Integrative analysis reveals the role of SUMOylation-related patterns in shaping the tumor microenvironment and predicting treatment sensitivity of colorectal cancer [0.03%]
整合分析揭示SUMO化相关模式在塑造结直肠癌肿瘤微环境和预测治疗敏感性中的作用
Gaojian Cao,Sen Zhang,Hao Zhong et al.
Gaojian Cao et al.
Background: SUMOylation is a critical post-translational modification that governs protein stability, subcellular localization, and signal transduction. Accumulating evidence suggests that dysregulated SUMOylation contrib...
Association of CAB39L gene methylation in peripheral blood leukocytes with the risk, chemotherapy efficacy and prognosis of gastric cancer and construction of risk prediction model [0.03%]
CAB39L基因甲基化与胃癌发病风险、化疗疗效及预后的相关性分析和风险预测模型的建立
Yuqi Liu,Zhan Li,Yaping Feng et al.
Yuqi Liu et al.
Background: Gastric cancer (GC) is a highly prevalent malignant tumor of the digestive tract worldwide, and there is an urgent need to explore non-invasive molecular markers for supporting precise clinical diagnosis and t...
Prognostic modeling and validation of middle ear malignancy outcomes on the basis of SEER population data [0.03%]
基于SEER人群数据的中耳癌预后建模和验证
Yi Ren,Li-Ping Peng,Tao Hou et al.
Yi Ren et al.
Background: Malignant neoplasms of the middle ear represent a rare yet aggressive entity, with limited evidence regarding prognostic determinants and therapeutic outcomes. This study aimed to evaluate the association betw...
Impact of prior cancer history on survival in patients with adenocarcinoma of esophagogastric junction: a retrospective cohort study using SEER database [0.03%]
既往癌症史对食管胃交界部腺癌患者生存影响的回顾队列研究：基于SEER数据库的研究
Hongkun Lai,Jianlong Zhou,Jiabin Zheng et al.
Hongkun Lai et al.
Background: The exclusion of patients with prior malignancies from clinical trials remains controversial, yet its prognostic impact on adenocarcinoma of esophagogastric junction (AEG) is poorly characterized. This retrosp...
UV1 plus pembrolizumab in recurrent and metastatic head and neck squamous cell carcinoma: safe, immunogenic, but lacking efficacy [0.03%]
用于复发和转移性头颈部鳞状细胞癌的UV1联合派姆单抗：安全，具有免疫原性，但缺乏疗效
Guillermo Flores,Marisa R Buchakjian,Molly Heft Neal et al.
Guillermo Flores et al.
Thymic epithelial tumors: a narrative review of diagnostic and therapeutic advances [0.03%]
胸腺上皮肿瘤：诊断和治疗进展的叙述性回顾
Minghai Chen,Yunbin Li,Lihang Liao et al.
Minghai Chen et al.
Background and objective: Thymic epithelial tumors (TETs), comprising thymoma and thymic carcinoma, are rare mediastinal neoplasms that pose significant diagnostic and therapeutic challenges due to their complex anatomy a...
The claudin-18.2-CD3 bispecific antibody IBI389 exerts an antitumor effect on malignant tumors with positive claudin-18.2 expression by promoting T-cell infiltration and remodeling the tumor immune microenvironment [0.03%]
Claudin-18.2-CD3双特异性抗体IBI389通过促进T细胞浸润和重塑肿瘤免疫微环境对Claudin-18.2阳性恶性肿瘤具有抗肿瘤作用
Yajie Zhu,Xiaorong Liu,Chenliang Zhang et al.
Yajie Zhu et al.
Background: Gastric cancer is one of the most lethal malignancies in the world, but effective therapeutic options for patients with this disease remain limited. Claudin-18.2 (CLDN18.2) has emerged as a promising therapeut...
Evaluation of triphenyl phosphate's pathogenic potential and molecular mechanisms in glioblastoma: an integrated network toxicology investigation employing multiple machine learning approaches [0.03%]
三苯基磷酸的致病潜力及胶质母细胞瘤中的作用机制：运用多种机器学习方法的综合网络毒理学研究
Ziyu Wang,Kai Cui,Jialin Wang et al.
Ziyu Wang et al.
Background: Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, and its etiology involves both genetic and environmental factors. Triphenyl phosphate (TPHP), an organophosphorus flame retardant wi...
Combinatorial treatment with donafenib and quercetin suppresses lipid metabolism in HepG2 cells by targeting the CREB1/DRP1/SREBP1 axis [0.03%]
دونافени布联合芦丁通过靶向CREB1/DRP1/SREBP1轴抑制HepG2细胞脂质代谢的联合作用
Lei Xiang,Jinjie Shi,Xueqing Huang et al.
Lei Xiang et al.
Background: Donafenib (DON) has been found to be effective in prolonging progression-free survival for advanced hepatocellular carcinoma (HCC), although it remains limited in improving long-term survival outcomes. Quercet...
Investigating the material basis and molecular mechanisms of Oldenlandia diffusa in the treatment of papillary thyroid carcinoma: a network pharmacology and experimental study [0.03%]
Narrowing网络药理学和实验研究宽叶青藤素行甲状腺癌的物质基础及分子机制探究
Chao Ding,Tie-Feng Shi,Xiang-Jun Kong et al.
Chao Ding et al.
Background: Papillary thyroid carcinoma (PTC) is among the most prevalent forms of thyroid cancer. Traditional Chinese medicine (TCM) has been widely employed in the management of PTC, with Oldenlandia diffusa (OD) demons...