Rui Caetano Oliveira,Sandra Ferreira,Isabel Gonçalves et al.
Rui Caetano Oliveira et al.
Despite looking monotonous, liver histology represents a highly complex structure of hepatocytes, bile ducts and vessels. This complex interaction and development originate in embryology and remain in adult life. In this manuscript, we high...
Andrew S Powers,Petar Gajic,Ethan Rittereiser et al.
Andrew S Powers et al.
We examined whether an increase in synaptic activity resulted in an increase in quantal size at the neuromuscular junction (NMJ) of third-instar Drosophila larvae. Spontaneous miniature excitatory postsynaptic currents (mEPSCs) or miniature...
Exploring the Regulation of Tmem182 Gene Expression in the Context of Retinoid X Receptor Signaling [0.03%]
视黄醇X受体信号背景下TMEM182基因表达调控的探究
Saadia Khilji,Munerah Hamed,Jihong Chen et al.
Saadia Khilji et al.
We have previously established that bexarotene, a clinically approved agonist of retinoid X receptor (RXR), promotes the differentiation and fusion of skeletal myoblasts. We have also analyzed the genomic programs underlying rexinoid-enhanc...
High Concentrations of Non-Esterified Fatty Acids During Bovine In Vitro Fertilisation Are Detrimental for Spermatozoa Quality and Pre-Implantation Embryo Development [0.03%]
体外受精过程中较高的非酯化脂肪酸浓度会对精子质量和胚胎发育产生不利影响
Abdullah F Idriss,Edward J Okello,Roger G Sturmey et al.
Abdullah F Idriss et al.
High non-esterified fatty acids (NEFAs) during negative energy balance in dairy cattle can impair reproduction. While their effects on oocyte maturation and preimplantation embryo development are known, their impact during fertilisation is ...
An Integrated Canonical and Non-Canonical Wnt Signaling Network Controls Early Anterior-Posterior Axis Formation in Sea Urchin Embryos [0.03%]
海胆胚胎早期前后轴形成的整合经典和非经典Wnt信号网络
Jennifer L Fenner,Boyuan Wang,Cheikhouna Ka et al.
Jennifer L Fenner et al.
Wnt signaling is an ancient developmental mechanism that drives the initial specification and patterning of the primary axis in many metazoan embryos. Yet, it is unclear how exactly the various Wnt components interact in most Wnt-mediated d...
A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes [0.03%]
2-羟基雌二醇以超生理剂量施用损害小鼠窦卵泡的减数分裂进程和发育能力
Valeria Merico,Paola Rebuzzini,Mario Zanoni et al.
Valeria Merico et al.
Estrogen metabolites (EMs) play a local regulatory role in mammalian ovarian function. Among them, 2-hydroxyestradiol (2-OHE2) exerts dose-dependent effects on reproductive physiology, supporting either normal ovarian processes or contribut...
Signaling Pathways in Human Blastocyst Development: From Molecular Mechanisms to In Vitro Optimization [0.03%]
人类囊胚发育中的信号通路：从分子机制到体外优化
Yan Jiao,Jiapeng Liu,Congge Li et al.
Yan Jiao et al.
In recent years, assisted reproductive technology (ART) has developed rapidly with the delay in reproductive age and the rise in infertility rates. During ART, blastocyst quality is a key factor affecting the rate of implantation and clinic...
Zebrafish Unga Is Required for Genomic Maintenance upon Genotoxic Stress and Male Fertility [0.03%]
斑马鱼Unga在耐受基因毒性应激和雄性生育中维持基因组稳定性的功能研究
Latifa Kazzazy,Flóra Huba,Bálint Lóránt Hausz et al.
Latifa Kazzazy et al.
DNA repair is a multifaceted biological process that involves multiple pathways to counter the types of damage the genome encounters throughout life. In the past decade zebrafish became a popular model organism to study various aspects of v...
Profilin and Non-Canonical Wnt Signaling: Coordinating Cytoskeletal Dynamics from Development to Disease [0.03%]
profilin和非canonical wnt信号通路：从发育到疾病期间的细胞骨架动力学协调者
Samira Alam,Danielle Duncan,Sharmin Hasan
Samira Alam
Vertebrate embryonic development relies on tightly regulated signaling pathways that guide morphogenesis, cell fate specification, and tissue organization. Among these, the Wnt signaling pathway plays a central role, orchestrating key devel...
Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex [0.03%]
ドロソフォラCOMPASS複合体のサブユニットSet1とAsh2は卵母細胞決定および接合小体複合体維持に必要である
Brigite Cabrita,Mary Enyioko,Rui Gonçalo Martinho
Brigite Cabrita
Female gametogenesis is orchestrated by dynamic epigenetic modifications. In mammals, SETDB1, a histone H3K9 methyltransferase, is required for proper meiotic progression and early embryonic development. In Drosophila, the ortholog of SETDB...