Engineered Bispecific Antibodies Achieve Broad and Potent Protection Against Multiple Ebolavirus Species [0.03%]
工程双特异性抗体对多种埃博拉病毒具有广谱和强效的保护作用
Jinge Zhou,Baoyue Zhang,Yanfeng Yao et al.
Jinge Zhou et al.
Ebolaviruses, including EBOV, SUDV, and BDBV, cause severe hemorrhagic fever, yet currently licensed monoclonal antibody (mAb) therapies against EBOV lack cross-species efficacy. While mAbs offer high specificity, favorable safety profiles,...
Evaluation of candidate reference materials for the harmonization of Lassa fever serology [0.03%]
拉沙热血清学标准化候选参考材料的评价
Emma M Bentley,Ndapewa Ithete,Jane Mitchell et al.
Emma M Bentley et al.
Lassa fever is a zoonotic disease endemic to several West African countries, with seasonal outbreaks and potential to cause future epidemics. Vaccines and other medical countermeasures are in development, requiring reliable assays for evalu...
Multicenter Study
Emerging microbes & infections. 2026 Dec;15(1):2640285. DOI:10.1080/22221751.2026.2640285 2026
Development of a novel hybrid alphavirus-Nipah virus pseudovirion for rapid quantification of vaccine-induced neutralization antibodies [0.03%]
一种新型 hybrid alphavirus-Nipah 病毒假病毒的开发，用于快速量化疫苗诱导的中和抗体
Brian Hetrick,Sravya Sowdamini Nakka,Dongyang Yu et al.
Brian Hetrick et al.
Nipah virus (NiV) is an emergent paramyxovirus that causes serious disease in humans and animals. Accurate quantification of neutralizing antibodies (nAB) against NiV is essential for vaccine development. The current standard, the plaque re...
Diagnostic value of pentraxin 3 in plasma and bronchoalveolar lavage fluid for invasive pulmonary aspergillosis in non-neutropenic patients: a prospective multicenter clinical study [0.03%]
血浆和支气管肺泡灌洗液中pentaxin 3诊断非中性粒细胞减少症患者侵袭性肺曲霉病的临床价值：前瞻性多中心研究
Chao Sun,Huanhuan Zhong,Xiaomin Cai et al.
Chao Sun et al.
Objectives: To evaluate the diagnostic performance of pentraxin 3 (PTX3) in plasma and bronchoalveolar lavage fluid (BALF) for invasive pulmonary aspergillosis (IPA) in non-neutropenic patients. Methods: This prospective, multicenter cohort...
Differential Properties of NS1 Glycoproteins in West Nile and Usutu Viruses [0.03%]
西尼罗病毒和乌苏图病毒NS1糖蛋白的差异属性分析
Justine Revel,Jérémy Leroy,Stéphane Delbecq et al.
Justine Revel et al.
AbstractWest Nile virus (WNV) and Usutu virus (USUV) are neurotropic orthoflaviviruses of the Flaviviridae family, transmitted primarily by Culex mosquitoes and maintained in enzootic cycles involving birds. While WNV is a well-established ...
TRIM7 Inhibits Rabies Virus Replication by Promoting K48-Linked Ubiquitination and Degradation of RABV-M [0.03%]
TRIM7通过促进RABV-M的K48连接泛素化和降解来抑制狂犬病毒复制
Hongling He,Weiheng Liang,Wei Lin et al.
Hongling He et al.
ABSTRACTRabies virus (RABV) can infect almost all warm-blooded animals, with a 100% mortality rate once clinical symptoms develop. With no specific therapeutic drugs currently available, rabies remains a major public health threat globally....
A Novel Assay for Quantifying Gn-LRP1-Mediated Neutralizing Antibodies Against Severe Fever with Thrombocytopenia Syndrome Virus [0.03%]
一种量化对严重发热伴血小板减少综合征病毒的Gn-LRP1介导的中和抗体的新测定法
Li-Fen Hu,Meng-Ya Tu,Ding-Ye Zhang et al.
Li-Fen Hu et al.
Accurate and efficient determination of neutralizing antibody (nAb) is critical for assessing individual immune status of severe fever with thrombocytopenia syndrome (SFTS) and identifying key ecological reservoirs of the SFTS virus (SFTSV)...
The Role of Parasite-Derived Vesicles in Modulating Neutrophil Responses in Emerging Human Babesiosis [0.03%]
人新发巴贝斯虫病中寄生虫衍生囊泡在调节中性粒细胞反应中的作用
Haak Simone,Chen Dong,Angana Mukherjee et al.
Haak Simone et al.
AbstractHuman babesiosis is an emerging infectious disease caused by a bloodborne unicellular parasite called Babesia. One of the major species of Babesia that infects humans is Babesia microti, which is transmitted through tick bites durin...
Treatment with low-dose bicistronic immunotherapy mitigates parasite persistence and improves serological and cardiac outcomes in adult mice infected with Trypanosoma cruzi: comparative analysis with benznidazole [0.03%]
低剂量双顺式免疫治疗可减轻成年小鼠感染克氏锥虫后的寄生虫持续存在，并改善血清学和心脏预后：与苯并咪唑 Comparative Analysis
Subhadip Choudhuri PhD,Allison Wyrick BS,Nandadeva Lokugamage PhD et al.
Subhadip Choudhuri PhD et al.
ABSTRACTChagas disease (CD) is caused by Trypanosoma cruzi (Tc) remains difficult to treat in adults, as benznidazole (BZN) has limited curable efficacy and notable adverse effects. This study evaluated a newly-designed immunotherapy withou...
Océane Rieu,Stéphane Descorps-Declère,Anaïs Dufau et al.
Océane Rieu et al.
A novel Merbecovirus, designated Cam-2023, has been identified in Pipistrellus pipistrellus in France through non-invasive surveillance. Phylogenetic analysis demonstrates that Cam-2023 belongs to a Merbecovirus clade previously associated ...