The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish [0.03%]
肿瘤抑制因子腺瘤性结肠息肉病(APC)依赖神经 crest的颅面发育在斑马鱼中的作用是必要的
Xiaolei Liu,William D Jones,Mathieu Quesnel-Vallières et al.
Xiaolei Liu et al.
Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the entire body axis. Roberto Mayor and colleagues have made major contributions to our un...
Regionalized Protein Localization Domains in the Zebrafish Hair Cell Kinocilium [0.03%]
斑马鱼毛细胞kinocilium的区域化蛋白定位域
Timothy Erickson,William Paul Biggers rd,Kevin Williams et al.
Timothy Erickson et al.
Sensory hair cells are the receptors for auditory, vestibular, and lateral line sensory organs in vertebrates. These cells are distinguished by "hair"-like projections from their apical surface collectively known as the hair bundle. Along w...
Ali Zeeshan Fakhar,Jinbao Liu,Karolina M Pajerowska-Mukhtar et al.
Ali Zeeshan Fakhar et al.
Orphan Genes (OGs) are a mysterious class of genes that have recently gained significant attention. Despite lacking a clear evolutionary history, they are found in nearly all living organisms, from bacteria to humans, and they play importan...
An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease [0.03%]
用于探究全基因组复制在发育、进化和疾病中作用的新兴动物模型
Mara Schvarzstein,Fatema Alam,Muhammad Toure et al.
Mara Schvarzstein et al.
Whole genome duplication (WGD) or polyploidization can occur at the cellular, tissue, and organismal levels. At the cellular level, tetraploidization has been proposed as a driver of aneuploidy and genome instability and correlates strongly...
Danielle Dhouailly
Danielle Dhouailly
All living jawed vertebrates possess teeth or did so ancestrally. Integumental surface also includes the cornea. Conversely, no other anatomical feature differentiates the clades so readily as skin appendages do, multicellular glands in amp...
Jak2 and Jaw Muscles Are Required for Buccopharyngeal Membrane Perforation during Mouth Development [0.03%]
jak2和下颌肌肉在口咽膜穿孔过程中的作用关系及其对口腔发育的影响
Amanda J G Dickinson
Amanda J G Dickinson
The mouth is a central feature of our face, without which we could not eat, breathe, or communicate. A critical and early event in mouth formation is the creation of a "hole" which connects the digestive system and the external environment....
Transcription of HOX Genes Is Significantly Increased during Neuronal Differentiation of iPSCs Derived from Patients with Parkinson's Disease [0.03%]
帕金森病患者衍生的诱导多能干细胞向神经元分化过程中HOX基因转录显著增加
Viya B Fedoseyeva,Ekaterina V Novosadova,Valentina V Nenasheva et al.
Viya B Fedoseyeva et al.
Parkinson's disease (PD) is the most serious movement disorder, but the actual cause of this disease is still unknown. Induced pluripotent stem cell-derived neural cultures from PD patients carry the potential for experimental modeling of u...
Osteoderm Development during the Regeneration Process in Eurylepis taeniolata Blyth, 1854 (Scincidae, Sauria, Squamata) [0.03%]
欧罗勒皮斯蛇（Eurylepis taeniolata）再生过程中的骨板发育
Gennady O Cherepanov,Dmitry A Gordeev,Daniel A Melnikov et al.
Gennady O Cherepanov et al.
Osteoderms are bony structures that develop within the dermal layer of the skin in vertebrates and are very often found in different lizard families. Lizard osteoderms are diverse in topography, morphology, and microstructure. Of particular...
Brigite Cabrita,Rui Gonçalo Martinho
Brigite Cabrita
Primary oocyte determination occurs in many organisms within a germ line cyst, a multicellular structure composed of interconnected germ cells. However, the structure of the cyst is itself highly diverse, which raises intriguing questions a...
Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson's Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2 [0.03%]
通过RNA编辑酶ADR-2调控帕金森病模型秀丽隐杆线虫中黄嘌呤脱氢酶(XDH-1)的表达以减轻多巴胺能神经元退行性变
Lindsey A Starr,Luke E McKay,Kylie N Peter et al.
Lindsey A Starr et al.
Differential RNA editing by adenosine deaminases that act on RNA (ADARs) has been implicated in several neurological disorders, including Parkinson's disease (PD). Here, we report results of a RNAi screen of genes differentially regulated i...