Cinnamaldehyde inhibits the NLRP3 inflammasome and inflammatory response by reducing oxidative stress in Neisseria gonorrhoeae-infected macrophages [0.03%]
肉桂醛通过减少氧化应激抑制淋病奈瑟菌感染的巨噬细胞中NLRP3炎性小体和炎症反应
Kuo-Feng Hua,Hsiao-Wen Chiu,Miao-Mei Chen et al.
Kuo-Feng Hua et al.
Background and aim: Gonorrhoea, a common sexually transmitted disease, is caused by Neisseria gonorrhoeae. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome regulates interleukin (IL)-1β and IL-...
Coptidis Rhizoma extract mitigates sleep deprivation-induced cognitive impairment and neurodegeneration: Insights into hormonal, glymphatic, and molecular mechanisms [0.03%]
黄连提取物缓解睡眠剥夺引起的认知障碍和神经退行性病变：对激素、胶质淋巴和分子机制的新认识
Chih-Yuan Yang,Yea-Hwey Wang,Kuo-Tong Liou et al.
Chih-Yuan Yang et al.
Background: and Aim: Coptidis Rhizoma extract (CRE) is a traditional herbal medicine commonly used to treat insomnia and cognitive deficits. However, its protective effects and underlying molecular mechanisms in condition...
Tiaojing Cuyun Recipe inhibits ferroptosis through SLC7A11/GSH/GPX4 axis to improve endometrial receptivity of mice with embryo implantation dysfunction [0.03%]
调经促孕丸通过SLC7A11/GSH/GPX4轴抑制铁死亡以改善胚植功能障碍小鼠子宫内膜容受性研究
Hui Xue,Si-Qing Huang,Yan-Qiu Xia et al.
Hui Xue et al.
Background and aim: Tiaojing Cuyun Recipe (TJCYR), a known Chinese herbal compound, has been shown to improve endometrial receptivity and embryo implantation in patients with embryo implantation dysfunction (EID). This st...
Kaixuan Qibi granules attenuate myocardial fibrosis through BRD4 blockade regulated by the NF-κB/NLRP3 signaling pathway [0.03%]
凯旋歧柏颗粒通过NF-κB/NLRP3信号通路调控BRD4抑制心肌纤维化
Rui Huang,Gang Luo,Meng-Nan Liu et al.
Rui Huang et al.
Background and aim: Kaixuan Qibi granules (KXGs) have exhibited favorable therapeutic outcomes in addressing a wide range of ailments. They have established their efficacy as a traditional Chinese medicine formulation, pa...
Osthole attenuates trastuzumab-induced cardiotoxicity in mice by enhancing autophagy via regulating the p38MAPK/mTOR signaling pathway [0.03%]
Osthol通过调节p38MAPK/mTOR信号通路增强自噬来减轻曲妥珠单抗诱导的心脏毒性作用于小鼠中
Huan Hou,Yaping Yang,Minyan Zhu et al.
Huan Hou et al.
Background and aim: Trastuzumab (TRZ)-induced cardiotoxicity affects breast cancer patients' quality of life, with no effective prevention currently. Osthole (OST) has been reported to exert cardioprotective effects in ce...
Ethnomedicinal uses, phytochemistry, and biological properties of Ammoides pusilla (Brot.) Breistr: a comprehensive review [0.03%]
Ammoides pusilla（Brot.）Breistr的民族医药用途、植物化学和生物学性质的综合评述
Zineb Lahboub,Adil El Yadini,Meryem El Yadini et al.
Zineb Lahboub et al.
Ammoides pusilla, a member of the Apiaceae family, is a plant with significant medicinal potential, it has been used in traditional practices to treat various health issues like diabetes, fever, cold, respiratory and genital diseases. This ...
Investigating the potential of the Chinese herbal remedy SS-1 for the treatment of Sjögren's syndrome via the interleukin-17 signaling axis [0.03%]
通过白细胞介素-17信号轴探究中药SS-1治疗自身免疫性疾病干燥综合症的潜力
Tran Nhat Phong Dao,Sunday Amos Onikanni,Adewale Oluwaseun Fadaka et al.
Tran Nhat Phong Dao et al.
Background: Sjögren's syndrome (SS) is a prevalent autoimmune disease characterized by dry mouth and dry eyes, which significantly impact patients' quality of life. Chinese medicine has been widely utilized to alleviate ...
Resveratrol supplementation as a non-surgical treatment in periodontitis and related systemic conditions [0.03%]
白藜芦醇补充作为牙周炎及相关系统性疾病的非手术治疗手段
Caterina Vinciguerra,Loredana Bellia,Graziamaria Corbi et al.
Caterina Vinciguerra et al.
Periodontitis is a chronic inflammatory disease of the oral cavity that represents a significant public health problem, especially in geriatric populations. Indeed, periodontal pathogens like Porphyromonas gingivalis (P. gingivalis), the pr...
Chemical characterization of Jing Guan Fang and its application in alleviating coronavirus envelope protein-induced proinflammatory responses in vitro and in vivo [0.03%]
京冠方的化学表征及其在体内外减轻新型冠状病毒包膜蛋白诱导的促炎反应中的应用
Hsin Yeh,Li-Lan Liao,Wei-Hung Hsu et al.
Hsin Yeh et al.
Background and aim: Jing Guan Fang (JGF) is an herbal formulation developed for the prevention of COVID-19 via SARS-CoV-2 infection. In this study, we aimed to clarify the anti-inflammatory effects of JGF on macrophages s...
Investigate the mechanisms of novel verticinone derivatives on lung cancer cell line (A549) by network pharmacology and transcriptome [0.03%]
网络药理学和转录组探讨vertecinone衍生物抗肺癌细胞系(A549)的作用机制研究
Qing Zhou,Hai-Bo Zhou,Jing-Jing Zhang et al.
Qing Zhou et al.
Bulb of Fritillaria ( Bèi Mǔ) has been wildly used in Chinese medicine for serval centuries since its significant therapeutic effects on respiratory diseases, such as cough, expectoration, pneumonia, and bronchial inflammation. Verticinon...