TIM-1 promotes infection with mosquito cell-derived alphaviruses through virion-associated phospholipids [0.03%]
TIM-1通过病毒相关磷脂促进蚊子细胞衍生的alphavirus感染
Ju Eun Yoo,Anja C M de Bruin,Hanna Reßin et al.
Ju Eun Yoo et al.
Human T-cell immunoglobulin and mucin domain 1 (TIM-1) facilitates infection of re-emerging viruses, including alphaviruses, through its phosphatidylserine (PS) binding domain. Although alphaviruses are transmitted to humans via mosquito bi...
Deletion of D345L gene attenuates ASFV and Induces Protection against Homologous and Heterologous challenge by enhancing host innate immunity [0.03%]
D345L基因的敲除可减弱非洲猪瘟病毒并提高宿主先天性免疫诱导保护力
Xuefei Sun,Min Zheng,Nan Li et al.
Xuefei Sun et al.
African swine fever (ASF) is a highly contagious and lethal disease caused by African swine fever virus (ASFV), with a mortality rate approaching up to 100%. At present, the functions of multiple genes of ASFV remain to be elucidated. In th...
A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol [0.03%]
利用CRISPR激活筛选鉴定出CH25H通过靶向可接近的胆固醇限制型流感病毒感染
Jinyu Huang,Kaixiong Ma,Shiping Ding et al.
Jinyu Huang et al.
AbstractInfluenza A viruses (IAVs) cause severe outbreaks with high mortality in birds and humans. A deeper understanding of cell-intrinsic defense mechanisms against influenza viruses is therefore crucial for developing novel antiviral str...
Rapid differentiation of VLA1553 and wild-type ECSA chikungunya strains in the context of an IXCHIQ vaccination campaign [0.03%]
IXCHIQ疫苗接种背景下快速鉴别登革病毒ECSA野毒株和VLA1553毒株
Laura Pezzi,Etienne Frumence,Konrad Wesselmann et al.
Laura Pezzi et al.
AbstractIn 2024-2025, Réunion Island experienced a large outbreak driven by East-Central-South African (ECSA)-2 lineage of chikungunya virus (CHIKV), leading to the implementation of a vaccination campaign using live-attenuated IXCHIQ (VLA...
CD1d knockout swine are permissive to African swine fever virus genotype II infection [0.03%]
CD1d敲除猪易感非洲猪瘟病毒基因Ⅱ型感染
Daniel Madden,Jessie D Trujillo,Shanmugasundaram Elango et al.
Daniel Madden et al.
African swine fever virus (ASFV) is an important pathogen of domestic and wild suids and the causative agent of African swine fever (ASF). ASFV displays a tropism for myeloid cells, predominately of the monocyte/macrophage lineage, which is...
Clinical outcomes of carbapenem therapy in OXA-48-producing Enterobacterales infections: a French multicentre cohort, systematic review, and meta-analysis [0.03%]
碳氢霉烯类治疗OXA-48型酶产生菌感染的临床疗效：法国多中心队列、系统评价和荟萃分析
Laurent Dortet,Charlotte Moreau,Aurélien Dinh et al.
Laurent Dortet et al.
OXA-48-producing Enterobacterales (OXA-48-PE) represent a growing global health threat. Most of OXA-48-PE remain categorized susceptible to carbapenems, which might encourage their use despite uncertain clinical efficacy. This study evaluat...
Spread of carbapenemase-producing Serratia spp. in France from 2016 to 2024: a comparative genomic study [0.03%]
法国2016年至2024年产生碳青霉烯酶的沙雷氏菌传播：一项比较基因组学研究
Inès Rezzoug,Sandrine Bernabeu,Kenza Ouacel et al.
Inès Rezzoug et al.
Carbapenemase-producing Serratia spp. are increasingly implicated in healthcare-associated infections. This study aimed to characterize the genetic diversity, resistance mechanisms and susceptibility to last resort antimicrobials of carbape...
Beyond difficile: three novel toxin B-producing Clostridioides species from human patients with diarrhea [0.03%]
难梭菌之外：来自腹泻患者的人体三种新型毒素B产生产气荚膜梭菌物种
Daniela Aguilar,Thomas Riedel,Sandra Maaß et al.
Daniela Aguilar et al.
Clostridioides difficile infection (CDI), primarily mediated by toxin B (TcdB), is a leading cause of healthcare-associated and community-acquired diarrhea worldwide. Although this genus exhibits substantial genomic diversity, functional st...
A copper uptake ABC transport system is essential for Mycobacterium tuberculosis virulence [0.03%]
一个铜吸收ABC转运系统对结核分枝杆菌致病性是必不可少的
Zhihong Xu,Huang Tang,Meiyi Yan et al.
Zhihong Xu et al.
Mycobacterium tuberculosis (Mtb) is a facultative intracellular pathogen that thrives primarily inside the phagosome of macrophages. A key Mtb survival strategy is to exploit and manipulate metal cation trafficking inside macrophages. Coppe...
Enhanced Immunogenicity and Dose-Sparing Efficacy of SelfAmplifying RNA Vaccines Against Seasonal Influenza Across Subtypes [0.03%]
针对季节性流感跨亚型的自我复制型RNA疫苗具有增强的免疫原性和减毒效果
Mengting Huang,Yun Quan,Ruyi Chen et al.
Mengting Huang et al.
Recent clinical data on seasonal influenza mRNA vaccines have demonstrated suboptimal efficacy against the influenza B virus (IBV). We employed sequence optimization strategies that successfully enhanced the antigen expression of hemaggluti...