HA protein acetylation modulates replication, pathogenicity, and immunogenicity of influenza virus and facilitates live-attenuated vaccine design [0.03%]
流感病毒的HA蛋白乙酰化调控病毒复制、致病性和免疫原性并促进活疫苗的设计
Mingqing Wu,Meimei Wang,Xinyu Zeng et al.
Mingqing Wu et al.
Lysine acetylation, a form of protein post-translational modifications (PTM), is known to play crucial roles in regulating cellular and physiological processes. In this study, for the first time, lysine acetylation sites were identified on ...
Genome analysis and machine learning-based feature selection strategy reveal potential drug-resistance determinants in Nakaseomyces glabratus [0.03%]
基因分析和基于机器学习的功能选择策略揭示了Nakaseomyces glabratus中潜在的耐药决定因子
Qiqi Wang,Runhong Chen,Xin Cao et al.
Qiqi Wang et al.
Invasive candidiasis caused by Nakaseomyces glabratus is of great concern due to high morbidity and mortality, especially antifungal resistance. To identify genomic signatures, which significantly link to drug-resistance, is of great signif...
Crimean-Congo Hemorrhagic Fever Virus Localization and Shedding in the Reproductive Tract of Lethal and Survivor Mouse Models [0.03%]
小鼠致命和非致命型克里米亚-刚果出血热病毒定位及传播研究
Teresa E Sorvillo,Jana M Ritter,Stephen R Welch et al.
Teresa E Sorvillo et al.
Hemorrhagic fever viruses have been shown to localize to immune-privileged sites, including the reproductive tract, raising important questions about long-term persistence and the potential for sexual transmission. Anecdotal evidence of sex...
Epidemiology, Genetic Dynamics, and Transmission of the mcr-1 Gene in China [0.03%]
中国耐碳青霉烯类抗生素基因mcr-1的流行病学、遗传进化及传播动力学研究
Boqian Wang,Zhong Li,Mingliang Chen et al.
Boqian Wang et al.
Colistin is a broad-spectrum antibiotic that kills bacteria through the disruption of the cell membrane, making it effective against various bacterial infections. Since the first global report of mobile colistin-resistant (mcr-1)-positive b...
Effectiveness of DTaP-IPV//PRP-T vaccine against pertussis among infants and toddlers in Zhejiang, China: a retrospective cohort study [0.03%]
浙江婴幼儿及幼童使用DTaP-IPV/Hib联合疫苗预防百日咳效果：回顾性队列研究
Yao Zhu,Peihan Chi,Yang Zhou et al.
Yao Zhu et al.
Pertussis poses a significant risk, especially to infants. Although the pentavalent vaccine DTaP-IPV//PRP-T was introduced in China in 2010, real-world data on vaccine effectiveness (VE) in the country are limited. We conducted a retrospect...
Isolation and genomic characterization of Chikungunya virus during the 2025 outbreak in Foshan, China [0.03%]
中国佛山2025年爆发期间登革热病毒的分离和基因组特征分析
Changyun Sun,Lu Zhang,Haisu Yi et al.
Changyun Sun et al.
Chikungunya virus (CHIKV) caused more than 10,000 infections in Foshan, Guangdong, in 2025. Using plasma from acute-phase patients, we successfully isolated infectious CHIKV, confirmed by focus-forming assay and transmission electron micros...
Transmission of carbapenemase-producing Enterobacter in Ontario, Canada: A Retrospective Genomic Analysis [0.03%]
加拿大安大略州产碳青霉烯酶肠杆菌的传播：一项回顾性基因组分析
Conrad Izydorczyk,Robyn Lee,Laura Mataseje et al.
Conrad Izydorczyk et al.
Carbapenemase-producing Enterobacter (CP-Ent) are the third most prevalent species of CP-Enterobacteriaceae worldwide and exhibit greater strain diversity than other CP-species. This study aimed to describe the genomic epidemiology of CP-En...
Deep sequencing reveals underestimated burden of integrase inhibitor resistance mutations in people living with HIV: a global individual patient data meta-analysis [0.03%]
深度测序揭示了HIV感染者的整合酶抑制剂耐药突变负担被低估：一项全球性个体患者数据荟萃分析
Defu Yuan PhD,Fei Zhao MM,Yangyang Liu PhD et al.
Defu Yuan PhD et al.
Integrase strand transfer inhibitors (INSTIs) have emerged as cornerstone agents in global antiretroviral therapy, though growing drug resistance presents clinical challenges. Conventional Sanger sequencing may underestimate the burden of l...
The oral nucleoside drug VV116 is a promising candidate for treating Nipah virus infection [0.03%]
口服核苷药物VV116有望成为尼帕病毒治疗药物候选者
Yumin Zhang,Yanfeng Yao,Shufen Song et al.
Yumin Zhang et al.
New resistance threat in difficult-to-treat resistance Pseudomonas aeruginosa co-producing AFM and KPC carbapenemases: plasmid dynamic transfer and global phylogeography perspective [0.03%]
产AFM和KPC型碳青霉烯酶的防治困难的难治病原体铜绿假单胞菌的新耐药性威胁：质粒动态转移及全球谱系地理学视角
Haiyang Liu,Jiayao Yao,Chongmei Tian et al.
Haiyang Liu et al.
Metallo-β-lactamase (MBL) production is one of the primary carbapenem resistance mechanisms in carbapenem-resistant Pseudomonas aeruginosa (CRPA). The emergence of the novel MBL gene blaAFM poses a significant threat to global public healt...