Arya Zandvakili,Brian Gebelein
Arya Zandvakili
Metazoans encode clusters of paralogous Hox genes that are critical for proper development of the body plan. However, there are a number of unresolved issues regarding how paralogous Hox factors achieve specificity to control distinct cell ...
Simon A Ramsbottom,Mary E Pownall
Simon A Ramsbottom
The hedgehog (Hh) signalling pathway is conserved throughout metazoans and plays an important regulatory role in both embryonic development and adult homeostasis. Many levels of regulation exist that control the release, reception, and inte...
Anke M Smits,Paul R Riley
Anke M Smits
In the last decade, cell replacement therapy has emerged as a potential approach to treat patients suffering from myocardial infarction (MI). The transplantation or local stimulation of progenitor cells with the ability to form new cardiac ...
Alessandro Barbarulo,Ching-In Lau,Konstantinos Mengrelis et al.
Alessandro Barbarulo et al.
T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cel...
Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration [0.03%]
软骨细胞在软骨形成、骨关节炎进展和软骨再生中的作用
Hemanth Akkiraju,Anja Nohe
Hemanth Akkiraju
Articular cartilage (AC) covers the diarthrodial joints and is responsible for the mechanical distribution of loads across the joints. The majority of its structure and function is controlled by chondrocytes that regulate Extracellular Matr...
Nutrient-Deprived Retinal Progenitors Proliferate in Response to Hypoxia: Interaction of the HIF-1 and mTOR Pathway [0.03%]
营养缺乏的视网膜前体细胞在缺氧情况下的增殖：HIF-1和mTOR途径间的交互作用
Helena Khaliullina,Nicola K Love,William A Harris
Helena Khaliullina
At a cellular level, nutrients are sensed by the mechanistic Target of Rapamycin (mTOR). The response of cells to hypoxia is regulated via action of the oxygen sensor Hypoxia-Inducible Factor 1 (HIF-1). During development, injury and diseas...
Notochord Cells in Intervertebral Disc Development and Degeneration [0.03%]
软骨终板和椎间盘基质细胞的分化与退变中的脊柱诺特定居点项目
Matthew R McCann,Cheryle A Séguin
Matthew R McCann
The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back ...
Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease [0.03%]
色素上皮衍生因子(PEDF)是决定干细胞命运的关键因素——一个极罕见疾病的启示
Usman Sagheer,Jingjing Gong,Chuhan Chung
Usman Sagheer
PEDF is a secreted glycoprotein that is widely expressed by multiple organs. Numerous functional contributions have been attributed to PEDF with antiangiogenic, antitumor, anti-inflammatory, and neurotrophic properties among the most promin...
Strain-Dependent Gene Expression during Mouse Embryonic Palate Development [0.03%]
小鼠胚胎腭发育过程中的应变依赖性基因表达
Jiu-Zhen Jin,Jixiang Ding
Jiu-Zhen Jin
The effect of strain background on gene function in growth and development has been well documented. However, it has not been extensively reported whether the strain background affects the gene expression pattern. Here, we found that the ex...
Kayla Gross,Ania Wronski,Adam Skibinski et al.
Kayla Gross et al.
During the formation of breast cancer, many genes become altered as cells evolve progressively from normal to a pre-malignant to a malignant state of growth. How mutations in genes lead to specific subtypes of human breast cancer is only pa...