelligence (AI) has emerged as a revolutionary technology, offering exceptional capabilities in areas such ...
Network pharmacology approach and experimental verification of earthworm protein in the treatment of diabetes mellitus-induced erectile dysfunction [0.03%]
基于网络药理学的蚯蚓蛋白改善糖尿病所致勃起功能障碍的作用研究及实验验证
Liming Liu,Yuanfeng Zhang,Aiping Zhang et al.
Liming Liu et al.
Background: Diabetes mellitus-induced erectile dysfunction (DMED) is a common complication of diabetes mellitus. Earthworm protein (EWP) is an active protein extracted from the Chinese herbal medicine earthworm, which is ...
Himatanthus bracteatus stem bark ethanolic extract obtained by sequential pressurized liquid extraction: Chromatographic characterization and profiling of cytotoxic, antitumoral and immunopharmacological properties [0.03%]
Sequential压力流体提取获得的希马塔努斯属植物茎皮乙醇提取物的色谱特征和抗细胞毒、抗肿瘤及免疫药理性质剖析
Rose N Pereira-Filho,Wilson D Gonçalves-Júnior,Agenor G Dos Santos-Neto et al.
Rose N Pereira-Filho et al.
This study aims to characterize the cytotoxic, antitumoral and immunopharmacological profile of the ethanolic extract of Himatanthus bracteatus (EEHB) stem bark. Chromatographic analysis revealed the major EEHB composition in dimethyl isopl...
Integrated serum pharmacochemistry and network pharmacology to reveal the kernel material basis and underlying mechanisms of the fuzi-lizhong pill for ulcerative colitis [0.03%]
基于药理化学和网络药理学的附子理中丸治疗溃疡性结肠炎的物质基础及作用机制研究
You Huang,Xia Lin,Qiuhong Wu et al.
You Huang et al.
Background: In traditional Chinese medicine, Fuzi-Lizhong pill (FLZP) has been used for millennia as a treatment for the Spleen-Kidney-Yang-deficiency (SKYD) diseases. FLZP has increasingly been employed in the clinic as ...
Network pharmacology-based study to investigate the mechanism of compound houttuynia mixture against influenza virus infection by suppressing TLR7/MyD88 signaling pathway [0.03%]
基于网络药理学的穿心莲多成分通过抑制TLR7/MyD88信号通路抗流感病毒研究机制探讨
Hailin Wei,Wenlei Wang,Qin Su et al.
Hailin Wei et al.
Aim of the study: Compound houttuynia mixture (CHM) has been approved to cure respiratory diseases in China. However, the anti-influenza virus effect and underlying mechanism of CHM remains to be confirmed. ...