A bispecific antibody targeting conserved hemagglutinin epitopes confers broad protection against H7 avian influenza and accelerates viral clearance via localized respiratory delivery [0.03%]
通过局部呼吸道给药靶向保守血凝素表位的双特异性抗体可广谱预防H7型禽流感并加快病毒清除
Han Wu,Fan Yang,Ping Wang et al.
Han Wu et al.
The continuous antigenic drift of zoonotic H7 avian influenza viruses remains a significant global public health threat. While monoclonal antibodies (mAbs) targeting the hemagglutinin (HA) head offer potent neutralization, their efficacy is...
A genome-wide CRISPR knockout screen identified host genes essential for Brucella invasion and intracellular survival [0.03%]
利用CRISPR敲除筛选技术鉴定布鲁氏菌感染和胞内增殖所必须的宿主基因
Xinhui Wang,Sujun Wu,Yige Ding et al.
Xinhui Wang et al.
For Brucella spp., the ability to invade and survive within host macrophages is essential for causing chronic infections in their mammalian hosts. In this study, a genome-wide CRISPR knockout screen was performed for the first time in human...
O'nyong-nyong virus adaptive mutations in non-structural protein 1 and 3 enhance RNA replication and overcome FHL1 requirement [0.03%]
O'nyong-nyong病毒的非结构蛋白1和3的适应性突变增强了RNA复制并克服了FHL1需求
Tessy A H Hick,Karsten Cirksena,Magnus Evander et al.
Tessy A H Hick et al.
Arthritogenic alphaviruses, like o'nyong-nyong virus (ONNV), cause debilitating musculoskeletal diseases and are geographically expanding. To predict their emergence, we seek to better understand evolutionary mechanisms that enable changes ...
Early Detection of Pertussis Related Activity by Wastewater Surveillance of Bordetella pertussis- and Bordetella parapertussis- Associated DNA Concentrations in Osaka, Japan [0.03%]
日本大阪府通过污水监测百日咳杆菌和副百日咳杆菌相关DNA浓度早期发现百日咳相關活動
Koichiro Suzuki,Daisuke Motooka,Naomi Sakon et al.
Koichiro Suzuki et al.
Pertussis causes recurrent outbreaks worldwide. Clinical surveillance can be affected by healthcare-seeking behaviour, diagnostic practices, testing sensitivity, and reporting delays. This study evaluated the utility of wastewater surveilla...
RpoE-Mediated Virulence Attenuation Elicits Protective Immunity in Hypervirulent Klebsiella pneumoniae [0.03%]
RpoE介导的毒力减弱诱发高毒性的肺炎克雷伯菌免疫保护作用
Yaxuan Zhai,Qiyuan Jin,Jiawen Shi et al.
Yaxuan Zhai et al.
The global emergence of hypervirulent Klebsiella pneumoniae (hvKP) and extensively drug-resistant (XDR) phenotypes has precipitated a severe public health crisis with limited therapeutic options. In particular, the hypervirulent ST65 and ST...
A Rapid Detection of Nipah Virus Nucleocapsid Antigen in Inactivated Viral Cultures [0.03%]
一种快速检测灭活病毒培养物中尼帕病毒核衣壳抗原的方法
Gyeongmu Choi,Jung Kim,Hansaem Lee et al.
Gyeongmu Choi et al.
Nipah virus (NiV) is a highly lethal zoonotic henipavirus that causes severe respiratory disease and encephalitis and remains a priority pathogen for outbreak preparedness. Timely diagnosis is essential for containment, yet nucleic acid-bas...
Correction [0.03%]
改正措施
Published Erratum
Emerging microbes & infections. 2026 Dec;15(1):2712857. DOI:10.1080/22221751.2026.2712857 2026
Norovirus inter-species transmission in an ex vivo model is dependent on virus internalization capacity [0.03%]
诺如病毒科物种间传播依赖于病毒的胞吞能力
Nele Villabruna,Myra Hosmillo,Ian Goodfellow et al.
Nele Villabruna et al.
Human noroviruses (HuNoV) are the most common cause of viral gastroenteritis worldwide, causing sporadic cases and outbreaks. Noroviruses that infect wild and domestic animals, including pigs and dogs, are genetically related to human norov...
A bivalent inactivated influenza vaccine incorporating epitope-optimized surface proteins confers cross-protective immunity against H9N2 influenza virus [0.03%]
一种嵌合优化抗原的亚单位流感疫苗对人流感病毒H9N2的交叉保护作用
Mengchan Hao,Yiwei Guan,Meng Xu et al.
Mengchan Hao et al.
AbstractThe H9N2 avian influenza virus (AIV) has caused substantial economic losses to the global poultry industry and poses a zoonotic threat to humans. Vaccination constitutes a pivotal strategy for the prevention and control of H9N2 AIVs...