Discovery of New Markers for Haemogenic Endothelium and Haematopoietic Progenitors in the Mouse Yolk Sac [0.03%]
小鼠卵黄囊中造血内皮和造血祖细胞新标志的发现
Guillermo Diez-Pinel,Alessandro Muratore,Christiana Ruhrberg et al.
Guillermo Diez-Pinel et al.
Erythro-myeloid progenitors (EMPs) originate from the haemogenic endothelium in the yolk sac via an endothelial-to-haematopoietic transition (EHT) to generate blood and immune cells that support embryo development. Yet, the transitory natur...
The Interplay of One-Carbon Metabolism, Mitochondrial Function, and Developmental Programming in Ruminant Livestock [0.03%]
一碳代谢、线粒体功能和反刍动物畜牧的发育可塑性之间的相互作用
Kazi Sarjana Safain,Kendall C Swanson,Joel S Caton
Kazi Sarjana Safain
Maternal nutrition during gestation profoundly influences fetal growth, organogenesis, and long-term offspring performance through developmental programming. Among the molecular mechanisms responsive to maternal nutrient availability, one-c...
A Zebrafish Seizure Model of cblX Syndrome Reveals a Dose-Dependent Response to mTor Inhibition [0.03%]
一种关于cblX综合症的斑马鱼癫痫模型揭示了mTOR抑制的剂量效应关系
Claudia B Gil,David Paz,Briana E Pinales et al.
Claudia B Gil et al.
Mutations in the transcriptional co-factor HCFC1 cause methylmalonic aciduria and homocystinemia, cblX type (cblX) (MIM#309541), non-syndromic X-linked intellectual disability (XLID), and focal epilepsy. Zebrafish studies have revealed incr...
The Epithelial Egg Tooth of the Chicken Shares Protein Markers with the Embryonic Subperiderm and Feathers [0.03%]
鸡的上皮卵齿与胚胎次表皮和羽毛共享蛋白质标志物
Attila Placido Sachslehner,Julia Steinbinder,Claudia Hess et al.
Attila Placido Sachslehner et al.
The epithelial egg tooth is used by birds to open the eggshell for hatching. This ectodermal structure consists of a multilayered periderm and a hard cornified portion, the caruncle or actual egg tooth. Here, we determined the protein compo...
Lana Shteynman,Genevieve Monanian,Gilberto Torres et al.
Lana Shteynman et al.
Placenta Accreta Spectrum (PAS) disorders, including placenta accreta, increta, and percreta, are serious obstetric conditions characterized by abnormal placental adherence to the uterine wall. With increasing incidence, PAS poses significa...
Cardiac Aftermath of Gestational Diabetes-From Intrauterine Impact to Lifelong Complications: A Systematic Review [0.03%]
妊娠糖尿病的心脏后遗症——从宫内影响到终生并发症：系统性综述
Sophia Tsokkou,Ioannis Konstantinidis,Antonios Keramas et al.
Sophia Tsokkou et al.
Background. Gestational diabetes mellitus (GDM) induces maternal hyperglycemia, which may alter fetal cardiac structure and function, increasing short- and long-term cardiovascular risks. Purpose. To systematically review the evidence on th...
How Cytoskeletal Disorders Contribute to Errors in the Chromosomal Segregation of Oocytes and Cleavage Stage Embryos [0.03%]
细胞骨架异常导致卵母细胞和分裂期胚胎染色体分离错误的机制研究进展
Stefka Delimitreva,Irina Chakarova
Stefka Delimitreva
Observations of the processes of oogenesis, fertilization, and the earliest embryonic development have given us the opportunity to estimate the importance of chromosomal distribution errors for the success of mammalian reproduction. It is n...
Dong Zhang,Xiaoyun Pang,Zhenxing Yan et al.
Dong Zhang et al.
Autophagy has a potential regulatory effect on spermatogenesis and testicular development. Dynamic alterations in the testicular autophagy of prepubertal mice were analyzed, and the relationship between autophagy levels and testicular devel...
Cloned Pig Fetuses Have a High Placental Lysophosphatidylcholine Level That Inhibits Trophoblast Cell Activity [0.03%]
克隆猪胎盘卵磷脂-丝氨酸水平高而抑制滋养层细胞活动
Junkun Lai,Xiaoyu Gao,Guke Zhang et al.
Junkun Lai et al.
Somatic cell nuclear transfer (SCNT) or cloning technology is widely used in agriculture and biomedicine. However, the application of this technology is limited by the low developmental competence of cloned embryos or fetuses, which frequen...
Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental Disorders [0.03%]
神经发育障碍中神经干细胞和前体细胞的增殖缺陷
Aki Shigenaka,Eri Nitta,Tadashi Nakagawa et al.
Aki Shigenaka et al.
Neurodevelopmental disorders (NDDs), including autism spectrum disorder, intellectual disability, and attention deficit hyperactivity disorder, are increasingly recognized as disorders of early brain construction arising from defects in neu...