Comprehensive Predictions of Mef2-Mediated Chromatin Loops, Which May Inhibit Ubx Binding by Blocking Low-Affinity Binding Sites [0.03%]
综合预测Mef2介导的染色质环化作用并抑制Ubx结合以阻断低亲和力结合位点
Katrin Domsch
Katrin Domsch
Gene regulation depends on the interaction between chromatin-associated factors, such as transcription factors (TFs), which promote chromatin loops to ensure tight contact between enhancer and promoter regions. So far, positive interactions...
The Loss of Tafazzin Transacetylase Activity Is Sufficient to Drive Testicular Infertility [0.03%]
Tau蛋白乙酰基转移酶活性丧失足以导致生精功能障碍
Paige L Snider,Elizabeth A Sierra Potchanant,Catalina Matias et al.
Paige L Snider et al.
Barth syndrome (BTHS) is a rare, infantile-onset, X-linked mitochondriopathy exhibiting a variable presentation of failure to thrive, growth insufficiency, skeletal myopathy, neutropenia, and heart anomalies due to mitochondrial dysfunction...
Transcriptomic Evidence for Cell-Autonomous Sex Differentiation of the Gynandromorphic Fat Body in the Silkworm, Bombyx mori [0.03%]
家蚕(Silkworm Bombyx mori)阴阳虫体内异性的脂肪体细胞自主性分化的转录组证据
Fumiko Yamamoto,Takeshi Yokoyama,Yan Su et al.
Fumiko Yamamoto et al.
The classic model of sex determination in insects suggests that they do not have sex hormones and that sex is determined in a cell-autonomous manner. On the other hand, there is accumulating evidence that the development of secondary sexual...
Methyl-Beta-Cyclodextrin Restores Aberrant Bone Morphogenetic Protein 2-Signaling in Bone Marrow Stromal Cells Obtained from Aged C57BL/6 Mice [0.03%]
甲基-β-环糊精可恢复来自老年C57BL/6小鼠的骨髓基质细胞中异常的骨形态生成蛋白2信号通路功能
Daniel Halloran,Venu Pandit,Kelechi Chukwuocha et al.
Daniel Halloran et al.
During aging, disruptions in various signaling pathways become more common. Some older patients will exhibit irregular bone morphogenetic protein (BMP) signaling, which can lead to osteoporosis (OP)-a debilitating bone disease resulting fro...
Prosaposin/Saposin Expression in the Developing Rat Olfactory and Vomeronasal Epithelia [0.03%]
大鼠嗅觉和犁鼻上皮发育过程中Prosaposin/Saposin的表达
Kai Kitamura,Kyoko Saito,Takeshi Homma et al.
Kai Kitamura et al.
Prosaposin is a glycoprotein widely conserved in vertebrates, and it acts as a precursor for saposins that accelerate hydrolysis in lysosomes or acts as a neurotrophic factor without being processed into saposins. Neurogenesis in the olfact...
How the Oocyte Nucleolus Is Turned into a Karyosphere: The Role of Heterochromatin and Structural Proteins [0.03%]
卵子核仁如何转变为核球：异染色质和结构蛋白的作用
Venera Nikolova,Maya Markova,Ralitsa Zhivkova et al.
Venera Nikolova et al.
Oocyte meiotic maturation includes large-scale chromatin remodeling as well as cytoskeleton and nuclear envelope rearrangements. This review addresses the dynamics of key cytoskeletal proteins (tubulin, actin, vimentin, and cytokeratins) an...
Samuel Liu,Kellianne D Alexander,Michael M Francis
Samuel Liu
As nervous systems mature, neural circuit connections are reorganized to optimize the performance of specific functions in adults. This reorganization of connections is achieved through a remarkably conserved phase of developmental circuit ...
Delayed Blastocyst Formation Reduces the Quality and Hatching Ability of Porcine Parthenogenetic Blastocysts by Increasing DNA Damage, Decreasing Cell Proliferation, and Altering Transcription Factor Expression Patterns [0.03%]
延迟囊胚形成通过增加DNA损伤、减少细胞增殖和改变转录因子表达模式来降低猪孤雌生殖囊胚质量和孵化能力
Ling Sun,Yan Wang,Mo Yang et al.
Ling Sun et al.
The purpose of this study was to investigate the influence of blastocyst formation timing on the quality of porcine embryos derived from parthenogenetic activation. Newly formed blastocysts at days 6, 7, and 8 of culture [termed formation 6...
Aaron N Johnson
Aaron N Johnson
Myofibers are highly specialized contractile cells of skeletal muscles, and dysregulation of myofiber morphogenesis is emerging as a contributing cause of myopathies and structural birth defects. Myotubes are the myofiber precursors and und...
Roles of the NR2F Family in the Development, Disease, and Cancer of the Lung [0.03%]
NR2F家族在肺发育、疾病和癌症中的作用
Jiaxin Yang,Wenjing Sun,Guizhong Cui
Jiaxin Yang
The NR2F family, including NR2F1, NR2F2, and NR2F6, belongs to the nuclear receptor superfamily. NR2F family members function as transcription factors and play essential roles in the development of multiple organs or tissues in mammals, inc...