Organoid-based evaluation of SA55 and Pemivibart against evolving SARS-CoV-2 variants [0.03%]
SA55和Pemivibart对抗不断进化的SARS-CoV-2变异株的类器官评估
Zhixin Wan,Ying Zhou,Fanchong Jian et al.
Zhixin Wan et al.
Pemivibart, a class 1/4 monoclonal antibody (mAb), is currently the only FDA-authorized SARS-CoV-2 mAb under an Emergency Use Authorization (EUA) in clinical use. The emergence of subvariants, including KP.3.1.1 and XFG, raises concerns abo...
Genetic evolution, phylodynamics, geographic spread of H9N2 avian influenza viruses in China from 2014 to 2025: an increasing potential zoonotic risk [0.03%]
中国2014-2025年H9N2禽流感病毒的基因进化、系统发育动力学及地理传播：潜在人畜共患病风险加剧
Zifeng Pang,Peiting Zhong,Cuishan Mai et al.
Zifeng Pang et al.
Subtype H9N2 of the avian influenza virus (AIV) poses a growing threat to the poultry industry and public health. However, since 2014, there has been no systematic study of its genetic evolution, genotype, spatial dynamics, and pathogenicit...
Carbapenemase-producing Klebsiella oxytoca complex in France (2017-2023): Molecular epidemiology integrated with virulence and biofilm phenotypes [0.03%]
法国(2017-2023年)产碳青霉烯酶克雷伯菌oxytoca复合群：结合毒力和生物膜表型的分子流行病学研究
Inès Rezzoug,Océane Vanparis,Joséphine Poiraud et al.
Inès Rezzoug et al.
Objectives: This study analysed a large French collection of carbapenemase-producing Klebsiella oxytoca complex (KoC) isolates (2017-2023) to map species and carbapenemase distributions and identify emerging lineages. We ...
Viral entry defines the hepatitis E virus species barrier in murine hepatocytes [0.03%]
病毒进入界定了小鼠肝细胞中的戊型肝炎病毒种属屏障
Nicola Frericks,Olinda Pinto Veiga,Leyla Sirkinti et al.
Nicola Frericks et al.
The Paslahepevirus balayani hepatitis E virus (HEV) and the distantly related Rocahepevirus ratti rat HEV pose a risk for zoonotic transmission to humans. Despite the broad host range, including its ability to infect certain rodent species,...
Porcine Airway Organoids Reveal Strain-Associated Replication and Epithelial Host Response Signatures of a Reassortant H1N1 Virus [0.03%]
猪呼吸道类器官揭示了 reassortant H1N1 病毒的菌株相关复制和上皮细胞宿主响应特征
Hyewon Lee,Yeojin Shin,Ji-Young Heo et al.
Hyewon Lee et al.
Pigs serve as mixing vessels for influenza A viruses, facilitating reassortment and the emergence of variants with zoonotic potential. Since the 2009 pandemic, human-origin influenza gene segments have been repeatedly detected in swine popu...
Intranasal Drop of Multiplex RNA Therapy for SARS-CoV-2 Infections: Baicalein-Enhanced FEN1 Nuclease Cleaving as a Virus Buster [0.03%]
小柴素增强的FEN1核糖核酸酶切割技术制备抗SARS-CoV-2感染的鼻用滴剂疗法研究
Jiyanuo Cao,Meng Wan,Jiayu Gu et al.
Jiyanuo Cao et al.
Although the acute phase of the SARS-CoV-2 pandemic has subsided, viral persistence and variant evolution continue to challenge existing antiviral strategies. Here, we investigated an intranasal nanomedicine formulation comprising flap-endo...
The Efflux Pump QacA Mediates the Transition to Vancomycin Heteroresistance in Sequence Type 5 Methicillin-Resistant Staphylococcus aureus via Membrane Lipid Reprogramming [0.03%]
色氨酸转运蛋白QacA介导序贯型5耐甲氧西林金黄色葡萄球菌万古霉素异质性耐药的膜脂代谢转换机制
Lin Xi,Qiyu Bian,Ping Yang et al.
Lin Xi et al.
The heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) phenotype in methicillin-resistant S. aureus (MRSA) is a major driver of vancomycin treatment failure. Within the prevalent ST5-MRSA lineage, the efflux pump gene qacA ...
Human pulmonary infection by Brucella suis vaccine strain S2 revealed by genome sequencing in China [0.03%]
中国通过基因组测序发现人肺感染布鲁氏菌疫苗株S2病例
Kun Li,Xiaoyan Zhou,Lingling Tian et al.
Kun Li et al.
Brucellosis the most common zoonosis worldwide. For control and prevention of animal brucellosis, various Brucella vaccines have been developed. Brucella suis S2, a live attenuated vaccine strain proven safe to humans, is widely used in Chi...
Longitudinal in vivo imaging reveals asynchronous, incomplete Nipah virus clearance with prolonged focal CNS involvement in IFNAR-/- mice [0.03%]
纵向活体成像显示小胶质细胞在干扰素受体敲除小鼠脑内对 nipah 病毒的异步不完全清除
Katherine A Davies,Stephen R Welch,Joann D Coleman-McCray et al.
Katherine A Davies et al.
Nipah virus (NiV) infection causes fatal acute respiratory and neurological disease. Survivors may develop long-term sequelae or experience relapsing encephalitis months to years after recovery. The basis of divergent disease trajectories a...
Efficiency of nanovaccines compared with antibiotic therapy in the prevention and immunomodulation of listeriosis [0.03%]
纳米疫苗与抗生素治疗在利斯特菌病预防和免疫调节中的效率比较
Carmen Alvarez-Dominguez,Ricardo Calderón-Gonzalez,David Salcines-Cuevas et al.
Carmen Alvarez-Dominguez et al.
Although the main antimicrobial therapy for adult and neonatal listeriosis is ampicillin, prophylactic treatments are currently lacking. We compared the efficiency of nanovaccines with prenatal or postnatal ampicillin treatments in pregnant...
Comparative Study
Emerging microbes & infections. 2026 Dec;15(1):2706316. DOI:10.1080/22221751.2026.2706316 2026