Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies [0.03%]
胆管癌瘤反应性肿瘤间质的作用及其新的治疗策略的机会
Massimiliano Cadamuro,Stuart Duncan Morton,Mario Strazzabosco et al.
Massimiliano Cadamuro et al.
Cholangiocarcinoma (CCA) is a very aggressive neoplasm, whose incidence has steadily increased in the last decade. Despite its growing epidemiological impact, therapeutic chances with a curative intent are still limited to surgical resectio...
Histamine and histamine receptor regulation of gastrointestinal cancers [0.03%]
组胺和组胺受体在胃肠肿瘤中的作用及机制研究进展
Lindsey Kennedy,Kyle Hodges,Fanyin Meng et al.
Lindsey Kennedy et al.
Histamine is a neurotransmitter released throughout the body that regulates multiple physiological responses. Primarily histamine is acknowledged for its role in inflammatory reactions to foreign pathogens that enter the body. Aside from in...
Therapeutic actions of melatonin on gastrointestinal cancer development and progression [0.03%]
褪黑素对胃肠道癌症发生发展的治疗作用
Rachael Glenister,Kelly McDaniel,Heather Francis et al.
Rachael Glenister et al.
Melatonin exerts a multitude of physiological functions including the regulation of the sleep cycle and circadian rhythm. Although the synthesis of melatonin in the pineal gland is regulated by changes in the light/dark cycle, the release o...
Progranulin: a novel regulator of gastrointestinal cancer progression [0.03%]
progranulin：胃肠癌症进展的新调节因子
Sharon Demorrow
Sharon Demorrow
Progranulin (PGRN) is a soluble factor that regulates cell proliferation, motility and inflammation. A role for PGRN in the progression of ovarian and breast cancers is well established. However, the expression and subsequent consequences o...
Emilie Viennois,Fengyuan Chen,Didier Merlin
Emilie Viennois
Colitis-associated cancer is the subtype of colorectal cancer that is associated with inflammatory bowel diseases including ulcerative colitis and Crohn's disease. Colorectal cancer is one of the most commonly diagnosed cancers, and is the ...
Dinorah Leyva-Illades,Matthew McMillin,Matthew Quinn et al.
Dinorah Leyva-Illades et al.
Cholangiocarcinoma is a tumor that originates from the neoplastic transformation of the epithelial cells of the intrahepatic or extrahepatic bile ducts. This type of cancer is difficult to diagnose, extremely aggressive, and has very poor p...
Mast cells, disease and gastrointestinal cancer: A comprehensive review of recent findings [0.03%]
肠嗜酸细胞与疾病及胃肠道癌症：近期研究综述
Kyle Hodges,Lindsey Kennedy,Fanyin Meng et al.
Kyle Hodges et al.
Paul Ehrlich, a German scientist, discovered what is known as the mast cell in the late 1800's, which has proven to be an important player in the immune system of vertebrates. Mast cells are ubiquitous throughout the tissues of the human bo...
Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer [0.03%]
白细胞介素6及其受体在肝胆炎症和肿瘤中的关键作用
Christopher Johnson,Yuyan Han,Nathan Hughart et al.
Christopher Johnson et al.
In recent years, the relationship between interleukin-6 (IL-6), hepatobiliary inflammation, and cancer has been studied. It is becoming clear that this cytokine plays an important role in the pathogenesis of both cholangiocarcinoma (CCA, ca...
Mechanisms for nicotine in the development and progression of gastrointestinal cancers [0.03%]
尼古丁在胃肠道癌症发生和发展中的作用机制研究进展
Kendal Jensen,Syeda Afroze,Md Kamruzzaman Munshi et al.
Kendal Jensen et al.
Long-term smoking is major risk factor for a variety of cancers, including those of the gastrointestinal (GI) tract. Historically, nicotine and its derivatives are well known for their role in addiction, and have more recently been document...