Seminal fluid enhances monkeypox virus infection via amyloidogenic fibrils [0.03%]
淀粉样原纤维通过精液增强猴痘病毒感染
Emma Torbica,Matthias Denkewitz,Tamara Quick et al.
Emma Torbica et al.
Mpox is a re-emerging zoonosis caused by monkeypox virus (MPXV), with recent outbreaks driven by sexual transmission. How semen contributes to MPXV infection, however, remains unclear. Here, we show that human seminal fluid potently enhance...
Development and Characterization of a Recombinant Bundibugyo Virus Expressing a Fluorescent Reporter Protein [0.03%]
一种表达荧光报告蛋白的布ン迪古YO病毒重组体的构建与鉴定
Shilpi Jain,Éric Bergeron,Mike Flint et al.
Shilpi Jain et al.
AbstractBundibugyo virus disease (BVD), caused by Bundibugyo virus (BDBV), is associated with substantial morbidity and mortality, with previous outbreaks reporting case fatality rates of 30%-50%. The ongoing BDBV outbreak in the Democratic...
Comprehensive genomic characterization of herpes B virus isolated from a wild long-tailed macaque reveals conserved entry mechanisms and zoonotic potential [0.03%]
来自野生长尾猕猴的疱疹B病毒的全面基因组特征分析揭示了保守的进入机制和人畜共患潜力
Weena Paungpin,Somjit Chaiwattanarungruengpaisan,Metawee Thongdee et al.
Weena Paungpin et al.
Herpes B virus (BV; Macacine alphaherpesvirus 1) is a zoonotic alphaherpesvirus endemic in macaques that can cause severe, often fatal encephalomyelitis in humans. However, genomic data from wild macaque populations remain limited. Here, we...
The Impact of HIV Coinfection on Mpox Patients: A Systematic Review and Meta-Analysis [0.03%]
HIV合并感染对_mpox_患者的影响：系统回顾和荟萃分析
Lei Ji,Defu Yuan,Fuchun Wang et al.
Lei Ji et al.
A substantial proportion of mpox cases occur in people coinfected with HIV. However, the extent to which HIV coinfection and HIV-related immune status influence clinical outcomes, including disease severity and coinfections, remains incompl...
Spread of Chlamydia pneumoniae ST16 during the 2024-2025 outbreak in France [0.03%]
法国2024-2025年爆发期间肺炎衣原体ST16的传播
Arabella Touati,Cécile Bébéar,Olivia Peuchant;CHLAPTY study group
Arabella Touati
A resurgence of Chlamydia pneumoniae respiratory infections was observed in France during 2024-2025. We aimed to characterise the genotypic distribution of C. pneumoniae during the outbreak period using positive respiratory samples from inf...
Molecular evidence of neuroinvasive Sindbis virus infection in humans: detection in cerebrospinal fluid by next generation sequencing [0.03%]
人神经侵袭性辛德毕斯病毒的分子证据：利用高通量测序技术从脑脊液中检测病毒
Maria Grazia Cusi,Gianni Gori Savellini,Chiara Cassol et al.
Maria Grazia Cusi et al.
Sindbis virus (SINV) is a mosquito borne alphavirus causing seasonal outbreaks in northern Europe, Africa and Russia. Neurological involvement in humans is poorly documented, and detection in cerebrospinal fluid (CSF) has not previously bee...
Ebola virus and Sudan virus infection in humans: a comparison to inform vaccine research and development [0.03%]
埃博拉病毒和苏丹病毒的人类感染情况比较：为疫苗研究与开发提供参考信息
Hilary S Whitworth,Gabriella Quintard,Victoria Oyeneye et al.
Hilary S Whitworth et al.
Recent outbreaks of Ebola virus (EBOV) disease (EVD) and Sudan virus (SUDV) disease (SVD) in sub-Saharan Africa underscore the ongoing public health threat posed by orthoebolaviruses. While highly effective vaccines are licensed for prevent...
Preclinical characterization of HEC116094, an oral inhibitor of the influenza A virus polymerase PB2 subunit [0.03%]
HEC116094口服抑制剂表征为一种流感A病毒聚合酶PB2亚基的抑制剂：临床前研究
Longyu Nie,Yunfu Chen,Pu Wang et al.
Longyu Nie et al.
Influenza A virus remains a global health threat due to its high mutation rate and its resistance to existing neuraminidase and polymerase inhibitors. The polymerase basic protein 2 (PB2) subunit is a promising target for novel therapeutics...
Emerged N193S mutation of PA-X protein disabled the immunity of mucosal dendritic cells for regulating virulence of clade 2.3.4.4b H5 subtype virus [0.03%]
PA-X蛋白N193S突变通过抑制黏膜树突状细胞免疫逃逸子毒H5亚型病毒的致病性
Xinyu Miao,Xing Xu,Yixuan Han et al.
Xinyu Miao et al.
In recent years, H5 subtype highly pathogenic avian influenza viruses (HPAIVs), especially clade 2.3.4.4b, have posed a global threat to poultry, cattle, and public health. Bioinformatics analysis of H5 subtype AIVs from 2000 to 2023 reveal...
IS481-based pertussis positivity transition from preschool to school-aged children and the ptxP3 predominance in high-load subset: a digital platform surveillance study in China [0.03%]
基于IS481的白喉杆菌阳性从学龄前儿童到学龄儿童的变化以及高载量组中ptxP3占优势：中国一项数字平台监测研究
Chunyan Xiang,Zichen Lei,Tingting You et al.
Chunyan Xiang et al.
China experienced a massive pertussis resurgence in 2024. We aimed to characterize the epidemiological trends, clinical symptoms, and molecular evolution of Bordetella pertussis using a large-scale, home-based surveillance platform in four ...