Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development [0.03%]
RNA新生：果蝇揭示了早期发育中转录组动态的新型见解
Fabio Alexis Lefebvre,Éric Lécuyer
Fabio Alexis Lefebvre
Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new o...
Dynamic Tissue Rearrangements during Vertebrate Eye Morphogenesis: Insights from Fish Models [0.03%]
脊椎动物眼形态发生的组织动态重排：来自鱼类模型的见解
Florencia Cavodeassi
Florencia Cavodeassi
Over the last thirty years, fish models, such as the zebrafish and medaka, have become essential to pursue developmental studies and model human disease. Community efforts have led to the generation of wide collections of mutants, a complet...
Taking the Occam's Razor Approach to Hedgehog Lipidation and Its Role in Development [0.03%]
用奥卡姆剃刀法研究豪猪脂化及其在发育中的作用
Dominique Manikowski,Philipp Kastl,Kay Grobe
Dominique Manikowski
All Hedgehog (Hh) proteins signal from producing cells to distant receiving cells despite being synthesized as N-and C-terminally lipidated, membrane-tethered molecules. To explain this paradoxical situation, over the past 15 years, several...
The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer [0.03%]
果蝇发育、免疫和癌症中的SUMO靶向泛素酶的生物学研究
Mona Abed,Eliya Bitman-Lotan,Amir Orian
Mona Abed
The ubiquitin and SUMO (small ubiquitin-like modifier) pathways modify proteins that in turn regulate diverse cellular processes, embryonic development, and adult tissue physiology. These pathways were originally discovered biochemically in...
Modeling Alzheimer's and Other Age Related Human Diseases in Embryonic Systems [0.03%]
用胚胎系统模拟阿尔茨海默病及其他老年期人类疾病
Chu Hsien Lim,Ajay S Mathuru
Chu Hsien Lim
Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used i...
Contributions of Noncanonical Smoothened Signaling During Embryonic Development [0.03%]
非经典的Smoothened信号通路在胚胎发育中的作用
Tanushree Pandit,Stacey K Ogden
Tanushree Pandit
The Sonic Hedgehog (Shh) signaling pathway is active during embryonic development in metazoans, and provides instructional cues necessary for proper tissue patterning. The pathway signal transducing component, Smoothened (Smo), is a G prote...
Margery G Smelkinson
Margery G Smelkinson
The Hedgehog (Hh) signaling pathway plays an essential role in the growth, development, and homeostatis of many tissues in vertebrates and invertebrates. Much of what is known about Hh signaling is in the context of embryonic development an...
The α-Tubulin gene TUBA1A in Brain Development: A Key Ingredient in the Neuronal Isotype Blend [0.03%]
α-微管蛋白基因TUBA1A与脑发育：神经元同种型混合的关键成分
Jayne Aiken,Georgia Buscaglia,Emily A Bates et al.
Jayne Aiken et al.
Microtubules are dynamic cytoskeletal polymers that mediate numerous, essential functions such as axon and dendrite growth and neuron migration throughout brain development. In recent years, sequencing has revealed dominant mutations that d...
Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors [0.03%]
抑制子缺失导致中间祖细胞的增殖
Odessa R Yabut,Hui Xuan Ng,Gloria Fernandez et al.
Odessa R Yabut et al.
Neural progenitors in the embryonic neocortex must be tightly regulated in order to generate the correct number and projection neuron subtypes necessary for the formation of functional neocortical circuits. In this study, we show that the i...
Transcriptional Control of Cell Lineage Development in Epicardium-Derived Cells [0.03%]
心表细胞系祖细胞分化过程中的转录控制机制研究进展
Caitlin M Braitsch,Katherine E Yutzey
Caitlin M Braitsch
Epicardial derivatives, including vascular smooth muscle cells and cardiac fibroblasts, are crucial for proper development of the coronary vasculature and cardiac fibrous matrix, both of which support myocardial integrity and function in th...