Viral entry defines the hepatitis E virus species barrier in murine hepatocytes [0.03%]
病毒进入界定了小鼠肝细胞中的戊型肝炎病毒种属屏障
Nicola Frericks,Olinda Pinto Veiga,Leyla Sirkinti et al.
Nicola Frericks et al.
The Paslahepevirus balayani hepatitis E virus (HEV) and the distantly related Rocahepevirus ratti rat HEV pose a risk for zoonotic transmission to humans. Despite the broad host range, including its ability to infect certain rodent species,...
Porcine Airway Organoids Reveal Strain-Associated Replication and Epithelial Host Response Signatures of a Reassortant H1N1 Virus [0.03%]
猪呼吸道类器官揭示了 reassortant H1N1 病毒的菌株相关复制和上皮细胞宿主响应特征
Hyewon Lee,Yeojin Shin,Ji-Young Heo et al.
Hyewon Lee et al.
Pigs serve as mixing vessels for influenza A viruses, facilitating reassortment and the emergence of variants with zoonotic potential. Since the 2009 pandemic, human-origin influenza gene segments have been repeatedly detected in swine popu...
Intranasal Drop of Multiplex RNA Therapy for SARS-CoV-2 Infections: Baicalein-Enhanced FEN1 Nuclease Cleaving as a Virus Buster [0.03%]
小柴素增强的FEN1核糖核酸酶切割技术制备抗SARS-CoV-2感染的鼻用滴剂疗法研究
Jiyanuo Cao,Meng Wan,Jiayu Gu et al.
Jiyanuo Cao et al.
Although the acute phase of the SARS-CoV-2 pandemic has subsided, viral persistence and variant evolution continue to challenge existing antiviral strategies. Here, we investigated an intranasal nanomedicine formulation comprising flap-endo...
The Efflux Pump QacA Mediates the Transition to Vancomycin Heteroresistance in Sequence Type 5 Methicillin-Resistant Staphylococcus aureus via Membrane Lipid Reprogramming [0.03%]
色氨酸转运蛋白QacA介导序贯型5耐甲氧西林金黄色葡萄球菌万古霉素异质性耐药的膜脂代谢转换机制
Lin Xi,Qiyu Bian,Ping Yang et al.
Lin Xi et al.
The heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) phenotype in methicillin-resistant S. aureus (MRSA) is a major driver of vancomycin treatment failure. Within the prevalent ST5-MRSA lineage, the efflux pump gene qacA ...
Human pulmonary infection by Brucella suis vaccine strain S2 revealed by genome sequencing in China [0.03%]
中国通过基因组测序发现人肺感染布鲁氏菌疫苗株S2病例
Kun Li,Xiaoyan Zhou,Lingling Tian et al.
Kun Li et al.
Brucellosis the most common zoonosis worldwide. For control and prevention of animal brucellosis, various Brucella vaccines have been developed. Brucella suis S2, a live attenuated vaccine strain proven safe to humans, is widely used in Chi...
Longitudinal in vivo imaging reveals asynchronous, incomplete Nipah virus clearance with prolonged focal CNS involvement in IFNAR-/- mice [0.03%]
纵向活体成像显示小胶质细胞在干扰素受体敲除小鼠脑内对 nipah 病毒的异步不完全清除
Katherine A Davies,Stephen R Welch,Joann D Coleman-McCray et al.
Katherine A Davies et al.
Nipah virus (NiV) infection causes fatal acute respiratory and neurological disease. Survivors may develop long-term sequelae or experience relapsing encephalitis months to years after recovery. The basis of divergent disease trajectories a...
Efficiency of nanovaccines compared with antibiotic therapy in the prevention and immunomodulation of listeriosis [0.03%]
纳米疫苗与抗生素治疗在利斯特菌病预防和免疫调节中的效率比较
Carmen Alvarez-Dominguez,Ricardo Calderón-Gonzalez,David Salcines-Cuevas et al.
Carmen Alvarez-Dominguez et al.
Although the main antimicrobial therapy for adult and neonatal listeriosis is ampicillin, prophylactic treatments are currently lacking. We compared the efficiency of nanovaccines with prenatal or postnatal ampicillin treatments in pregnant...
Comparative Study
Emerging microbes & infections. 2026 Dec;15(1):2706316. DOI:10.1080/22221751.2026.2706316 2026
Seminal fluid enhances monkeypox virus infection via amyloidogenic fibrils [0.03%]
淀粉样原纤维通过精液增强猴痘病毒感染
Emma Torbica,Matthias Denkewitz,Tamara Quick et al.
Emma Torbica et al.
Mpox is a re-emerging zoonosis caused by monkeypox virus (MPXV), with recent outbreaks driven by sexual transmission. How semen contributes to MPXV infection, however, remains unclear. Here, we show that human seminal fluid potently enhance...
Development and Characterization of a Recombinant Bundibugyo Virus Expressing a Fluorescent Reporter Protein [0.03%]
一种表达荧光报告蛋白的布ン迪古YO病毒重组体的构建与鉴定
Shilpi Jain,Éric Bergeron,Mike Flint et al.
Shilpi Jain et al.
AbstractBundibugyo virus disease (BVD), caused by Bundibugyo virus (BDBV), is associated with substantial morbidity and mortality, with previous outbreaks reporting case fatality rates of 30%-50%. The ongoing BDBV outbreak in the Democratic...
Comprehensive genomic characterization of herpes B virus isolated from a wild long-tailed macaque reveals conserved entry mechanisms and zoonotic potential [0.03%]
来自野生长尾猕猴的疱疹B病毒的全面基因组特征分析揭示了保守的进入机制和人畜共患潜力
Weena Paungpin,Somjit Chaiwattanarungruengpaisan,Metawee Thongdee et al.
Weena Paungpin et al.
Herpes B virus (BV; Macacine alphaherpesvirus 1) is a zoonotic alphaherpesvirus endemic in macaques that can cause severe, often fatal encephalomyelitis in humans. However, genomic data from wild macaque populations remain limited. Here, we...