Phase 1 clinical trial evaluating safety, bioavailability, and gut microbiome with a combination of curcumin and ursolic acid in lipid enhanced capsules [0.03%]
一种新型载脂胶囊姜黄素和乌索酸组合物I期临床试验的安全性、生物利用度与肠道菌群评价
Michael A Liss,Furkan Dursun,G Lavender Hackman et al.
Michael A Liss et al.
As screening strategies employ better biomarkers and genetics to identify individuals at an increased risk of prostate cancer, there are currently no chemotherapeutic prevention strategies. With any chemoprevention strategy, the population ...
Molecular study of the KCNJ11 gene and its correlation with Prakriti to preventing and managing type 2 diabetes [0.03%]
KCNJ11基因分子研究及其与体质学说相关性在2型糖尿病防治中的应用研究
Shriti Singh,Sangeeta Gehlot,Neeraj Kumar Agrawal et al.
Shriti Singh et al.
In Ayurveda, every individual is believed to possess a unique entity known as Prakriti, which distinguishes them from others physically, physiologically, and psychologically. This entity also determines an individual's response to a particu...
Chemical profiling and mechanisms of Agarikon pill in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease [0.03%]
桔梗 Pill 的化学谱图及其在香烟烟雾诱发慢性阻塞性肺疾病大鼠模型中的作用机制研究
Aizaiti Keremu,Zulfiye Talat,Xueying Lu et al.
Aizaiti Keremu et al.
Background and aim: Agarikon pill (AGKP), a traditional Chinese herbal formula, and has been used for chronic obstructive pulmonary disease (COPD) treatment clinically. However, the active components and exact pharmacolog...
Bazi Bushen mitigates age-related muscular atrophy by alleviating cellular senescence of skeletal muscle [0.03%]
八臂地龙通过缓解骨骼肌细胞衰老改善肌肉萎缩
Kunxu Niu,Liping Chang,Runtao Zhang et al.
Kunxu Niu et al.
Background and aim: Muscular atrophy is one of the most common age-related conditions characterized by the deterioration of skeletal muscle structures and impaired functions. It is associated with cellular senescence and ...
Natural 7,8-secolignans from Schisandra sphenanthera fruit potently inhibit SARS-CoV-2 3CLpro and inflammation [0.03%]
石楠果实中的天然茋二萜醌类化合物可有效抑制SARS-CoV-2 3CLpro和炎症反应
Bin Li,Liansheng Qiao,Jianuo Zhang et al.
Bin Li et al.
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), turned into a global pandemic, and there remains an urgent demand for specific/targeted drugs for the disease. The 3C-like ...
The chemical composition of Diwu YangGan capsule and its potential inhibitory roles on hepatocellular carcinoma by microarray-based transcriptomics [0.03%]
基于微阵列基因表达谱的迪吾养肝胶囊的化学成分及其潜在的抑癌作用机制研究
Qingxin Shi,Jiangcheng He,Guangya Chen et al.
Qingxin Shi et al.
The Traditional Chinese Medicine compound preparation known as Diwu Yanggan capsule (DWYG) can effectively hinder the onset and progression of hepatocellular carcinoma (HCC), which is recognized worldwide as a significant contributor to fat...
Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism [0.03%]
越南槐根多糖通过调节miR-140-5p相关的抗氧化机制缓解对乙酰氨基酚致肝损伤作用
Liangliang Cai,Lixing Xu,Kai Shen et al.
Liangliang Cai et al.
STRP1, a polysaccharide active ingredient isolated from the traditional Chinese medicine Sophorae tonkinensis radix, has demonstrated a protective effect against acetaminophen (APAP)-induced liver injury (AILI). The underlying molecular mec...
A comprehensive review on ethnomedicinal uses, phytochemistry, toxicology, and pharmacological activities of Dittrichia viscosa (L.) Greuter [0.03%]
狄 trefficia黏液种（L。）植物化学，毒理学和药理活性的综合评论-viscosa革鲁特尔民族医药用途
Rania Jerada,Abdeljalil Er-Rakibi,Abha Cherkani Hassani et al.
Rania Jerada et al.
Dittrichia viscosa is a perennial herb that has been used for generations in traditional medicine to address a variety of diseases, including diabetes, hypertension, cancer, microbial disorders, inflammatory conditions, and wound healing. T...
Electroacupuncture improves articular microcirculation and attenuates cartilage hypoxia in a male rabbit model of knee osteoarthritis [0.03%]
电针改善膝骨关节炎兔模型关节微循环和软骨低氧状态
Ma Weiwei,Du Mei,Lu Juan et al.
Ma Weiwei et al.
Background and aim: Hypoxia of the cartilage has been considered as a potential pathogenic factor in knee osteoarthritis (KOA). Studies have shown that impaired blood perfusion of joint leads to cartilage hypoxia. Electro...
Atractylodes macrocephala Koidz. and Cuscuta chinensis Lam. extract relieves insulin resistance via PI3K/Akt signalling in diabetic Drosophila [0.03%]
苍术和菟丝子提取物通过PI3K / Akt信号减轻糖尿病果蝇的胰岛素抵抗
Yinghong Li,Ye Xu,Biwei Zhang et al.
Yinghong Li et al.
Background and aim: Type-2 diabetes mellitus (T2DM) is mainly characterized by insulin resistance (IR) induced by hyperglycaemia and insufficient insulin secretion. We employed a diabetic fly model to examine the effect a...