Puja Sandhbor,Geofrey John,Sakshi Bhat et al. Puja Sandhbor et al.

Although with aggressive standards of care like surgical resection, chemotherapy, and radiation, high-grade gliomas (HGGs) and brain metastases (BM) treatment has remained challenging for more than two decades. However, technological advanc...

Weiran Cao,Xue Zhang,Jiaxuan Chen et al. Weiran Cao et al.

Mitochondria provides adenosine triphosphate for multiple vital movements to ensure tumor cell proliferation. Compared to the broadly used method of inducing DNA replication arrest to kill cancer, inducing mitochondria damage to cause energ...

Hua Xie,Dongdong Liu,Jintao Shen et al. Hua Xie et al.

Infections of Helicobacter pylori (H. pylori) affect 42.1 % of the Chinese population and 43.1 % of the world population. H. pylori inhabits the mucous sublayer at the pylorus, leading to gastric ulcers, gastritis, and even cancer. Oral ant...

Ting Yang,Zihan Liu,Zixuan Fu et al. Ting Yang et al.

Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer (TNBC) therapy. However, the ferroptos...

Chen Su,Jianhan Lin,Cong Li et al. Chen Su et al.

Nitric oxide (NO) modulates several cancer-related physiological processes and has advanced the development of green methods for cancer treatment and integrated platforms for combination or synergistic therapies. Although a nanoengineering ...

Fenfen Li,Ruyan Yuan,Jiamin Zhang et al. Fenfen Li et al.

Metabolic dysfunction-associated steatotic liver disease (MASLD) has a high global incidence and associated with increased lipid accumulation in hepatocytes, elevated hepatic enzyme levels, liver fibrosis, and hepatic carcinoma. Despite dec...

Xiaoyu Chang,Hui Guo,Yunqian Li et al. Xiaoyu Chang et al.

Glioblastoma (GBM) is a highly infiltrative brain tumor. The treatment of GBM is challenging due to the existence of blood brain barrier, its highly invasive nature, and its heterogeneity. Given the limitations of conventional therapies, th...

Yuan Ding,Ruohan Chen,Jianfen Zhou et al. Yuan Ding et al.

There remain several intractable challenges for chemotherapy in glioma treatment, including the blood-brain barrier (BBB), blood-brain tumor barrier (BBTB), and tumor heterogeneity caused by cancer stem cells (CSCs), which are resistant to ...

Jie Chen,Bing Wang,Lan Shen et al. Jie Chen et al.

Gastrointestinal tract toxicity represents a serious adverse effect of chemotherapy, leading to reduced quality of life and survival. For instance, irinotecan (CPT-11) usually causes severe gastrointestinal toxicity, with a lack of effectiv...

Anitha Sriram,Harshada Ithape,Pankaj Kumar Singh Anitha Sriram

Arthritis is an inflammatory joint disorder that progressively impairs function and diminishes quality of life. Conventional therapies often prove ineffective, as oral administration lacks specificity, resulting in off-target side effects l...