Transmitted and pretreatment drug resistance among 69 HIV-1 CRFs in China: the first systematic analysis [0.03%]
中国69种HIV-1型CRF的传播及耐药性首次系统分析
Xiaoyi Yin,Bin Zhao,Minghui An et al.
Xiaoyi Yin et al.
In recent years, an increasing number of HIV-1 circulating recombinant forms (CRFs) have been identified in China. This study presented the first systematic analysis of the molecular epidemiological characteristics and drug resistance mutat...
Henipaviruses at the threshold: preparedness in the era of recurrent spillover [0.03%]
人畜共患病原病毒亨尼帕病毒的防治阈限与策略：一伏袭频繁跨界感染时代的思考
Xinyu Wang,Wenhong Zhang
Xinyu Wang
Henipaviruses remain high-consequence zoonotic pathogens characterized by recurrent spillover, severe disease, and limited but consequential human-to-human transmission. In this commentary, we frame henipaviruses as "threshold pathogens": a...
Extracellular vesicles participate in proteostasis and heat shock adaptation in Plasmodium falciparum [0.03%]
恶性疟原虫释放的胞外囊泡参与蛋白稳态和热激反应
Yunuen Avalos-Padilla,Lucía Román-Álamo,Inés Bouzón-Arnáiz et al.
Yunuen Avalos-Padilla et al.
Heat shock is a hallmark of clinical malaria, where Plasmodium falciparum parasites are exposed to recurrent febrile episodes exceeding 40 °C and imposing acute proteotoxic stress. Parasite survival under these conditions relies on efficie...
Therapeutic Approaches Against Dengue Virus: Current Status of Vaccines, Antivirals, and Monoclonal Antibodies [0.03%]
登革病毒的治疗策略：疫苗、抗病毒药物和单克隆抗体的现状
Hawa Sophia Bouzidi,Xavier de Lamballerie,Franck Touret
Hawa Sophia Bouzidi
Dengue virus (DENV) continues to pose a major global health challenge, with widespread distribution, frequent outbreaks, and four antigenically distinct serotypes complicating efforts for effective prevention and treatment. Despite decades ...
Identification of Prohibitin (PHB) as an Entry Factor of Highly Pathogenic Coronaviruses Using Metabolic Glycoengineering and Photo-Crosslinking Techniques [0.03%]
利用代谢型糖工程和光交联技术鉴定 prohibitin（PHB）为高致病性冠状病毒的进入因子
Xingxing Zhu,Xiaoyang Wang,Yiming Wang et al.
Xingxing Zhu et al.
Coronaviruses (CoVs) rely on host surface factors to mediate viral attachment and entry, yet conserved host cofactors shared across different CoVs remain poorly defined. Here, we established a host-factor capture platform based on metabolic...
Compartmentalized cytokine networks and systemic immune remodelling in bovine mammary H5N1 infection [0.03%]
牛乳腺H5N1感染的隔室细胞因子网络和全身免疫重塑
Gagandeep Singh,Konner Cool,Shristi Ghimire et al.
Gagandeep Singh et al.
Highly pathogenic avian influenza A H5N1 has recently expanded its mammalian host range; in 2024, genotype B3.13 emerged in U.S. dairy cattle with pronounced mammary tropism. In the past, Influenza A virus immunology has been characterized ...
Specific plasmid profiles of Clostridium butyricum associated with grouped cases of necrotizing enterocolitis [0.03%]
特定质粒谱型的芽孢杆菌与坏死性小肠结肠炎密切相关
Yousra Mikrat,Anthony Adjamian,Zineb Elidrissi et al.
Yousra Mikrat et al.
Necrotizing enterocolitis (NEC) is an unpredictable condition that is commonly encountered in neonatal intensive care units. NEC considered one of the most severe gastrointestinal diseases affecting preterm infants and is often fatal. In th...
Distinct cytotoxic cell subsets underlie protective and non-protective immunity to African swine fever virus [0.03%]
不同的细胞毒性细胞亚群决定了非洲猪瘟病毒的保护性和非保护性免疫反应
David Marín-Moraleda,Aida Tort-Miró,Enrique Ezcurra et al.
David Marín-Moraleda et al.
Limited understanding of African swine fever (ASF) immunity remains a major barrier to the rational development of safe and effective vaccines. While antibody-mediated protection is still poorly defined, growing evidence highlights a centra...
The mouse-lethal H5N1 influenza virus carrying the PB2-384L/443R/460M characteristics acquired in avian hosts can effectively utilize human ANP32A/B proteins [0.03%]
携带PB2-384L/443R/460M特征的致死小鼠型H5N1流感病毒可以有效利用人类ANP32A/B蛋白
Weipeng Lin,Guohua Deng,Xin Xing et al.
Weipeng Lin et al.
ABSTRACTThe species-specific acidic nuclear phosphoprotein 32 kDa members (ANP32A/B) play a key role in restricting the function of avian influenza virus polymerase in mammalian host. Avian influenza viruses, upon replicating in humans, may...
Jiaming Li,Chunge Zhang,Ren Li et al.
Jiaming Li et al.
In 2024, we identified and sequenced 52 avian influenza A (H9N2) virus strains in Laos. Using the established H9N2 genomic classification system, a novel HA gene clade of the A/chicken/Beijing/1/94-like (BJ/94-like) lineage, designated Clad...