Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System [0.03%]
果蝇作为发育生物学模型：发育神经系统中的干细胞命运决定机制
Katherine Harding,Kristin White
Katherine Harding
Stem cells face a diversity of choices throughout their lives. At specific times, they may decide to initiate cell division, terminal differentiation, or apoptosis, or they may enter a quiescent non-proliferative state. Neural stem cells in...
Riley Kellermeyer,Leah M Heydman,Grant S Mastick et al.
Riley Kellermeyer et al.
Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal d...
Protein Kinase A Signaling Inhibits Iridophore Differentiation in Zebrafish [0.03%]
蛋白激酶A信号抑制斑马鱼虹彩细胞的分化
Cynthia D Cooper,Steve D Erickson,Scott Yin et al.
Cynthia D Cooper et al.
In zebrafish (Danio rerio), iridophores are specified from neural crest cells and represent a tractable system for examining mechanisms of cell fate and differentiation. Using this system, we have investigated the role of cAMP protein kinas...
Insights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies [0.03%]
发育、遗传和进化研究为探讨哺乳动物神经管闭合缺陷的病因提供新见解
Diana M Juriloff,Muriel J Harris
Diana M Juriloff
The human neural tube defects (NTD), anencephaly, spina bifida and craniorachischisis, originate from a failure of the embryonic neural tube to close. Human NTD are relatively common and both complex and heterogeneous in genetic origin, but...
Drosophila as a Model for Assessing the Function of RNA-Binding Proteins during Neurogenesis and Neurological Disease [0.03%]
利用果蝇作为模型评估RNA结合蛋白在神经发生和神经系统疾病中的功能
Eugenia C Olesnicky,Ethan G Wright
Eugenia C Olesnicky
An outstanding question in developmental neurobiology is how RNA processing events contribute to the regulation of neurogenesis. RNA processing events are increasingly recognized as playing fundamental roles in regulating multiple developme...
A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes [0.03%]
基质金属蛋白酶在非神经源性卵黄囊形成的潜在作用
Paige M Drake,Tamara A Franz-Odendaal
Paige M Drake
The formation of non-neurogenic placodes is critical prior to the development of several epithelial derivatives (e.g., feathers, teeth, etc.) and their development frequently involves morphogenetic proteins (or morphogens). Matrix metallopr...
Heart Development, Coronary Vascularization and Ventricular Maturation in a Giant Danio (Devario malabaricus) [0.03%]
一种大型丹尼鱼（德瓦里奥马巴拉鱼）的心脏发育、冠状血管化和心室成熟化
Olubusola Shifatu,Sarah Glasshagel-Chilson,Hannah M Nelson et al.
Olubusola Shifatu et al.
Giant danios (genus Devario), like zebrafish, are teleosts belonging to the danioninae subfamily of cyprinids. Adult giant danios are used in a variety of investigations aimed at understanding cellular and physiological processes, including...
Development of Normal and Cleft Palate: A Central Role for Connective Tissue Growth Factor (CTGF)/CCN2 [0.03%]
整颌与唇腭裂的发育：基质凝集素II/连接子蛋白2（CTGF/CCN2）的中心作用
Joseph T Tarr,Alex G Lambi,James P Bradley et al.
Joseph T Tarr et al.
Development of the palate is the result of an organized series of events that require exquisite spatial and temporal regulation at the cellular level. There are a myriad of growth factors, receptors and signaling pathways that have been sho...
Mireya Ruiz-Losada,David Blom-Dahl,Sergio Córdoba et al.
Mireya Ruiz-Losada et al.
Appendages are external projections of the body that serve the animal for locomotion, feeding, or environment exploration. The appendages of the fruit fly Drosophilamelanogaster are derived from the imaginal discs, epithelial sac-like struc...
Forced Expression of Foxg1 in the Cortical Hem Leads to the Transformation of Cajal-Retzius Cells into Dentate Granule Neurons [0.03%]
Foxg1诱导Cajal-Retzius细胞发生向齿状颗粒神经元的转分化
Bin Liu,Hongmei Xiao,Chunjie Zhao
Bin Liu
The Wnt- and BMP-rich cortical hem has been demonstrated to be critical for the pattern formation of the telencephalon, and it is particularly important for the induction of the hippocampus. Meanwhile, the cortical hem is one of the sources...