A Kinase Duet Performance in the Asymmetric Division of Drosophila Neuroblasts [0.03%]
果蝇神经干细胞不对称分裂中的激酶二人转表演
Christopher A Johnston
Christopher A Johnston
The ability of progenitor stem cells to divide asymmetrically allows for the production of diverse daughter cell fates.[...]. K...
Maisa Seppala,Gareth J Fraser,Anahid A Birjandi et al.
Maisa Seppala et al.
Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates. Signal transduction is involved in early specificati...
Vincenzo Zappavigna
Vincenzo Zappavigna
This Special Issue of Journal of Developmental Biology (JDB) covers an indeed very "special" (at least to me) family of highly evolutionarily conserved genes, the Hox genes.[...].
Moving the Shh Source over Time: What Impact on Neural Cell Diversification in the Developing Spinal Cord? [0.03%]
随时间变化的Shh信号源对发育中脊髓神经元细胞多样化的的影响？
Cathy Danesin,Cathy Soula
Cathy Danesin
A substantial amount of data has highlighted the crucial influence of Shh signalling on the generation of diverse classes of neurons and glial cells throughout the developing central nervous system. A critical step leading to this diversity...
Hugo Fernandes-Silva,Jorge Correia-Pinto,Rute Silva Moura
Hugo Fernandes-Silva
The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue pol...
Nikole R Zuñiga,Esther T Stoeckli
Nikole R Zuñiga
As reflected by the term morphogen, molecules such as Shh and Wnts were identified based on their role in early development when they instruct precursor cells to adopt a specific cell fate. Only much later were they implicated in neural cir...
Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila [0.03%]
Dynein-适配蛋白Spindly在果蝇有丝分裂和有丝分裂后功能中的需求性研究
Giuliana D Clemente,Matthew R Hannaford,Hamze Beati et al.
Giuliana D Clemente et al.
Spindly was originally identified as a specific regulator of Dynein activity at the kinetochore. In early prometaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions...
Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective [0.03%]
Wingless/Wnt信号通路在肠道发育、稳态、再生和致瘤过程中的作用：果蝇视角
Ai Tian,Hassina Benchabane,Yashi Ahmed
Ai Tian
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous poly...
Elizabeth C Coffey,Maggie E Pasquarella,Michelle F Goody et al.
Elizabeth C Coffey et al.
Alcoholic myopathies are characterized by neuromusculoskeletal symptoms such as compromised movement and weakness. Although these symptoms have been attributed to neurological damage, EtOH may also target skeletal muscle. EtOH exposure duri...
Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish [0.03%]
晚期幼体斑马鱼 optic tectum 中神经元活性的成像技术
Katharina Bergmann,Paola Meza Santoscoy,Konstantinos Lygdas et al.
Katharina Bergmann et al.
The zebrafish is an established model to study the development and function of visual neuronal circuits in vivo, largely due to their optical accessibility at embryonic and larval stages. In the past decade multiple experimental paradigms h...