Asxl2-/- Mice Exhibit De Novo Cardiomyocyte Production during Adulthood [0.03%]
Asxl2基因敲除小鼠在成年期出现新的心肌细胞产生现象
Rachel Brunner,Hsiao-Lei Lai,Zane Deliu et al.
Rachel Brunner et al.
Heart attacks affect more than seven million people worldwide each year. A heart attack, or myocardial infarction, may result in the death of a billion cardiomyocytes within hours. The adult mammalian heart does not have an effective mechan...
An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center [0.03%]
一个进化上保守的网络调控ゾーナ・リミタns・インタラティカ的发展，该区域是分泌 sonic hedgehog 的丘脑前信号中心
Elena Sena,Kerstin Feistel,Béatrice C Durand
Elena Sena
Recent studies revealed new insights into the development of a unique caudal forebrain-signaling center: the zona limitans intrathalamica (zli). The zli is the last brain signaling center to form and the first forebrain compartment to be es...
Wade Bushman
Wade Bushman
The prostate is a developmental model system study of prostate growth regulation. Historically the research focus was on androgen regulation of development and growth and instructive interactions between the mesenchyme and epithelium. The s...
Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage [0.03%]
刺猬信号通路在少突胶质细胞谱系发育中的作用
Elisabeth Traiffort,Mary Zakaria,Yousra Laouarem et al.
Elisabeth Traiffort et al.
The Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago. The pathway is notably implicated in the initial appearance of the progenitors ...
Control of Hedgehog Signalling by the Cilia-Regulated Proteasome [0.03%]
由纤毛调控的蛋白酶体对 hedgehog 信号通路的调节作用
Christoph Gerhardt,Antonia Wiegering,Tristan Leu et al.
Christoph Gerhardt et al.
The Hedgehog signalling pathway is evolutionarily highly conserved and essential for embryonic development of invertebrates and vertebrates. Consequently, impaired Hedgehog signalling results in very severe human diseases, ranging from holo...
Hedgehog Promotes Production of Inhibitory Interneurons in Vivo and in Vitro from Pluripotent Stem Cells [0.03%]
刺猬信号促进多能干细胞体内外向抑制性中间神经元分化
Nickesha C Anderson,Christopher Y Chen,Laura Grabel
Nickesha C Anderson
Loss or damage of cortical inhibitory interneurons characterizes a number of neurological disorders. There is therefore a great deal of interest in learning how to generate these neurons from a pluripotent stem cell source so they can be us...
A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint [0.03%]
别具一格的关节： hedgehog 信号通路在颞下颌关节发育中的作用不容小觑
Malgorzata Kubiak,Mark Ditzel
Malgorzata Kubiak
This review highlights the essential role of Hedgehog (Hh) signalling in the developmental steps of temporomandibular joint (TMJ) formation. We review evidence for intra- and potentially inter-tissue Hh signaling as well as Glioma-Associate...
The Role of Sonic Hedgehog in Craniofacial Patterning, Morphogenesis and Cranial Neural Crest Survival [0.03%]
Sonic Hedgehog在颅面图案、形态发生及颅 crest神经嵴存活中的作用
Sebastian Dworkin,Yeliz Boglev,Harley Owens et al.
Sebastian Dworkin et al.
Craniofacial defects (CFD) are a significant healthcare problem worldwide. Understanding both the morphogenetic movements which underpin normal facial development, as well as the molecular factors which regulate these processes, forms the c...
Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration [0.03%]
转化生长因子β亚型在伤口愈合和组织再生中的信号转导
Richard W D Gilbert,Matthew K Vickaryous,Alicia M Viloria-Petit
Richard W D Gilbert
Transforming growth factor beta (TGFβ) signalling is essential for wound healing, including both non-specific scar formation and tissue-specific regeneration. Specific TGFβ isoforms and downstream mediators of canonical and non-canonical ...
Shinsuke Ohba
Shinsuke Ohba
Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts ...