Characterization of oseltamivir-resistant A(H5N1) clade 2.3.4.4b, genotype D1.1 variants identified in poultry farms of British Columbia, Canada [0.03%]
加拿大英属哥伦比亚省家禽养殖场鉴定出的Oseltamivir耐药A(H5N1)谱系2.3.4.4b、基因型D1.1变异株的表征
Maxime Cochin,Yacine Abed,Robert Vendramelli et al.
Maxime Cochin et al.
Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b, genotype D1.1, are responsible for widespread outbreaks in poultry and continue to cause sporadic, sometimes severe, human infections. Herein, we characterized a wild-type...
An integrated review of monkeypox: from pathogen and epidemiology to diagnostics, control, and challenges [0.03%]
人猴痘病毒综合述评：从病原及流行病学到诊断、防控和挑战
Wujian Li,Qiyuan Yang,Wenyu Xie et al.
Wujian Li et al.
Monkeypox (Mpox) is a zoonotic disease caused by MPXV and remains a threat to global public health. MPXV Clade Ib has higher mortality, whereas Clade IIb exhibits widespread international transmission. WHO has twice designated mpox epidemic...
Immunodominant B-cell epitopes for precision surveillance of Plasmodium vivax malaria [0.03%]
恶性疟原虫精准监控的主导B细胞抗原表位
Hanqing Zhao,Yinshan Zhu,Jingxian Yin et al.
Hanqing Zhao et al.
Asymptomatic Plasmodium vivax infections sustain transmission and derail elimination efforts, yet these hidden reservoirs evade current diagnostics. Here, we integrated computational immunology with empirical serology to discover high-perfo...
iNOS/NO-Induced autophagy primes PANoptosis as the central driver of streptococcal toxic shock-like syndrome in zoonotic Streptococcus suis infection [0.03%]
诱导的自噬引发的PANoptosis是猪链球菌感染引起的类毒素休克综合征的主要驱动因素
Huimin Gong,Bin Ma,Ran Zhuo et al.
Huimin Gong et al.
Streptococcus suis is a major zoonotic pathogen that causes human fulminant meningitis and streptococcal toxic shock-like syndrome (STSLS), the latter being driven by dysregulated inflammatory responses and explosive cytokine storms. It rem...
Henrik Fritsch,Prerna Arora,Miaomiao Yan et al.
Henrik Fritsch et al.
Influenza A viruses (IAVs) have recently expanded their host range to bovine species, raising critical questions about tissue tropism, viral replication capacity, and impacts on dairy production and zoonotic risk. Extensive shedding of high...
Development and validation of the AI-predictive ParaScout In-Vitro Diagnostic (IVD) system for the microscopic detection of gastro-intestinal helminths in stool [0.03%]
AI预测型ParaScout体外诊断（IVD）系统在粪便中检测消化道线虫的研制与验证
Ihor Feoktistov,Rob Koelewijn,Chris Tieken et al.
Ihor Feoktistov et al.
AbstractThe comprehensive method to detect gastrointestinal infections is still microscopic examination of stool specimens. However, manual microscopic examination is laborious, and its accuracy is highly observer-dependent. Therefore, we h...
Genomic landscape and phylogenetic insights of Burkholderia pseudomallei over two decades in southern China and its global surveillance [0.03%]
中国华南地区20年间Burkholderia pseudomallei的基因组景观、系统发育学见解及其全球监测
Hua Wu,Zichen Lei,Shaowen Chen et al.
Hua Wu et al.
Melioidosis, caused by Burkholderia pseudomallei, is an endemic infectious disease with high mortality in tropical and subtropical regions. Large-scale epidemiological data remain insufficient in China, while comprehensive data integrating ...
Quantifying the community transmission of Mycobacterium tuberculosis in a rapidly growing Chinese city: a nine-year population-based genomic and spatial analysis [0.03%]
中国快速发展的城市中社区传播的结核分枝杆菌流行病学特征：基于人群的九年基因组和空间分析
Xi Zhu,Yunxia Wang,Liai Peng et al.
Xi Zhu et al.
Tuberculosis (TB) remains a significant public health threat in urbanizing regions of China, where shifting population dynamics and migration may amplify TB transmission. We conducted a nine-year prospective epidemiological study of culture...
Spatiotemporal dynamics of the unprecedented chikungunya outbreak in Guangdong, China [0.03%]
中国广东白纹伊蚊 borne 埃博拉病毒病时空动态模型研究
Hengcong Liu,Wen Zheng,Edward C Holmes et al.
Hengcong Liu et al.