Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia [0.03%]
Ift88和主纤毛缺失条件下Gli1与Gli2的不同活性
Yuan Wang,Huiqing Zeng,Aimin Liu
Yuan Wang
The primary cilia play essential roles in Hh-dependent Gli2 activation and Gli3 proteolytic processing in mammals. However, the roles of the cilia in Gli1 activation remain unresolved due to the loss of Gli1 transcription in cilia mutant em...
The Forgotten Skeletogenic Condensations: A Comparison of Early Skeletal Development Amongst Vertebrates [0.03%]
被遗忘的骨发生凝聚物：无颌类动物早期骨骼发育的比较研究
Jennifer L Giffin,Danielle Gaitor,Tamara A Franz-Odendaal
Jennifer L Giffin
The development of a skeletogenic condensation is perhaps the most critical yet considerably overlooked stage of skeletogenesis. Described in this comprehensive review are the mechanisms that facilitate skeletogenic condensation formation, ...
Crosstalk of Intercellular Signaling Pathways in the Generation of Midbrain Dopaminergic Neurons In Vivo and from Stem Cells [0.03%]
体内及以干细胞为原料的中脑多巴胺能神经元诱导过程中细胞间信号通路的相互作用
Claude Brodski,Sandra Blaess,Juha Partanen et al.
Claude Brodski et al.
Dopamine-synthesizing neurons located in the mammalian ventral midbrain are at the center stage of biomedical research due to their involvement in severe human neuropsychiatric and neurodegenerative disorders, most prominently Parkinson's D...
The Chromatin Remodeler LET-418/Mi2 is Required Cell Non-Autonomously for the Post-Embryonic Development of Caenorhabditis elegans [0.03%]
染色质重塑因子LET-418/Mi2对秀丽隐杆线虫后胚胎发育是细胞非自主必需的
Makhabbat Saudenova,Chantal Wicky
Makhabbat Saudenova
Chromatin condition is crucial for the cells to respond to their environment. In C. elegans, post-embryonic development is accompanied by the exit of progenitor cells from quiescence in response to food. The chromatin protein LET-418/Mi2 is...
It's about Time: Ossification Center Formation in C57BL/6 Mice from E12⁻E16 [0.03%]
头骨骨化中心形成的时间特异性研究-E12至E16阶段C57BL/6小鼠模型
Kevin Flaherty,Joan T Richtsmeier
Kevin Flaherty
The establishment of precise, high-resolution temporal sequences for morphogenetic events in laboratory mice remains a vexing issue in developmental biology. Mouse embryos collected at the same period of gestation, even those from the same ...
The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning [0.03%]
控制线虫 vulval 细胞命运模式的信号网络
Hanna Shin,David J Reiner
Hanna Shin
EGF, emitted by the Anchor Cell, patterns six equipotent C. elegans vulval precursor cells to assume a precise array of three cell fates with high fidelity. A group of core and modulatory signaling cascades forms a signaling network that de...
Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model [0.03%]
自闭症谱系障碍和智力障碍的产前神经病理学：综合斑马鱼模型的妊娠效应
Robert A Kozol
Robert A Kozol
Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental disorders with overlapping diagnostic behaviors and risk factors. These include embryonic exposure to teratogens and mutations in genes that have importa...
G Proteins and GPCRs in C. elegans Development: A Story of Mutual Infidelity [0.03%]
模式线虫C. elegans发育中的G蛋白和GPCR：相互不忠的故事
Daniel Matúš,Simone Prömel
Daniel Matúš
Many vital processes during C. elegans development, especially the establishment and maintenance of cell polarity in embryogenesis, are controlled by complex signaling pathways. G protein-coupled receptors (GPCRs), such as the four Frizzled...
Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice [0.03%]
斑马鱼和小鼠中Kat2a和Kat2b乙酰基转移酶活性调控颅面软骨和骨骼分化
Rwik Sen,Sofia A Pezoa,Lomeli Carpio Shull et al.
Rwik Sen et al.
Cranial neural crest cells undergo cellular growth, patterning, and differentiation within the branchial arches to form cartilage and bone, resulting in a precise pattern of skeletal elements forming the craniofacial skeleton. However, it i...
Alla Yalonetskaya,Albert A Mondragon,Johnny Elguero et al.
Alla Yalonetskaya et al.
Cell proliferation and cell death are two opposing, yet complementary fundamental processes in development. Cell proliferation provides new cells, while developmental programmed cell death adjusts cell numbers and refines structures as an o...