Keratinocyte Piezo1 and CD39 initiated the acupuncture analgesic signals via Co-regulating extracellular ATP mobilization at acupoints [0.03%]
针刺穴位处角质细胞Piezo1和CD39通过协同调控胞外ATP动员启动针刺镇痛信号路径
Yu-Jia Li,Si-Qi Tang,Jie Lin et al.
Yu-Jia Li et al.
Acupoints are the initiation sites for acupuncture analgesic signals, where adenosine signaling plays a crucial role. A comprehensive understanding of this matter will guide clinicians to optimize acupuncture manipulations to improve acupun...
Yinxieling attenuates psoriasis in mice by regulating oxidative stress and lipid mediators to correct immune cell disorder through the NF-κB/Nrf2 signaling pathways [0.03%]
银屑病创新药物阴熙灵通过NF-κB/Nrf2信号通路调控氧化应激和脂质介质纠正免疫细胞紊乱的作用及机制研究
Qihua Yu,Jiagu Ke,Baolin Xie et al.
Qihua Yu et al.
Background: Psoriasis is a chronic skin disease that causes inflammation over time due to immune cell-mediated inflammation, oxidative stress, and lipid mediator imbalance. This study was to investigate the impact of Yinx...
Kerala Ayurveda Ostoact Tablet treats osteoporosis in ovariectomized rat model via regulating RANKL/OPG pathway [0.03%]
卡瑞拉阿育吠陀Ostoact片剂通过调节RANKL / OPG通路治疗卵巢切除大鼠骨质疏松症
Deepa Mandlik,Rutuja Patil,S Arulmozhi et al.
Deepa Mandlik et al.
Background and aim: Kerala Ayurveda Ostoact Tablet (OAT) is a traditional Ayurvedic preparation that might use for the management of joint pain, bone pain and arthritis. The goal of present research was to evaluate the ac...
Tectorigenin attenuates myocardial damage by doxorubicin-induced ferroptosis by activating the p62-Keap1-Nrf2/HO-1/GPX4 axis [0.03%]
金丝桃苷通过激活p62-Keap1-Nrf2/HO-1/GPX4信号轴缓解阿霉素致心肌细胞铁死亡损伤
Like Xie,Sujun Xiao,Qinyi Zhou et al.
Like Xie et al.
Background: Anticancer agent doxorubicin is essential for cancer treatment but often causes cardiotoxicity. Tectorigenin has shown potential cardioprotective effects, but underlying mechanisms remain unclear. We aimed to ...
Xinbao pill attenuated water retention by regulating the CaSR/AQP2 pathway in LAD-induced chronic heart failure rats [0.03%]
新保心宝片通过调节慢性心衰左室重构大鼠CaSR/AQP2信号通路达到利尿消肿的作用
Shiqi Li,Yuanping Wang,Xulan Cui et al.
Shiqi Li et al.
Background: Water retention is one of the important factors in the development and exacerbation of chronic heart failure (CHF). Xinbao Pill (XBP) is widely used as an adjuvant therapy for CHF. However, the therapeutic eff...
Aurantii fructus immaturus (Rutaceae) flavonoid ameliorated constipation by regulating colonic microbiota and miRNA/mRNA network [0.03%]
青皮类黄酮通过调控结肠菌群和miRNA/mRNA网络改善便秘
Yong Wen,Yu Zhan,Li-Juan Du et al.
Yong Wen et al.
Aurantii fructus immaturus flavonoid (AFIF) is the main constituent of Aurantii fructus immaturus (Rutaceae) (AFI), and is effective against constipation. This study explores the mechanism of AFIF against antibiotics-induced constipation (A...
Anti-diabetic activity of aqueous extract of Trichilia prieureana A. Juss leaves in fructose-fed streptozotocin-induced diabetic male Wistar rats [0.03%]
Trichilia prieureana A. Juss叶的水提取物对果糖喂养链尿佐菌素诱导的成年Wistar雄性糖尿病大鼠的抗糖尿病活性研究
Oluwafemi Adeleke Ojo,Musa Toyin Yakubu
Oluwafemi Adeleke Ojo
Background and aim: Ethanolic extract of Trichilia prieureana leaves have been reported to exhibit anti-hyperglycemic activities without detailed information on the anti-diabetic activities. This study investigated the an...
Nao-Xin-Qing tablet inhibits macrophage inflammatory response in atherosclerosis via AMPK-α/SIRT1/PPAR-γ pathway [0.03%]
宁心清咽片通过AMPK-α/SIRT1/PPAR-γ信号通路抑制动脉粥样硬化炎症反应的作用研究
Guiting Zhou,Chenxi Wang,Zhichao Lin et al.
Guiting Zhou et al.
Background and aim: Nao-Xin-Qing (NXQ) tablets are standardized proprietary herbal products containing an extract of Chinese persimmon leaves (Diospyros kaki L.f., World Checklist) and other natural ingredients. NXQ has a...
Khalid Imtiyaz,Mohsin Shafi,Khalid Umar Fakhri et al.
Khalid Imtiyaz et al.
Cancer poses a significant global health challenge, contributing to substantial mortality rates and driving the urgent need for exploration into bioactive compounds with potent anticancer properties. Polydatin (PD), a stilbenoid compound ab...
Mitigation of hypobaric hypoxia induced renal inflammatory alterations by quercetin prophylaxis [0.03%]
染料木素预防对低气压缺氧诱导的肾炎性变化的改善作用研究
Vaishnavi Rathi,Sarada S K Sagi
Vaishnavi Rathi
The objective of the present study is to decipher the role of NF-κB and its associated downstream genes involved in causing inflammation in kidneys of rats under acute hypobaric hypoxia exposure. The study also aims at finding out the effi...