Alterations in Synthesis and Repair of DNA during the Development of Loach Misgurnus fossilis [0.03%]
家鲤科鱼类Misgurnus fossilis发育过程中DNA合成与修复的变化
Leonid V Gening,Andrei V Lakhin,Irina V Makarova et al.
Leonid V Gening et al.
Using a modified radiolabeled primer extension method (we named this modification misGvA-"misincorporation of G versus A") we have investigated the DNA synthesis and repair at early and late stages of development of loach Misgurnus fossilis...
Beyond the Mammalian Heart: Fish and Amphibians as a Model for Cardiac Repair and Regeneration [0.03%]
超越哺乳动物心脏：以鱼类和两栖类为心脏修复与再生的模型
Kyle Jewhurst,Kelly A McLaughlin
Kyle Jewhurst
The epidemic of heart disease, the leading cause of death worldwide, is made worse by the fact that the adult mammalian heart is especially poor at repair. Damage to the mammal heart-such as that caused by myocardial infarction-leads to sca...
Ttc21b Is Required in Bergmann Glia for Proper Granule Cell Radial Migration [0.03%]
Ttc21b基因在贝格曼胶质细胞中的功能研究及其与颗粒神经元径向迁移的关系
Ashley M Driver,Christopher Shumrick,Rolf W Stottmann
Ashley M Driver
Proper cerebellar development is dependent on tightly regulated proliferation, migration, and differentiation events. Disruptions in any of these leads to a range of cerebellar phenotypes from ataxia to childhood tumors. Animal models have ...
The Role of Hedgehog Signalling in the Formation of the Ventricular Septum [0.03%]
Hedgehog信号在室间隔形成中的作用
Antonia Wiegering,Ulrich Rüther,Christoph Gerhardt
Antonia Wiegering
An incomplete septation of the ventricles in the vertebrate heart that disturbes the strict separation between the contents of the two ventricles is termed a ventricular septal defect (VSD). Together with bicuspid aortic valves, it is the m...
Dagmara Korona,Stefan A Koestler,Steven Russell
Dagmara Korona
The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes. Tools for introducing tags into genes at their endogenous...
Héctor Herranz,Stephen M Cohen
Héctor Herranz
Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these...
Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control [0.03%]
DYRK激酶在胚胎发生和Hh信号通路调控中的新作用
Rajeev Singh,Matthias Lauth
Rajeev Singh
Hedgehog (Hh)/GLI signaling is an important instructive cue in various processes during embryonic development, such as tissue patterning, stem cell maintenance, and cell differentiation. It also plays crucial roles in the development of man...
Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer [0.03%]
Hedgehog信号通路在表皮及毛囊发育、稳态及肿瘤发生中的作用
Yoshinori Abe,Nobuyuki Tanaka
Yoshinori Abe
The epidermis is the outermost layer of the skin and provides a protective barrier against environmental insults. It is a rapidly-renewing tissue undergoing constant regeneration, maintained by several types of stem cells. The Hedgehog (HH)...
The Roles of the Wnt-Antagonists Axin and Lrp4 during Embryogenesis of the Red Flour Beetle Tribolium castaneum [0.03%]
模式生物赤 flour beetle 中Wnt拮抗蛋白Axin和Lrp4在胚胎发育中的作用研究
Romy Prühs,Anke Beermann,Reinhard Schröder
Romy Prühs
In both vertebrates and invertebrates, the Wnt-signaling pathway is essential for numerous processes in embryogenesis and during adult life. Wnt activity is fine-tuned at various levels by the interplay of a number of Wnt-agonists (Wnt liga...
Nicholas S Tolwinski
Nicholas S Tolwinski
Drosophila melanogaster, known colloquially as the fruit fly, remains one of the most commonly used model organisms for biomedical science.[...]. ...